Gary D Pearson

US Patent:

7060283, Jun 13, 2006

Filed:

Sep 15, 1993

Appl. No.:

08/392934

Inventors:

Richard S. Smith - Del Mar CA, US
Gary R. Pearson - Great Falls VA, US
D. Elliot Parks - Del Mar CA, US
Susan Pothen Varghese - Centerville VA, US

Assignee:

Ortho Diagnostic Systems, Inc. - Raritan NJ
Georgetown Univeristy - Washington DC

International Classification:

C07K 14/05
C07K 4/02
C07K 14/01

US Classification:

4242301, 530826, 530327, 530324, 530325, 514 2, 4241861, 4242041, 4241921, 4241931, 42419611, 4241991, 435975

Abstract:

Epstein-Barr virus (EBV) specific polypeptides consisting of a series of one to 1000 peptide units selected from the group consisting of peptide units Φ, Γ, Δ and Ω, wherein Φ is 25 amino acids or less and has the formula (αETFTETWNRFITHTEβ) (SEQ ID NO:1), Γ is 25 amino acids or less and has the formula (αGMLEASEGLDGWIHQβ) (SEQ ID NO:2), Δ is 25 amino acids or less and has the formula (αHQQGGWSTLIEDNIβ) (SEQ ID NO:3), Ω is 25 amino acids or less and has the formula (αKQKHPKKVKQAFNPLβ) (SEQ ID NO:4), α and β are each independently from 0 to 5 naturally occurring amino acids, and the polypeptide is capable of binding antibody in a specimen from an individual with Epstein-Barr virus (EBV)-associated disease are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.