Garrett W. Lindemann - Benicia CA, US John Lipani - Fountain Hills AZ, US
Assignee:
Mowycal Lending, LLC - Big Horn WY
International Classification:
C12Q 1/68 C07H 21/04 C12M 1/34
US Classification:
4352872, 435 6, 536 231, 536 241
Abstract:
The present invention provides a biochip microarray, with multiple properties for use in identification of gene- and protein-induction or repression by drugs, the evaluation of efficacy and toxicity of any drug of choice, prediction of efficacy and toxicity of newly-discovered drugs, families of drugs or classes of drugs. Experimental information acquired from the biochip is inputted into a Drug-Gene-Protein-Biology (DGPB) database from which experimental data can be mined and analyzed based on the users preferences. A method for predicting the effect of a test composition for the treatment of a disease also is described. An animal model for the disease is selected. A biochip array for evaluating the effect of the test composition for the treatment of the disease is provided. The test composition is tested in the animal model to obtain a first set of biological markers representative of the effect of the test composition in the animal model. The biochip array generates a first set of data representative of the first set of biological markers.
Phosphorylated Glucomannane Polysaccharides Containing 1-6 And 1-2 Linkages Increase Weight Gain In Poultry
Jose Antonio Matji Tuduri - Madrid, ES Antonio Gomez-Pamo - Madrid, ES Jose Lebrero - Madrid, ES Garrett Lindemann - Sheridan WY, US
International Classification:
A61K 31/715 A23K 1/165
US Classification:
424442000, 514054000
Abstract:
Phosphorylated glucomannans may be purified from naturally occurring sources and used as a supplement to poultry feeds for the benefit of poultry production.
Phosphorylated Glucomannan Polysaccharides Containing 1-6 And 1-2 Linkages Increase Weight Gain In Swine
Jose Antonio Matji Tuduri - Madrid, ES Antonio Gomez-Pamo - Madrid, ES Jose Lebrero - Madrid, ES Garrett Lindemann - Sheridan WY, US
International Classification:
A61K 31/715 A23K 1/165
US Classification:
424442000, 514054000
Abstract:
Phosphorylated glucomannans may be purified from naturally occurring sources and used as a supplement to swine feeds for the benefit of swine production.
Products For Receptor Mediated Activation And Maturation Of Monocyte-Derived Dendritic Cells By A Phosphorylated Glucomannane Polysaccharide
Jose Antonio Matji Tuduri - Madrid, ES Antonio F. Guerrero Gomez-Pamo - Madrid, ES Jose Luis Alonso Lebrero - Madrid, ES Garrett Lindemann - Big Horn WY, US Manuel Lopez Cabrera - Madrid, ES Pedro Majano Rodriguez - Madrid, ES Ricardo Moreno Otero - Madrid, ES Diego Serrano Gomez - Madrid, ES Angel Corbi Lopez - Madrid, ES Samuel Martin Vilchez - Madrid, ES
Phosphorylated glucomannan polysaccharide compositions are shown to effectively enhance healthy immune function. Dosage forms including pills, sprays, functional foods and cosmetics may achieve this benefit while being essentially free of storage protein from nongerminated seeds of
Procedure For Subtractive Hybridization And Difference Analysis
Garrett W. Lindemann - Benicia CA Paula A. Schueler - Benicia CA
Assignee:
Roche Diagnostics Corporation - Indianapolis IN
International Classification:
C12P 1934
US Classification:
435 912
Abstract:
Improved methods for obtaining polynucleotides comprising sequences which differ between two populations of DNA or CDNA are provided. Improvements include reduction in the number of amplification cycles, use of a nuclease digestion step prior to amplification, a novel oligonucleotide adapter for the practice of the improved method, and novel methods for selective amplification of the desired unique fragments and selective degradation of fragments containing sequences common to both populations. Fragments of a sample population are amplified using a primer that endows the amplification products with resistance to nuclease degradation. Fragments of a control population are amplified using a primer that targets the amplification products for preferential degradation. Multiple cycles of hybridization, nuclease treatment and amplification are utilized to provide enrichment of fragments unique to the sample population. Such unique fragments may represent new or amplified sequences in the sample population, sequences that are differently arranged in the sample population compared to the control population, and sequences that are differentially expressed in a cDNA population.
