Gary D Cook

US Patent:

7553825, Jun 30, 2009

Filed:

Dec 29, 2004

Appl. No.:

11/026303

Inventors:

Xiaoqin Cheng - Broomfield CO, US
Gary P. Cook - Westford MA, US
Manoj C. Desai - Pleasant Hill CA, US
Edward Doerffler - San Mateo CA, US
Gong-Xin He - Fremont CA, US
Choung U. Kim - San Carlos CA, US
William A. Lee - Los Altos CA, US
John C. Rohloff - Boulder CO, US
Jianying Wang - Foster City CA, US
Zheng-Yu Yang - Foster City CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07F 9/6561
A61K 31/675
A61P 31/20

US Classification:

514 81, 544244

Abstract:

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV,.

US Patent:

8088754, Jan 3, 2012

Filed:

Feb 18, 2009

Appl. No.:

12/388295

Inventors:

Xiaoqin Cheng - Broomfield CO, US
Gary P. Cook - Westford MA, US
Gong-Xin He - Cupertino CA, US
Choung U. Kim - San Carlos CA, US
John C. Rohloff - Boulder CO, US
Jianying Wang - Foster City CA, US
Zheng-Yu Yang - Palo Alto CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07F 9/6561
A61K 31/675
A61P 31/20

US Classification:

514 81, 544244

Abstract:

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV,.

US Patent:

8268802, Sep 18, 2012

Filed:

May 5, 2009

Appl. No.:

12/436004

Inventors:

Xiaoqin Cheng - Broomfield CO, US
Gary P. Cook - Westford MA, US
Manoj C. Desai - Pleasant Hill CA, US
Edward Doerffler - Foster City CA, US
Gong-Xin He - Cupertino CA, US
Choung U. Kim - San Carlos CA, US
William A. Lee - Los Altos CA, US
John C. Rohloff - Boulder CO, US
Jianying Wang - Palo Alto CA, US
Zheng-Yu Yang - Palo Alto CA, US

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07F 9/6561
A61K 31/675
A61P 31/20

US Classification:

514 81, 544244

Abstract:

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV,.

US Patent:

20060030545, Feb 9, 2006

Filed:

Jun 29, 2005

Appl. No.:

11/170247

Inventors:

Xiaoqin Cheng - Broomfield CO, US
Gary Cook - Westford MA, US
Manoj Desai - Pleasant Hill CA, US
Edward Doerffler - Foster City CA, US
Gong-Xin He - Cupertino CA, US
Choung Kim - San Carlos CA, US
William Lee - Los Altos CA, US
John Rohloff - Boulder CO, US
Jianying Wang - Foster City CA, US
Zheng-Yu Yang - Palo Alto CA, US

International Classification:

A61K 31/675
C07F 9/6512

US Classification:

514081000, 544244000

Abstract:

Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Ris —H, —F, —Cl, —Br, —I, —CF, —CN, N, —NO, or —OR; Ris ═O, —O(R), ═S, —N(R), —N(O)(R), —N(OR), —N(O)(OR), or —N(N(R)(R));

US Patent:

20060228414, Oct 12, 2006

Filed:

Jul 15, 2004

Appl. No.:

10/564494

Inventors:

Gary Cook - Longmont CO, US

Assignee:

PR Phamaceuticals, Inc - Fort Collins CO

International Classification:

A61K 48/00
A61K 38/28
A61K 38/09
A61K 38/11
A61K 9/26
A61K 31/70

US Classification:

424469000, 514015000, 514044000, 977906000, 514002000, 514003000, 514009000, 514023000

Abstract:

The methods disclosed herein are of use for the production of controlled release compositions. In particular, the methods provide the contacting of an organic phase containing a bioactive agent and a polymer with an aqueous phase containing an organic ion to create controlled release compositions containing bioactive agents. The present invention also includes controlled release compositions including a polymer, an organic ion and a bioactive agent. The present invention also includes methods of using such controlled release compositions. The usefulness of the present invention is that the methods result in the production of controlled release compositions containing bioactive agent capable of administration in a concentrated low-dose form, having low burst and reduced production of degraded bioactive agent.

US Patent:

20070092574, Apr 26, 2007

Filed:

Jul 15, 2004

Appl. No.:

10/565401

Inventors:

Gary Cook - Longmont CO, US

Assignee:

PR PHARMACEUTICALS, INC. - FORT COLLINS CO

International Classification:

A61K 48/00
A61K 38/22
A61K 38/12
A61K 38/09
A61K 31/715
A61K 9/14

US Classification:

424489000, 514012000, 514009000, 514015000, 514044000, 514054000, 977906000

Abstract:

The compositions disclosed herein are for use as controlled release therapeutics for the treatment of a wide variety of diseases. In particular, the compositions provide water soluble bioactive agents, organic ions and polymers where the bioactive agent is efficiently released over time with minimal degradation products. The resulting controlled release composition is capable of administration in a decreased dose volume due to the high drug content and predominance of non-degraded bioactive agent after release. Additionally, the compositions, of the present invention are capable of long term, sustained releases.

US Patent:

20070292475, Dec 20, 2007

Filed:

Dec 1, 2006

Appl. No.:

11/607382

Inventors:

Kathleen Campbell - Longmont CO, US
Pericles Calias - Melrose MA, US
Gary Cook - Westford MA, US
Mary Ganley - Norwood MA, US

International Classification:

A61K 9/52
A61P 27/02

US Classification:

424428000, 424489000

Abstract:

Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. The microparticles are characterized by low burst levels and efficient drug loading and sustained release.

US Patent:

53076818, May 3, 1994

Filed:

Aug 5, 1992

Appl. No.:

7/926065

Inventors:

Eric B. Phelps - Littleton CO
Gary R. Cook - Highlands Ranch CO
Wayne O. Roszelle - Littleton CO

Assignee:

Marathon Oil Company - Findlay OH

International Classification:

G01L 1904

US Classification:

73708

Abstract:

Disclosed is a system wherein the compensation for temperature effects on a pressure measurement gauge are accomplished by processing the raw pressure measurement signal from the gauge through an equation to produce a thermally compensated measurement. The equation expresses the thermally compensated pressure determination as a relation between a derivative of temperature and temperature. When the gauge is placed in an oil or gas well, the equation is used to obtain a correction for the measured pressure from the temperature measured adjacent to the pressure gauge.