John R. DeLoach - Bryan TX Robert L. Harris - Bryan TX Mayery Richard T. - Bryan TX Garret M. Ihler - College Station TX
Assignee:
The United States of America as represented by the Secretary of Agriculture - Washington DC
International Classification:
A61M 500
US Classification:
604 53
Abstract:
A process for encapsulating additives in resealed erythrocytes from the blood of certain mammals. The invention provides a method of preparing material in substantial quantities, to be employed as vaccine which, when reinjected into these mammals, provides a systemic protection against bloodsucking insects or other parasites.
Animal Derived Cell With Antigenic Protein Introduced Therein
Yves-Claude Nicolau - College Station TX Garret M. Ihler - College Station TX
Assignee:
Hapgood, C.V. - Oldwick NJ
International Classification:
C12N 506 C07K 1400
US Classification:
435325
Abstract:
This invention comprises animal derived cells, especially erythrocytes, which have been artificially modified (and referred to as engineered erythrocytes or RBCs) so as to incorporate in their plasma membranes an antigen, CD4 protein derived from lymphocytes) which will cause them to selectively seek out and fuse with other cells that are infected with a virus, especially the AIDS virus. These modified cells can be further altered so as to contain in their cytoplasm a cytotoxic agent which, after the cell has fused with a target cell, will result in the pooling of their respective cytoplasms and the death of both cells. Such modified cells can be used as a basis for an in vitro diagnostic assay involving cells derived from the blood of patients suspected of having AIDS.
Apparatus For Encapsulating Additives In Resealed Erythrocytes
John R. DeLoach - Bryan TX Robert L. Harris - Bryan TX Richard T. Mayer - Bryan TX Garret M. Ihler - College Station TX
Assignee:
The United States of America as represented by the Secretary of Agriculture - Washington DC
International Classification:
B01D 3100
US Classification:
210 85
Abstract:
An apparatus for encapsulating additives in resealed erythrocytes using dialysis is disclosed. A specimen holder, provided with vertical rotation means, is immersed in a dialyzing solution. Means are also provided for: agitation, cooling, heating, temperature control and measurement of the dialyzing solution.
Process For Encapsulating Additives In Resealed Erythrocytes For Disseminating Chemicals Via The Circulatory System
John R. DeLoach - Bryan TX Robert L. Harris - Bryan TX Garret M. Ihler - College Station TX Richard T. Mayer - Bryan TX
Assignee:
The United States of America as represented by the Secretary of Agriculture - Washington DC
International Classification:
A61M 500
US Classification:
128 1R
Abstract:
An apparatus and a process for encapsulating additives in resealed erythrocytes from the blood of certain mammals. The invention provides a means of preparing material in substantial quantities, to be employed as vaccine which, when reinjected into these mammals, provides a systemic protection against blood-sucking insects or other parasites.