Gary P Stack

US Patent:

6407066, Jun 18, 2002

Filed:

Jan 21, 2000

Appl. No.:

09/489164

Inventors:

Darren B. Dressen - San Mateo CA
Anthony Kreft - Langhorne PA
Dennis Kubrak - Philadelphia PA
Charles William Mann - Philadelphia PA
Michael A. Pleiss - Sunnyvale CA
Gary Paul Stack - Ambler PA
Eugene D. Thorsett - Moss Beach CA

Assignee:

Elan Pharmaceuticals, Inc. - South San Francisco CA
American Home Products Corporation - Madison NJ

International Classification:

C07K 506

US Classification:

514 19, 514 18, 530331

Abstract:

Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e. g. , human, such as asthma, Alzheimers disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

US Patent:

6458802, Oct 1, 2002

Filed:

Mar 12, 2002

Appl. No.:

10/095505

Inventors:

Megan Tran - Hoboken NJ
Gary P. Stack - Ambler PA

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 34741

US Classification:

514291, 546 90, 544234, 514248

Abstract:

Compounds of the formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

US Patent:

6525075, Feb 25, 2003

Filed:

Apr 25, 2002

Appl. No.:

10/131987

Inventors:

Megan Tran - Hoboken NJ
Gary P. Stack - Ambler PA

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31437

US Classification:

514338, 514321, 514322, 514300, 5462717, 546198, 546113

Abstract:

Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

US Patent:

6552049, Apr 22, 2003

Filed:

Apr 24, 2002

Appl. No.:

10/131340

Inventors:

Gary P. Stack - Ambler PA
Hong Gao - Plainsboro NJ
Elizabeth S. Gildersleeve - San Diego CA

Assignee:

Wyeth - Madison NJ

International Classification:

C07D40104

US Classification:

514338, 514321, 514300, 5462774, 546113, 546197

Abstract:

Compounds of the formula useful for the treatment of depression such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

US Patent:

6555560, Apr 29, 2003

Filed:

Apr 25, 2002

Appl. No.:

10/132238

Inventors:

Megan Tran - Hoboken NJ
Gary P. Stack - Ambler PA

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 314433

US Classification:

514338, 514321, 514300, 5462774, 546197, 546113

Abstract:

Compounds of the formula useful for the treatment of diseases such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

US Patent:

6559169, May 6, 2003

Filed:

Apr 23, 2002

Appl. No.:

10/128447

Inventors:

George E. M. Husbands - Berwyn PA
Gary P. Stack - Ambler PA
Richard E. Mewshaw - King of Prussia PA
Ian A. Cliffe - Farnham Common, GB

Assignee:

Wyeth - Madison NJ

International Classification:

C07D40104

US Classification:

514338, 514321, 514300, 5462774, 546197, 546113

Abstract:

Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

US Patent:

6573283, Jun 3, 2003

Filed:

Apr 23, 2002

Appl. No.:

10/128762

Inventors:

Gary P. Stack - Ambler PA

Assignee:

Wyeth - Madison NJ

International Classification:

C07D 4004

US Classification:

514338, 514300, 514322, 5462731, 546199, 546113

Abstract:

Compounds of the formula: are useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

US Patent:

6593350, Jul 15, 2003

Filed:

Apr 24, 2002

Appl. No.:

10/131339

Inventors:

Gary P. Stack - Ambler PA
Megan Tran - Hoboken NJ
Byron A. Bravo - Eagleville PA

Assignee:

Wyeth - Madison NJ

International Classification:

C07D49156

US Classification:

514338, 514300, 5462774, 546113

Abstract:

Compounds of the formula are useful in the treatment of central nervous system disorders including depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction, eating disorders and addictive disorders caused by ethanol or cocaine abuse.