Gary B Gustafson

US Patent:

7307079, Dec 11, 2007

Filed:

May 30, 2003

Appl. No.:

10/448024

Inventors:

Jacobus A.J. Den Hartog - Weesp, NL
Jan H. Reinders - Weesp, NL
Guustaaf J.M. Van Scharrenburg - Weesp, NL
Maria L. Pras-Raves - Weesp, NL
Gary R. Gustafson - Bedford MA, US

Assignee:

Solvay Pharmaceuticals, B.V. - Weesp
Arqule, Inc. - Woburn MA

International Classification:

C07D 251/46
C07D 251/52
C07D 251/54
C07D 401/04
C07D 401/14
C07D 403/04
C07D 403/14
A61K 31/53
A61K 31/4025
A61K 31/4523
A61P 11/06
A61P 17/06
A61P 25/26
A81P 19/02

US Classification:

514245, 514241, 51421705, 544197, 544198, 544207, 544208, 544209, 544219, 540480, 540596

Abstract:

The invention relates to a group of novel triazine derivatives which are ligands for human adenosine-Areceptors, as well as to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient. The invention relates to compounds of the general formula (1).

US Patent:

59861118, Nov 16, 1999

Filed:

Mar 21, 1997

Appl. No.:

8/822323

Inventors:

Mark A. Wuonola - Waltham MA
Gary R. Gustafson - Bedford MA
James S. Panek - Randilph MA
Tau Hu - Boston MA
Jennifer V. Schaus - Boston MA

Assignee:

Scriptgen Pharmaceuticals, Inc. - Waltham MA
Trustees of Boston University - Boston MA

International Classification:

C07C 3303
C07C 4526
C07C 6730
C07D30932

US Classification:

549291

Abstract:

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

US Patent:

62288822, May 8, 2001

Filed:

Sep 15, 1999

Appl. No.:

9/397765

Inventors:

Mark A. Wuonola - Waltham MA
Gary R. Gustafson - Bedford MA
James S. Panek - Randolph MA
Tao Hu - Boston MA
Jennifer V. Schaus - Brookline MA

Assignee:

Anadys Pharmaceuticals, Inc. - Boston MA
Scriptgen Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K 31351
C07D30922

US Classification:

514460

Abstract:

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

US Patent:

59425474, Aug 24, 1999

Filed:

Sep 6, 1996

Appl. No.:

8/709343

Inventors:

Gary R. Gustafson - Bedford MA
David G. Powers - Maynard MA
Mark A. Wuonola - Waltham MA

Assignee:

Scriptgen Pharmaceuticals, Inc. - Waltham MA

International Classification:

A61K 3116
C07C23300

US Classification:

514616

Abstract:

This invention provides a compound having the formula: ##STR1## wherein R. sup. 1 and R. sup. 3 independently are hydrogen, --CHO, --COCH. sub. 3, --COR. sup. 7, --A--Ar--(Q). sub. z, etc. ; wherein D is a C. sub. 1-6 linear, C. sub. 3-8 branched or cyclic group having from 4 to about 15 atoms, consisting of C, etc. ; wherein D is unsubstituted or substituted with one or more groups independently selected from the group consisting of --OH, NH. sub. 2, --NHR. sub. 7, etc. ; wherein each Q is independently --CNH(NHY), --NHCNH(NHY), --SO. sub. 2 W, --SOW, etc. ; wherein Y is hydrogen, alkyl, alkenyl, --B--NH. sub. 2, --B--NHR. sup. 8, etc. ; wherein W is alkyl, alkenyl, --B--NH. sub. 2, etc. ; wherein A nd B independently are a bond, or a C. sub. 1-6 linear, C. sub.

US Patent:

62392913, May 29, 2001

Filed:

May 18, 2000

Appl. No.:

9/574134

Inventors:

Mark A. Wuonola - Waltham MA
Gary R. Gustafson - Bedford MA
James S. Panek - Randolph MA
Tao Hu - Boston MA
Jennifer V. Schaus - Brookline MA

Assignee:

Scriptgen Pharmaceuticals, Inc. - Waltham MA
Trustees of Boston University - Boston MA

International Classification:

C07D30932

US Classification:

549291

Abstract:

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

US Patent:

61275514, Oct 3, 2000

Filed:

Aug 9, 1999

Appl. No.:

9/370535

Inventors:

Mark A. Wuonola - Waltham MA
Gary R. Gustafson - Bedford MA
James S. Panek - Randolph MA
Tao Hu - Boston MA
Jennifer V. Schaus - Boston MA

Assignee:

Scriptgen Pharmaceuticals, Inc. - Waltham MA
Trustees of Boston University - Boston MA

International Classification:

C07D30932

US Classification:

549291

Abstract:

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

US Patent:

60229837, Feb 8, 2000

Filed:

Jan 2, 1998

Appl. No.:

9/002541

Inventors:

Mark A. Wuonola - Waltham MA
Gary R. Gustafson - Bedford MA
James S. Panek - Randolph MA
Tao Hu - Boston MA
Jennifer V. Schaus - Brookline MA

Assignee:

Scriptgen Pharmaceuticals, Inc. - Waltham MA
Trustees of Boston University - Boston MA

International Classification:

C07C 3303
C07C 4526
C07C 6730
C07D30932

US Classification:

549291

Abstract:

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.

US Patent:

60909536, Jul 18, 2000

Filed:

Aug 9, 1999

Appl. No.:

9/370533

Inventors:

Mark A. Wuonola - Waltham MA
Gary R. Gustafson - Bedford MA
James S. Panek - Randolph MA
Tao Hu - Boston MA
Jennifer V. Schaus - Boston MA

Assignee:

Scriptgen Pharmaceuticals, Inc. - Boston MA
Trustees of Boston University - Waltham MA

International Classification:

C07D30932

US Classification:

549291

Abstract:

The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel compositions of matter which are useful for the preparation of pyronin antibiotics.