George J Christ

US Patent:

7030096, Apr 18, 2006

Filed:

Mar 21, 2000

Appl. No.:

09/531969

Inventors:

Jan Geliebter - Brooklyn NY, US
George J. Christ - Smithtown NY, US
Arnold Melman - Ardsley NY, US
Jamil Rehman - Bronx NY, US

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

A01N 43/04
A01N 63/00
A01N 65/00
A61K 31/70
C12N 15/00

US Classification:

514 44, 424 931, 4353201, 435325, 435455, 536 231

Abstract:

The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

US Patent:

D564213, Mar 18, 2008

Filed:

Apr 30, 2007

Appl. No.:

29/279392

Inventors:

George Christ - Garden City NY, US

International Classification:

0301

US Classification:

D 3201

US Patent:

D589701, Apr 7, 2009

Filed:

Apr 8, 2008

Appl. No.:

29/306341

Inventors:

George Christ - Garden City NY, US

International Classification:

0301

US Classification:

D 3247

US Patent:

D667630, Sep 25, 2012

Filed:

Oct 12, 2011

Appl. No.:

29/403914

Inventors:

George Christ - Garden City NY, US

International Classification:

0301

US Classification:

D 3215

US Patent:

20070086982, Apr 19, 2007

Filed:

Dec 1, 2005

Appl. No.:

11/291481

Inventors:

Jan Geliebter - Brooklyn NY, US
George Christ - Smithtown NY, US
Arnold Melman - Ardsley NY, US
Jamil Rehman - Bronx NY, US

International Classification:

A61K 48/00
A61K 9/127
C12N 15/86
C12N 15/88
C12N 15/87

US Classification:

424093200, 514044000, 424450000, 435458000, 435459000, 435456000

Abstract:

The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

US Patent:

62391178, May 29, 2001

Filed:

Mar 21, 2000

Appl. No.:

9/531968

Inventors:

George J. Christ - Smithtown NY
Arnold Melman - Ardsley NY

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

A01N 4304
A61K 3170

US Classification:

514 44

Abstract:

The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

US Patent:

6150338, Nov 21, 2000

Filed:

Feb 13, 1997

Appl. No.:

8/799144

Inventors:

Jan Geliebter - Brooklyn NY
Arnold Melman - Ardsley NY
George J. Christ - Smithtown NY
Jamil Rehman - Bronx NY

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

A61K 4800
C12N 1585
C07H 2104

US Classification:

514 44

Abstract:

The present invention is directed towards gene therapy for erectile dysfunction through delivery and expression of a recombinant vector containing a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a smooth muscle cell. Also provided by the present invention is a method of inducing penile erection in a subject comprising the introduction and expression of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone into a sufficient number of cells of the subject to induce penile erection in the subject. The present invention also provides a recombinant vector comprising the DNA of or corresponding to at least a portion of the genome of a virus, which portion is capable of directing the expression of a DNA sequence, and DNA encoding a protein involved in the regulation of smooth muscle tone operably linked to the viral DNA and capable of being expressed as a functional gene product in the target cell. Also provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.

US Patent:

6271211, Aug 7, 2001

Filed:

Mar 21, 2000

Appl. No.:

9/532138

Inventors:

George J. Christ - Smithtown NY
Arnold Melman - Ardsley NY

Assignee:

Albert Einstein College of Medicine of Yeshiva University - Bronx NY

International Classification:

A01N 4304
A61K 3170
C12N 1500
C12N 1509
C12N 1563

US Classification:

514 44

Abstract:

The present invention is directed towards a method of regulating smooth muscle tone, comprising the introduction, into smooth muscle cells of a subject, of a DNA sequence encoding a protein involved in the regulation of smooth muscle tone, and expression of the DNA sequence in a sufficient number of smooth muscle cells of the subject to regulate smooth muscle tone in the subject. Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle tone. Further provided by the present invention is a smooth muscle cell which expresses a gene encoding a protein involved in the regulation of smooth muscle tone.