Gang Xing Chen

US Patent:

7582298, Sep 1, 2009

Filed:

Jun 1, 2007

Appl. No.:

11/809482

Inventors:

Sean Stevens - Mohegan Lake NY, US
Tammy T. Huang - Golden Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Eric Smith - New York NY, US
Kevin J. Pobursky - Beacon NY, US
Nicholas J. Papadopoulos - LaGrangeville NY, US
James P. Fandl - LaGrangeville NY, US
Gang Chen - Yorktown Heights NY, US
Margaret Karow - Camarillo CA, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C07K 16/28
A61K 39/395

US Classification:

4241431, 5303879, 53038822

Abstract:

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a Kof about 500 pM or less and blocks IL-6 activity with an ICof 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

US Patent:

7771997, Aug 10, 2010

Filed:

Jun 4, 2008

Appl. No.:

12/132846

Inventors:

Gang Chen - Yorktown Heights NY, US
Robert Babb - Nauet NY, US
James P. Fandl - LaGrangeville NY, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C12N 5/10

US Classification:

435358, 435 691, 435367

Abstract:

Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

US Patent:

8080248, Dec 20, 2011

Filed:

May 14, 2010

Appl. No.:

12/780006

Inventors:

Allen Radin - New York NY, US
Sean Stevens - San Diego CA, US
Tammy T. Huang - Goldens Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Eric Smith - New York NY, US
Kevin J. Pobursky - Beacon NY, US
Nicholas J. Papadopoulos - LaGrangeville NY, US
James P. Fandl - LaGrangeville NY, US
Gang Chen - Yorktown Heights NY, US
Margaret Karow - Camarillo CA, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

A61K 39/395

US Classification:

4241431, 4241301, 4241411, 4241421, 4241441, 514885

Abstract:

The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.

US Patent:

8166076, Apr 24, 2012

Filed:

Mar 8, 2007

Appl. No.:

11/715512

Inventors:

Gang Chen - Sammamish WA, US
Robert Hildreth - Bellevue WA, US
Darren R. Davis - Woodinville WA, US

Assignee:

Microsoft Corporation - Redmond WA

International Classification:

G06F 17/30

US Classification:

707803

Abstract:

Network-side and client-side systems and techniques for managing metadata items describing digital media content available from a number of digital media content sources are described. Disparate metadata items are collected and transcribed based on a common format. The common format facilitates computerized cataloging, searching, and presentation of relevant metadata and/or digital content via a wide variety of client-side devices. The common format includes: a portion for storing descriptive data derived from the original metadata items; a portion for storing data specific to the digital media content source supplying the original metadata; and a services specifier portion used for accessing specific digital media content. The common format may be used to identify relationships between transcribed items of metadata based on virtually unlimited selection criteria, and to facilitate the creation and presentation to users of data sets of related metadata and/or digital media content.

US Patent:

8192741, Jun 5, 2012

Filed:

Nov 1, 2011

Appl. No.:

13/286261

Inventors:

Allen Radin - New York NY, US
Sean Stevens - San Francisco CA, US
Tammy T. Huang - Goldens Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Eric Smith - New York NY, US
Kevin J. Pobursky - Beacon NY, US
Nicholas J. Papadopoulos - LaGrangeville NY, US
James P. Fandl - LaGrangeville NY, US
Gang Chen - Yorktown Heights NY, US
Margaret Karow - Santa Rosa Valley CA, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

A61K 39/395

US Classification:

4241431, 4241301, 4241411, 4241421, 4241441, 514885

Abstract:

The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.

US Patent:

8226241, Jul 24, 2012

Filed:

May 15, 2009

Appl. No.:

12/466790

Inventors:

Gang Chen - Westfield NJ, US
Roland Ryf - Aberdeen NJ, US

Assignee:

Alcatel Lucent - Paris

International Classification:

G03B 21/00
G03B 21/26
H01S 3/10
H01S 3/091
G03H 1/12
G02F 1/135

US Classification:

353 31, 353 94, 372 23, 372 92, 372 71, 372 72, 372 3806, 359 11, 359 27, 349 25, 349 30

Abstract:

An image projector having one or more broadband lasers designed to reduce the appearance of speckle in the projected image via wavelength diversification. In one embodiment, a broadband laser has an active optical element and a nonlinear optical element, both located inside a laser cavity. The broadband laser generates an output spectrum characterized by a spectral spread of about 10 nm and having a plurality of spectral lines corresponding to different spatial modes of the cavity. Different individual spectral lines effectively produce independent speckle configurations, which become intensity-superimposed in the projected image, thereby causing a corresponding speckle-contrast reduction.

US Patent:

8250635, Aug 21, 2012

Filed:

Jul 13, 2008

Appl. No.:

12/172252

Inventors:

Suresh N. Chari - Scarsdale NY, US
Gang Chen - Syosset NY, US
Todd Eric Kaplinger - Raleigh NC, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 7/04

US Classification:

726 5

Abstract:

A method, system and computer program product for enabling authentication of an OpenID user when a requested identity provider is unavailable. A relying party receives a login request from the OpenID user, where the login request includes a username. The relying party reads a list of trusted identity providers that are associated with the received username and selects one of those identity providers. The relying party generating an OpenID identifier using an identification (e. g. , Uniform Resource Locator) of the selected identity provider and the username. The relying party transmits an authentication request (request to authenticate the OpenID user) to the selected identity provider using the formed OpenID identifier. If the selected identity provider is unavailable, then the relying party selects another identity provider from the list of identity providers that are associated with the received username and repeats the above process.

US Patent:

8389239, Mar 5, 2013

Filed:

Jun 4, 2010

Appl. No.:

12/793898

Inventors:

Gang Chen - Yorktown Heights NY, US
Robert Babb - Nanuet NY, US
James P. Fandl - LaGrangeville NY, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C12P 21/02

US Classification:

435 691, 435353, 435354, 435358, 435366

Abstract:

Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for enhanced and stable expression of genes in eukaryotic cells.

Address:

702 W 23 St, Lumberton, NC 28358

Phone:

9107389853

VIN:

5FNRL38437B030404

Make:

HONDA

Model:

ODYSSEY

Year:

2007