Procedure For Subtractive Hybridization And Difference Analysis
Garrett W. Lindemann - Benicia CA Paula A. Schueler - Benicia CA
Assignee:
Roche Diagnostics Corporation - Indianapolis IN
International Classification:
C12P 1934
US Classification:
435 912
Abstract:
Improved methods for obtaining polynucleotides comprising sequences which differ between two populations of DNA or cDNA are provided. Improvements include reduction in the number of amplification cycles, use of a nuclease digestion step prior to amplification, a novel oligonucleotide adapter for the practice of the improved method, and novel methods for selective amplification of the desired unique fragments and selective degradation of fragments containing sequences common to both populations. Fragments of a sample population are amplified using a primer that endows the amplification products with resistance to nuclease degradation. Fragments of a control population are amplified using a primer that targets the amplification products for preferential degradation. Multiple cycles of hybridization, nuclease treatment and amplification are utilized to provide enrichment of fragments unique to the sample population. Such unique fragments may represent new or amplified sequences in the sample population, sequences that are differently arranged in the sample population compared to the control population, and sequences that are differentially expressed in a cDNA population.
System And Methods For Analyzing Biosensor Test Results
A system for analyzing biological specimens by spectral imaging includes a biosensor comprising at least one graphene layer on a substrate and a memory in communication with a processor. The biosensor is configured to acquire a biological specimen sample. The memory and the processor are configured to conduct Raman spectroscopy to obtain spectral data for the sample, transmit the spectral data to a hub for direct or indirect transmission to one or more servers, perform multivariate analysis on the spectral data, and deliver a report based on the multivariate analysis of the spectral data.
Biosensor For Detection Of Sars-Cov-2 Spike Glycoprotein And Related Methods
An example biosensor includes a substrate, a graphene layer disposed on the substrate, and a binding site bonded to the graphene. The binding site includes an antibody configured to bind a SARS-CoV- spike glycoprotein.
Kyield Apr 2015 - Aug 2016
Executive Vice President and Chief Scientific Officer For Life Sciences
Wyoming Ipark Apr 2015 - Aug 2016
Business Development
University of Wyoming Aug 2010 - Apr 2015
Consultant, Start-Ups
Big Stage Coach Productions Jun 2010 - Apr 2015
Partner and Producer
Mowycal Lending Oct 2004 - Apr 2015
Managing Director
Education:
The University of Kansas 1988 - 1994
Doctorates, Doctor of Philosophy, Molecular Biology, Biology, Genetics
Saint John's University 1981 - 1985
Bachelors, Bachelor of Science, Biology, Liberal Arts, Chemistry, History
Big Horn High School 1975 - 1979
St. John's University
Skills:
Molecular Genetics Molecular Biology In Situ Hybridization Fluorescence Microscopy Genetics Start Ups Patents Immunology Immunohistochemistry Immunofluorescence Biotechnology Lifesciences Clinical Trials Medical Devices Clinical Development Pcr Microbiology Technological Innovation Commercialization Microscopy R&D Cell Drug Development Hardware Diagnostics Dependable Team Player Fda Validation Vaccines Cro Genomics Biochemistry Technology Transfer Drug Discovery Bioinformatics Science Infectious Diseases Clinical Research Laboratory Life Sciences Pharmaceutical Industry U.s. Food and Drug Administration Polymerase Chain Reaction Research and Development Cell Biology Patent Law Cro Management
Sep 2004 to 2000 Biotechnology, Device and Pharmaceutical ConsultantFirst documentary is Heart Mountain
Jan 2001 to 2000 Author of many short stories and developer of a novel genre of short storiesHistatek, Inc
Apr 2001 to Sep 2004 Executive Vice President of Research and DevelopmentRoche Diagnostics
Jul 1995 to Jan 2001 Chief Technology Group
Education:
University of Kansas Lawrence, KS 1988 to 1995 Ph.D. in GeneticsUniversity of Minnesota Saint Paul, MN 1985 to 1987 Genetics, Biochemistry and Veterinary MedicineSt. John's University Collegeville, MN 1981 to 1985 B.S. in BiologyBig Horn High School Big Horn, WY 1975 to 1979 Diploma in General
Name / Title
Company / Classification
Phones & Addresses
Garrett Lindemann Managing Part
Genomic Branding, LLC Agriculture Biotechnology Research
PO Box 486, Big Horn, WY 82833 13 Brinton Rd, Big Horn, WY 82833
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Big Horn, WyomingPresident at Lindemann Research Consulting Past: CEO/CSO/Founder at Gourmetceuticals LLC, EVP of Clincial and Pre-Clinical Research and... Self starter with exceptional analytical, quantitative and problem solving skills used to derive and synthesize creative practical solutions to problems of... Self starter with exceptional analytical, quantitative and problem solving skills used to derive and synthesize creative practical solutions to problems of science and business. In conjunction with a quality education, diverse experiences and a drive to overcome hurdles, these skills have been...