Gary James Pace

US Patent:

6387409, May 14, 2002

Filed:

Jan 4, 2000

Appl. No.:

09/477351

Inventors:

Sheema Khan - Napean, CA
Gary W. Pace - Durham NC

Assignee:

RTP Pharma Inc. - Durham NC

International Classification:

A61K 914

US Classification:

424489, 424401

Abstract:

Compositions and procedures that yield sub-micron and micron-size stable particles of water-insoluble or poorly soluble drugs or other industrially useful insoluble compounds are prepared using combinations of natural or synthetic phospholipids, a charged surface modifier such as a highly purified charged phospholipid and a block copolymer coated or adhered onto the surfaces of the water insoluble-compound particles. The combination of charged surface modifier and block copolymer allows the formation and stabilization of the sub-micron and micron size compound particlesâstabilized by the charged phospholipid to provide electrostatic stabilization and the block copolymer to provide steric stabilizationâand therefore prevents these particles from particle growth, aggregation or flocculation.

US Patent:

6403865, Jun 11, 2002

Filed:

May 10, 1995

Appl. No.:

08/438666

Inventors:

Michael G. Koziel - Cary NC
Nalini M. Desai - Cary NC
Kelly S. Lewis - Hillsborough NC
Vance C. Kramer - Hillsborough NC
Gregory W. Warren - Cary NC
Stephen V. Evola - Apex NC
Lyle D. Crossland - Chapel Hill NC
Martha S. Wright - Cary NC
Ellis J. Merlin - Raleigh NC
Karen L. Launis - Franklinton NC
Steven J. Rothstein - Guelph, CA
Cindy G. Bowman - Cary NC
John L. Dawson - Chapel Hill NC
Erik M. Dunder - Chapel Hill NC
Gary M. Pace - Cary NC
Janet L. Suttie - Raleigh NC
Nadine Carozzi - Raleigh NC
Annick De Framond - Durham NC
James O. Linder - Owatonna MN
Robert L. Miller - Cedar Rapids IA
Bruce W. Skillings - Innerkip, CA
Alan W. Mousel - Bluffton IN
Albert R. Hornbrook - Bloomington IL
Christopher P. Clucas - Washington Court House OH
Moez Rajabali Meghji - Bloomington IL
Andreas H. Tanner - Plaisance du Touch, FR
Francis E. Cassagne - Auch, FR
Gilles Pollini - LIsle en Dodon, FR
Terry Ray Colbert - Troy TN
Francis P. Cammack - Rochelle IL

Assignee:

Syngenta Investment Corp. - Wilmington DE

International Classification:

A01H 500

US Classification:

800302, 800268, 800265, 8003201, 536 2371

Abstract:

Methods for transformation of maize with nucleic acid sequences of interest are disclosed. The method involves subjecting immature zygotic embryos or Type I callus to high velocity microprojectile bombardment. The method is capable of producing transformed maize lines of commercial importance and their hybrid combinations.

US Patent:

6576264, Jun 10, 2003

Filed:

Mar 12, 1999

Appl. No.:

09/202504

Inventors:

Inge B Henriksen - Durham NC
Awadesh K. Mishra - Durham NC
Gary W. Pace - Durham NC
Keith P. Johnston - Austin TX
Simon Mawson - Austin TX

Assignee:

SkyePharma Canada Inc. - Quebec
Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K 916

US Classification:

424490, 424494, 424496, 424497, 424498, 424489

Abstract:

Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.

US Patent:

6974593, Dec 13, 2005

Filed:

Jun 9, 2003

Appl. No.:

10/458071

Inventors:

Inge B Henriksen - Durham NC, US
Awadesh K. Mishra - Durham NC, US
Gary W. Pace - Durham NC, US
Keith P. Johnston - Austin TX, US
Simon Mawson - Austin TX, US

Assignee:

Jagotec AG - Muttenz
Board of Regents, The University of Texas System - Austin TX

International Classification:

A61K009/16

US Classification:

424490, 424494, 424496, 424497, 424498, 424489

Abstract:

Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.

