Gary L Cook

US Patent:

20050260153, Nov 24, 2005

Filed:

Apr 13, 2005

Appl. No.:

11/104812

Inventors:

Pericles Calias - Melrose MA, US
Gary Cook - Westford MA, US
David Shima - Boston MA, US
David Turner - Norwell MA, US
Mary Ganley - Norwood MA, US

International Classification:

A61K031/785
A61K031/716

US Classification:

424078270, 514054000, 514057000, 514055000

Abstract:

The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.

US Patent:

20050260651, Nov 24, 2005

Filed:

Apr 13, 2005

Appl. No.:

11/105279

Inventors:

Pericles Calias - Melrose MA, US
Gary Cook - Westford MA, US
David Shima - Boston MA, US
Anthony Adamis - Boston MA, US
Yin-Shan Ng - North Billerica MA, US
Gregory Robinson - Wilmington MA, US
David Turner - Norwell MA, US
Mary Ganley - Norwood MA, US

International Classification:

C12Q001/68
C08G063/48

US Classification:

435006000, 525054200

Abstract:

The invention provides compositions and methods for making and using sterically enhanced antagonist aptamer conjugates that include a nucleic acid sequence having a specific affinity for a target molecule and a soluble, high molecular weight steric group that augments or facilitates the inhibition of binding to, or interaction with, the target molecule binding partner by the target molecule when bound to the aptamer conjugate. The present invention also provides methods and formulations for ocular delivery of a biologically active molecule by attaching a charged moiety to the biologically active molecule and delivering the biologically active molecule by iontophoresis. Iontophoresis of a biologically active molecule that is conjugated to a high molecular weight neutral moiety, in enhanced by substituting the high molecular weight neutral moiety with a charged molecule of comparable size.

US Patent:

20110299217, Dec 8, 2011

Filed:

Jun 3, 2011

Appl. No.:

13/152735

Inventors:

Perry J.I. Justesen - Beverly MA, US
Allan D. Weed - Marblehead MA, US
William Davis Lee - Newburyport MA, US
Ashwin M. Purohit - Gloucester MA, US
Robert D. Rathmell - Murphy TX, US
Gary M. Cook - Newton MA, US

Assignee:

Axcelis Technologies, Inc. - Beverly MA

International Classification:

H01L 21/687

US Classification:

361234

Abstract:

An electrostatic clamp is provided, having a clamping plate, wherein a clamping surface of the clamping plate is configured to contact the workpiece. A voltage applied to one or more electrodes selectively electrostatically attracts the workpiece to the clamping surface. One or more auxiliary clamping members are further provided wherein the one or more auxiliary clamping members are configured to selectively secure at least a portion of the workpiece to the clamping surface. A temperature monitoring device configured to determine a temperature of the workpiece is provided, and a controller is configured to selectively clamp the workpiece to the clamping surface via a control of the voltage to the one or more electrodes and the one or more auxiliary clamping members, based, at least in part, on the temperature of the workpiece.

US Patent:

20110299218, Dec 8, 2011

Filed:

Jun 7, 2011

Appl. No.:

13/154836

Inventors:

William Davis Lee - Newburyport MA, US
Gary M. Cook - Newton MA, US
Perry J.I. Justesen - Beverly MA, US
Ashwin M. Purohit - Gloucester MA, US
Robert D. Rathmell - Murphy TX, US
Allan D. Weed - Marblehead MA, US

Assignee:

Axcelis Technologies, Inc. - Beverly MA

International Classification:

H01L 21/687

US Classification:

361234

Abstract:

A clamping device and method is provided for securing first and second workpieces having different sizes to a clamping device and providing thermal conditioning thereto. An electrostatic clamping plate having a diameter associated with the first workpiece surrounds a central portion of the clamp. A non-electrostatic central portion provides a heater within the annulus, wherein the central portion has a diameter associated with the second workpiece. A workpiece carrier is provided, wherein the workpiece carrier is configured to hold the second workpiece above the heater, and wherein a diameter of the workpiece carrier is associated with the electrostatic clamping plate annulus. The annulus selectively electrostatically clamps the workpiece carrier or a circumferential portion of the first workpiece to its clamping surface, therein selectively maintaining a position of the first or second workpiece with respect to the annulus or non-electrostatic central portion.

US Patent:

20200345647, Nov 5, 2020

Filed:

Nov 28, 2018

Appl. No.:

16/767803

Inventors:

- Wiltshire, GB
Gary Paul COOK - Westford MA, US
Jamie Joseph FARRAR - Flintshire, GB
Michael John FRODSHAM - Flintshire, GB
Michael Bryan ROE - Wiltshire, GB
Richard Simon TODD - Wiltshire, GB
Robert Neil WARD - Flintshire, GB

International Classification:

A61K 9/48
C07D 401/14
A61K 9/16
A61K 9/20
A61K 9/28

Abstract:

The present invention relates to oral solid dosage forms comprising a plasma kallikrein inhibitor, in particular a solid form (Form 1) of the compound of Formula A. Also provided are methods of preparing oral solid dosage forms comprising the compound of Formula A using Form 1 of the compound of Formula A.

US Patent:

20160263024, Sep 15, 2016

Filed:

Mar 10, 2016

Appl. No.:

15/066689

Inventors:

- Waltham MA, US
Gary Cook - Westford MA, US
Perry Calias - Melrose MA, US
Michael A. Patane - Waltham MA, US

International Classification:

A61K 9/00
A61N 1/30
A61K 31/573

Abstract:

Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.

US Patent:

20150037429, Feb 5, 2015

Filed:

Sep 18, 2014

Appl. No.:

14/489863

Inventors:

- Bridgewater NJ, US
Pericles Calias - Melrose MA, US
Gary P. Cook - Westford MA, US
Mary A. Ganley - Norwood MA, US

International Classification:

A61K 38/18
A61K 9/00

US Classification:

424501, 514 44 R

Abstract:

Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.