Gary R Pearson

US Patent:

7060283, Jun 13, 2006

Filed:

Sep 15, 1993

Appl. No.:

08/392934

Inventors:

Richard S. Smith - Del Mar CA, US
Gary R. Pearson - Great Falls VA, US
D. Elliot Parks - Del Mar CA, US
Susan Pothen Varghese - Centerville VA, US

Assignee:

Ortho Diagnostic Systems, Inc. - Raritan NJ
Georgetown Univeristy - Washington DC

International Classification:

C07K 14/05
C07K 4/02
C07K 14/01

US Classification:

4242301, 530826, 530327, 530324, 530325, 514 2, 4241861, 4242041, 4241921, 4241931, 42419611, 4241991, 435975

Abstract:

Epstein-Barr virus (EBV) specific polypeptides consisting of a series of one to 1000 peptide units selected from the group consisting of peptide units Φ, Γ, Δ and Ω, wherein Φ is 25 amino acids or less and has the formula (αETFTETWNRFITHTEβ) (SEQ ID NO:1), Γ is 25 amino acids or less and has the formula (αGMLEASEGLDGWIHQβ) (SEQ ID NO:2), Δ is 25 amino acids or less and has the formula (αHQQGGWSTLIEDNIβ) (SEQ ID NO:3), Ω is 25 amino acids or less and has the formula (αKQKHPKKVKQAFNPLβ) (SEQ ID NO:4), α and β are each independently from 0 to 5 naturally occurring amino acids, and the polypeptide is capable of binding antibody in a specimen from an individual with Epstein-Barr virus (EBV)-associated disease are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.

US Patent:

7326535, Feb 5, 2008

Filed:

May 21, 2003

Appl. No.:

10/442456

Inventors:

Richard S. Smith - Salt Lake City UT, US
Gary R. Pearson - Sedona AZ, US
D. Elliot Parks - Del Mar CA, US
Susan Pothen Varghese - Melrose MA, US

Assignee:

Ortho Diagnostic Systems Inc. - Raritan NJ
Georgetown University - Washington DC

International Classification:

G01N 33/569
G01N 33/53
G01N 33/543
G01N 33/58

US Classification:

435 71, 435 79, 435 5, 435 792, 436518, 436820, 530324, 530325, 530326, 4241861, 4241931, 4242301

Abstract:

Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.

US Patent:

7988972, Aug 2, 2011

Filed:

Dec 14, 2007

Appl. No.:

11/957251

Inventors:

Richard S. Smith - Salt Lake City UT, US
Gary R. Pearson - Sedona AZ, US
D. Elliot Parks - Del Mar CA, US
Susan Pothen Varghese - Melrose MA, US

Assignee:

Ortho-Clinical Diagnostics, Inc. - Raritan NJ

International Classification:

A61K 39/42
C07K 16/08
C12N 15/06

US Classification:

4241471, 4241421, 4241591, 435339, 435975, 53038815, 5303883

Abstract:

The Epstein-Barr virus (EBV) specific polypeptides ETFTETWNRFITHTE (SEQ. ID NO: 1), GMLEASEGLDGWIHQ (SEQ. ID NO:2), HQQGGWSTLIEDNIP (SEQ. ID NO:3), and KQKHPKKVKQAFNPL (SEQ. ID NO:4) are among those disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment of EBV-associated disease.

US Patent:

56724713, Sep 30, 1997

Filed:

Oct 12, 1995

Appl. No.:

8/542234

Inventors:

Paul John Durda - Needham MA
Elliott Dan Kieff - Brookline MA
Gary Richard Pearson - Great Falls VA
Harvey Rabin - North Andover MA
Marcia Delaney Sullivan - Methuen MA

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C12Q 170
G01N 33563
G01N 33543

US Classification:

435 5

Abstract:

This disclosure concerns an assay for detecting and/or quantifying a mammalian IgA antibody response to EBV-MA with an immobilized EBV-MA gp 350/220 lacking the transmembrane anchor domain.