George J Corey

US Patent:

6346210, Feb 12, 2002

Filed:

Feb 13, 1998

Appl. No.:

09/023740

Inventors:

Henry D. Swartz - Chestnut Hill MA
Gary P. Magnant - Rockport MA
George Corey - Newton MA

Assignee:

The Rockport Company, LLC - Canton MA

International Classification:

B29C 3508

US Classification:

264486, 264320, 264321, 264413, 264487, 264489, 264490, 264496

Abstract:

A susceptor-impregnated thermoplastic foam is molded by heating the susceptor-impregnated thermoplastic foam, preferably by induction; imprinting an object against the foam; and allowing the foam to cool into a hardened form conformed to the object.

US Patent:

6709869, Mar 23, 2004

Filed:

Nov 20, 2001

Appl. No.:

09/989582

Inventors:

Alec Mian - Cambridge MA
Stephen G. Kieffer-Higgins - Dorchester MA
George D. Corey - Newton MA

Assignee:

Tecan Trading AG

International Classification:

G01N 3500

US Classification:

436 45, 436 43, 436 63, 436 66, 436 70, 422 50, 422 64, 422 63, 422 67, 422 72

Abstract:

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem platforms of the invention are also optionally provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

US Patent:

6812271, Nov 2, 2004

Filed:

Dec 21, 2001

Appl. No.:

10/024362

Inventors:

Henry D. Swartz - Chestnut Hill MA
Gary P. Magnant - Rockport MA
George Corey - Newton MA

Assignee:

The Rockport Company, LLC - Canton MA

International Classification:

C08K 328

US Classification:

524430, 521 92, 524434

Abstract:

A susceptor-impregnated thermoplastic foam is molded by heating the susceptor-impregnated thermoplastic foam, preferably by induction; imprinting an object against the foam; and allowing the foam to cool into a hardened form conformed to the object.

US Patent:

6919076, Jul 19, 2005

Filed:

Jul 22, 1999

Appl. No.:

09/359920

Inventors:

Howard Green - Brookline MA, US
Bruce Compton - Lexington MA, US
George Corey - Newton MA, US
Philippe Djian - Paris, FR

Assignee:

Pericor Science, Inc. - Boston MA

International Classification:

A61K038/00
A61K038/45
A61K038/48
C12N011/02
C07K017/02

US Classification:

424 945, 424 59, 424 946, 424 9463, 424401, 435 16, 435177, 435193, 435196, 514 2, 530402, 530812

Abstract:

Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as cholinesterase or phosphodiesterase. The transglutaminase may be exogenously added or be endogenous in tissue. In specific embodiments, the agent is not a transglutaminase substrate and the linking molecule is a substrate for transglutaminase containing at least two contiguous linked glutamines or at least three contiguous linked lysines, and may be a polymer. A conjugate of the agent and the linking molecule may be applied to tissue, and in the presence of transglutaminase covalently bonded to the tissue via the linking molecule. A complementary linking molecule rich in lysines may be first attached to the tissue in the presence of transglutaminase, and then covalently bonded to a glutamine-containing linking molecule of the conjugate in the presence of transglutaminase. In another embodiment a linking molecule containing multiple glutamines is covalently bonded to tissue in the presence of transglutaminase, and an agent containing multiple lysines is covalently bonded to the linking molecule in the presence of transglutaminase.

US Patent:

6958148, Oct 25, 2005

Filed:

Jul 21, 2000

Appl. No.:

09/620783

Inventors:

Howard Green - Brookline MA, US
Bruce J. Compton - Lexington MA, US
George D. Corey - Newton MA, US
Philippe Djian - Paris, FR

Assignee:

Pericor Science, Inc. - Boston MA

International Classification:

A61K038/45
A61K038/48
A61K038/00
C12N011/02
C07K017/02

US Classification:

424 945, 424 59, 424 9463, 424401, 435 16, 435177, 435193, 514 2, 530402, 530812

Abstract:

Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the groups are part of a polymer containing at least two contiguous linked lysines or at least three contiguous linked glutamines.

US Patent:

20010055812, Dec 27, 2001

Filed:

Dec 5, 1996

Appl. No.:

08/761063

Inventors:

ALEC MIAN - CAMBRIDGE MA, US
STEPHEN G. KIEFFER-HIGGINS - DORCHESTER MA, US
GEORGE D. COREY - NEWTON MA, US

International Classification:

B01L003/02

US Classification:

436/045000, 422/064000, 422/067000, 422/072000

Abstract:

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem platforms of the invention are also provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

US Patent:

20050069913, Mar 31, 2005

Filed:

Mar 23, 2004

Appl. No.:

10/808256

Inventors:

Alec Mian - Cambridge MA, US
Stephen Kieffer-Higgins - Dorchester MA, US
George Corey - Newton MA, US

International Classification:

C12Q001/68
G11B005/596
C12M001/34

US Classification:

435006000, 435287200

Abstract:

This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force resulting from rotation of the platform to motivate fluid movement through microchannels. The microsystem, platforms of the invention are also optionally provided having system informatics and data acquisition, analysis and storage and retrieval informatics encoded on the surface of the disk opposite to the surface containing the fluidic components. Methods specific for the apparatus of the invention for performing any of a wide variety of microanalytical or microsynthetic processes are provided.

US Patent:

20060104966, May 18, 2006

Filed:

Jun 3, 2005

Appl. No.:

11/144372

Inventors:

Howard Green - Brookline MA, US
Bruce Compton - Lexington MA, US
George Corey - Newton MA, US
Philippe Djian - Paris, FR

Assignee:

Pericor Science, Inc. - Boston MA

International Classification:

A61K 38/48

US Classification:

424094500

Abstract:

Methods, products and kits are provided for attaching agents to body tissues using transglutaminase.