Geoffrey W Henson

US Patent:

6365583, Apr 2, 2002

Filed:

Feb 1, 2000

Appl. No.:

09/495298

Inventors:

Ronald Trevor MacFarland - Vancouver, CA
Andrew W. Millar - Wallingford, GB
Gary Bridger - Bellingham WA
Michael J. Abrams - Custer WA
Geoffrey W. Henson - Ferndale WA

Assignee:

AnorMED, Inc. - Langley, British Columbia

International Classification:

A61K 3133

US Classification:

514183, 540473, 540474

Abstract:

Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed. These compounds have the formula or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; Zâ may be embodied in a form as defined by Z above, or alternatively may be of the formula wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; âlinkerâ represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms; in an amount effective to elevate said WBC count in said subject.

US Patent:

6670354, Dec 30, 2003

Filed:

Jan 4, 2002

Appl. No.:

10/039150

Inventors:

Ronald Trevor MacFarland - Vancouver, CA
Andrew W. Millar - Wallingford, GB
Gary Bridger - Bellingham WA
Michael J. Abrams - Custer WA
Geoffrey W. Henson - Ferndale WA

Assignee:

AnorMed, Inc. - Langley

International Classification:

A61K 3133

US Classification:

514183, 540473, 540474

Abstract:

Methods to elevate white blood cell counts in animal subjects using compounds of formula (1) are disclosed. These compounds have the formula or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; Zâ may be embodied in a form as defined by Z above, or alternatively may be of the formula âwherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; âlinkerâ represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms; in an amount effective to elevate said WBC count in said subject.

US Patent:

6987102, Jan 17, 2006

Filed:

Jul 30, 2002

Appl. No.:

10/209001

Inventors:

Gary J. Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Assignee:

Anormed, Inc. - Langley

International Classification:

A61K 31/33
C07D 245/00
C07D 487/00

US Classification:

514183, 540473, 540474

Abstract:

Certain nitrogen-containing compounds that bind the chemokine receptor CXCR4 are able to mobilize progenitor and/or stem cells into the peripheral blood to permit harvesting them for stem cell transplantation.

US Patent:

7169750, Jan 30, 2007

Filed:

Jun 5, 2003

Appl. No.:

10/456942

Inventors:

Gary Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald T. MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US

Assignee:

Anormed, Inc. - Langley

International Classification:

A61K 38/00
A61K 31/44
A61K 31/40

US Classification:

514 2, 514357, 514408, 514649

Abstract:

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulaZ-linker-Z′   (1).

US Patent:

7897590, Mar 1, 2011

Filed:

Aug 20, 2007

Appl. No.:

11/841837

Inventors:

Gary J. Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/33
C07D 245/00
C07D 487/00

US Classification:

514183, 540473, 540474

Abstract:

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulaZ-linker-Z′  (1).

US Patent:

7935692, May 3, 2011

Filed:

Nov 8, 2005

Appl. No.:

11/269773

Inventors:

Gary J. Bridger - Bellingham WA, US
Michael J. Abrams - Custer WA, US
Geoffrey W. Henson - Ferndale WA, US
Ronald Trevor MacFarland - Vancouver, CA
Gary B. Calandra - Cresco PA, US
Hal E. Broxmeyer - Indianapolis IN, US
David C. Dale - Seattle WA, US

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

A61K 31/33
C07D 245/00
C07D 487/00

US Classification:

514183, 540473, 540474

Abstract:

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulaZ-linker-Z′  (1).

US Patent:

20050250801, Nov 10, 2005

Filed:

Mar 10, 2004

Appl. No.:

10/796292

Inventors:

Kunwar Shailubhai - Norristown PA, US
Gary Jacob - New York NY, US
Donald Picker - Forrest Hills NY, US
Geoffrey Henson - Ferndale WA, US
Simon Fricker - Langley, CA

International Classification:

A61K031/4747
A61K031/403

US Classification:

514278000, 514409000

Abstract:

A method of treating cancer by administering a therapeutically effective amount of a compound represented by the following Formula (I), or salt, hydrate, or solvate thereof: wherein: n represents a number from 3 to 7; m represents a number from 1 to 2;

US Patent:

20060223180, Oct 5, 2006

Filed:

Jun 2, 2006

Appl. No.:

11/446390

Inventors:

Gary Bridger - Bellingham WA, US
Michael Abrams - Custer WA, US
Geoffrey Henson - Ferndale WA, US
Ronald MacFarland - Vancouver, CA
Gary Calandra - Cresco PA, US
Hal Broxmeyer - Indianapolis IN, US
David Dale - Seattle WA, US

International Classification:

A61K 31/33
C12N 5/08

US Classification:

435366000, 514183000

Abstract:

Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z′  () or pharmaceutically acceptable salt thereof wherein Z is a cyclic polyamine containing 9-32 ring members of which 3-8 are nitrogen atoms, said nitrogen atoms separated from each other by at least 2 carbon atoms, and wherein said heterocycle may optionally contain additional heteroatoms besides nitrogen and/or may be fused to an additional ring system; or Z is of the formula wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1-20 atoms, Z′ may be embodied in a form as defined by Z above, or alternatively may be of the formula —N(R)—(CR)—X wherein each R is independently H or straight, branched or cyclic alkyl (1-6C), n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; “linker” represents a bond, alkylene (1-6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.