Gang Lin

US Patent:

7977366, Jul 12, 2011

Filed:

Oct 14, 2004

Appl. No.:

10/575683

Inventors:

Hyunsil Han - New York NY, US
Gang Lin - New York NY, US
Carl Nathan - Larchmont NY, US

Assignee:

Cornell Research Foundation, Inc. - Ithaca NY

International Classification:

A61K 31/4709
A61K 31/41
A61P 37/00

US Classification:

514396, 514403, 514468

Abstract:

The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. The present invention also relates to a method of inhibiting respiratory burst in neutrophils without inhibiting degranulation in or bacterial killing by the neutrophils by contacting neutrophils with the compounds described above.

US Patent:

20110118274, May 19, 2011

Filed:

Aug 25, 2008

Appl. No.:

12/674820

Inventors:

Carl Nathan - Larchmont NY, US
Gang Lin - Forest Hills NY, US

Assignee:

CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY

International Classification:

A61K 31/41
A61K 31/422
A61K 31/427
A61K 31/4245
A61K 31/433
A61K 31/4439
A61K 31/501
A61K 31/506
A61K 31/497
C07D 419/04
A61P 35/00
A61P 31/06
A61P 31/00
A61P 31/04
A61P 31/08

US Classification:

51425205, 514360, 514378, 514374, 514365, 514372, 514364, 514361, 514362, 514342, 514256, 51425505, 548122, 514380, 514376, 514377, 514369, 514370

Abstract:

The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.