Gary W Small

US Patent:

54593174, Oct 17, 1995

Filed:

Feb 14, 1994

Appl. No.:

8/195709

Inventors:

Gary W. Small - The Plains OH
Mark Arnold - Iowa City IA

Assignee:

Ohio University - Athens OH
University of Iowa Res. Fdn. - Iowa City IA

International Classification:

G01J 345
G01J 328

US Classification:

2503411

Abstract:

Non-invasive measurements of physiological chemicals such as glucose are made using infrared radiation and a signal processing system that permits the construction of a device suited for home use. The level of a selected physiological chemical in a test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near-infrared radiation such that the radiation is transmitted through or reflected from the test subject; (b) collecting data concerning the transmitted or reflected infrared radiation using a detector; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiological chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The data collected may be in the form of an absorbance spectrum, i. e. , a representation of the variation in absorbance as a function of wavelength; or in the form of an interferogram, i. e.

US Patent:

60615826, May 9, 2000

Filed:

Jun 11, 1997

Appl. No.:

8/860850

Inventors:

Gary W. Small - The Plains OH
Mark Arnold - Iowa City IA

Assignee:

University of Iowa Research Foundation - Iowa City IA
Ohio University - Athens OH

International Classification:

A61B 500

US Classification:

600316

Abstract:

Non-invasive measurements of physiological chemicals such as glucose in a test subject are made using infrared radiation and a signal processing system. The level of a selected physiological chemical in the test subject is determined in a non-invasive and quantitative manner by a method comprising the steps of: (a) irradiating a portion of the test subject with near infrared radiation; (b) collecting data concerning the irradiated light on the test subject; (c) digitally filtering the collected data to isolate a portion of the data indicative of the physiological chemical; and (d) determining the amount of physiolgocial chemical in the test subject by applying a defined mathematical model to the digitally filtered data. The collected data is in the form of either an absorbance spectrum or an interferogram.

US Patent:

20150329892, Nov 19, 2015

Filed:

May 12, 2015

Appl. No.:

14/709685

Inventors:

- Coralville IA, US
Jonathon Todd Olesberg - Iowa City IA, US
Christine Esther Evans - North Liberty IA, US
Mark Allen Arnold - Iowa City IA, US
Gary Wray Small - Coralville IA, US

International Classification:

C12Q 1/02
C12M 1/34
C12M 1/00
G01N 15/14
G01N 21/359

Abstract:

An optical sampling apparatus for miniature-scale bioprocessing vessels includes features for optical interrogation of the bioprocessing vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the bioprocessing vessels during bioprocesses. Multiple such bioprocessing vessels with the optical interrogation features may be mounted in a receiver for conducting multiple bioprocesses simultaneously. A translatable probe may be used to interact with each of the bioprocessing vessels in the receiver.

US Patent:

20150330894, Nov 19, 2015

Filed:

May 12, 2015

Appl. No.:

14/709955

Inventors:

- Coralville IA, US
Jonathon Todd Olesberg - Iowa City IA, US
Christine Esther Evans - North Liberty IA, US
Mark Allen Arnold - Iowa City IA, US
Gary Wray Small - Coralville IA, US

International Classification:

G01N 21/359
B01L 9/00
C12Q 1/02

Abstract:

An optical probe with associated disposable polymer sheath for near-infrared optical interrogation of fluids within bioprocessing vessels by means of transmission or transflection spectroscopy provides for the determination of quantities and parameters of substances in fluids contained within bioprocessing vessels. Associated methods for use of the optical probe and associated sheath to determine quantities of substances in fluids and parameters of fluids during bioprocesses are provided.

US Patent:

20150330903, Nov 19, 2015

Filed:

May 12, 2015

Appl. No.:

14/709932

Inventors:

- Coralville IA, US
Jonathon Todd Olesberg - Iowa City IA, US
Christine Esther Evans - North Liberty IA, US
Mark Allen Arnold - Iowa City IA, US
Gary Wray Small - Coralville IA, US

International Classification:

G01N 21/75
G01N 21/01
G01N 21/17
C12M 1/34
C12M 1/00

Abstract:

An optical sampling apparatus for disposable flexible bioprocessing vessels includes features for optical interrogation of the vessel contents by means of transmission or transflection spectroscopy. This optical interrogation allows for the determination of quantities and parameters of substances in fluids contained within the vessels during bioprocesses.

US Patent:

20150247210, Sep 3, 2015

Filed:

Feb 26, 2015

Appl. No.:

14/631918

Inventors:

Jonathon Todd Olesberg - Iowa City IA, US
Mark Allen Arnold - Iowa City IA, US
Gary Wray Small - Coralville IA, US
Edwin John Koerperick - North Liberty IA, US
Christine Esther Evans - North Liberty IA, US

Assignee:

ASL ANALYTICAL, INC. - Coralville IA

International Classification:

C12Q 3/00
G01N 21/39
G01N 21/359

Abstract:

Methods for continuous, real-time process monitoring and control of bioprocesses by means of near-infrared (NIR) spectroscopy provide analysis of static or flowing fluid streams which may range from clear to highly optically dense. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for wavelength axis calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness for bioprocess monitoring and control.

US Patent:

20150247794, Sep 3, 2015

Filed:

Feb 26, 2015

Appl. No.:

14/631917

Inventors:

- Coralville IA, US
Mark Allen Arnold - Iowa City IA, US
Gary Wray Small - Coralville IA, US
Edwin John Koerperick - North Liberty IA, US
Christine Esther Evans - North Liberty IA, US

Assignee:

ASL ANALYTICAL, INC. - Coralville IA

International Classification:

G01N 21/359
G01N 21/3577

Abstract:

A system and method for continuous, real-time process monitoring and control by means of near-infrared (NIR) spectroscopy provides analysis of static or flowing fluid streams which may range from clear to highly optically dense, including fluids primarily of aqueous composition. A NIR source passes through a wavelength selector to select one or more spectral segments, which are passed through the fluid stream at a fluid sampling interface and received at a sensor. A wavelength reference material is positioned in the optical path for calibration. Quantification of a plurality of characteristics or parameters of a fluid and suspended solids or cells contained therein may be performed. An all-solid-state implementation of the optical system ensures high robustness in laboratory and industrial settings.