US Patent:

56251360, Apr 29, 1997

Filed:

Sep 25, 1992

Appl. No.:

7/951715

Inventors:

Michael G. Koziel - Cary NC
Nalini M. Desai - Cary NC
Kelly S. Lewis - Hillsborough NC
Vance C. Kramer - Hillsborough NC
Gregory W. Warren - Cary NC
Stephen V. Evola - Apex NC
Lyle D. Crossland - Chapel Hill NC
Martha S. Wright - Cary NC
Ellis J. Merlin - Raleigh NC
Karen L. Launis - Franklinton NC
Steven J. Rothstein - Guelph, CA
Cindy G. Bowman - Cary NC
John L. Dawson - Chapel Hill NC
Erik M. Dunder - Chapel Hill NC
Gary M. Pace - Cary NC
Janet L. Suttie - Raleigh NC

Assignee:

Ciba-Geigy Corporation - Tarrytown NY

International Classification:

A01H 500
A01H 510
C12N 1532

US Classification:

800205

Abstract:

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

US Patent:

60751851, Jun 13, 2000

Filed:

Jun 2, 1995

Appl. No.:

8/459504

Inventors:

Michael G. Koziel - Cary NC
Nalini M. Desai - Cary NC
Kelly S. Lewis - Hillsborough NC
Gregory W. Warren - Cary NC
Stephen V. Evola - Apex NC
Martha S. Wright - Cary NC
Karen L. Launis - Franklinton NC
Steven J. Rothstein - Guelph, CA
Cindy G. Bowman - Cary NC
John L. Dawson - Chapel Hill NC
Erik M. Dunder - Chapel Hill NC
Gary M. Pace - Cary NC
Janet L. Suttie - Raleigh NC

Assignee:

Novartis Finance Corporation - New York NY

International Classification:

A01H 500
C12N 504
C12N 1582

US Classification:

800302

Abstract:

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

US Patent:

60517603, Apr 18, 2000

Filed:

Jun 2, 1995

Appl. No.:

8/460408

Inventors:

Michael G. Koziel - Cary NC
Nalini M. Desai - Cary NC
Gregory W. Warren - Cary NC
Stephen V. Evola - Apex NC
Martha S. Wright - Cary NC
Karen L. Launis - Franklinton NC
Cindy G. Bowman - Cary NC
John L. Dawson - Chapel Hill NC
Erik M. Dunder - Chapel Hill NC
Gary M. Pace - Cary NC
Janet L. Suttie - Raleigh NC

Assignee:

Novartis Finance Corporation - New York NY

International Classification:

A01H 500
C12N 1582
C12N 1532

US Classification:

800302

Abstract:

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.

US Patent:

63201003, Nov 20, 2001

Filed:

Apr 11, 2000

Appl. No.:

9/547422

Inventors:

Michael G. Koziel - Cary NC
Nalini M. Desai - Cary NC
Kelly S. Lewis - Hillsborough NC
Gregory W. Warren - Cary NC
Stephen V. Evola - Apex NC
Martha S. Wright - Cary NC
Karen L. Launis - Franklinton NC
Steven J. Rothstein - Guelph, CA
Cindy G. Bowman - Cary NC
John L. Dawson - Chapel Hill NC
Erik M. Dunder - Chapel Hill NC
Gary M. Pace - Cary NC
Janet L. Suttie - Raleigh NC

Assignee:

Syngenta Investments, Inc. - Wilmington DE

International Classification:

A01H 500
C12N 1582
C12N 504

US Classification:

800279

Abstract:

DNA sequences optimized for expression in plants are disclosed. The DNA sequences preferably encode for an insecticidal polypeptides, particularly insecticidal proteins from Bacillus thuringiensis. Plant promoters, particular tissue-specific and tissue-preferred promoters are also provided. Additionally disclosed are transformation vectors comprising said DNA sequences. The transformation vectors demonstrate high levels of insecticidal activity when transformed into maize.