George S Ehrlich

US Patent:

7642244, Jan 5, 2010

Filed:

Dec 1, 2006

Appl. No.:

11/607230

Inventors:

Waleed Danho - Wayne NJ, US
George Ehrlich - New York NY, US
Nader Fotouhi - Basking Ridge NJ, US
David Charles Fry - Langhorne PA, US
Wajiha Khan - East Hanover NJ, US
Anish Konkar - Guttenberg NJ, US
Cristina Martha Rondinone - West Milford NJ, US
Joseph Swistok - Nutley NJ, US
Rebecca Anne Taub - Villanova PA, US
Jefferson Wright Tilley - North Caldwell NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 38/10
C07K 7/08

US Classification:

514 13, 514 14, 530326, 930 20

Abstract:

Provided herein are neuropeptide-2 receptor agonists of the formula (I):.

US Patent:

8268784, Sep 18, 2012

Filed:

Aug 6, 2009

Appl. No.:

12/536688

Inventors:

Waleed Danho - Wayne NJ, US
George Ehrlich - New York NY, US
Nader Fotouhi - Basking Ridge NJ, US
David Charles Fry - Langhorne PA, US
Wajiha Khan - East Hanover NJ, US
Anish Konkar - Guttenberg NJ, US
Cristina Martha Rondinone - West Milford NJ, US
Joseph Swistok - Nutley NJ, US
Rebecca Anne Taub - Villanova PA, US
Jefferson Wright Tilley - North Caldwell NJ, US

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 38/10
C07K 7/08

US Classification:

514 181, 514 52, 514 69, 514 215, 530326, 930 20, 930 30

Abstract:

Provided herein are neuropeptide-2 receptor agonists of the formula (I):.

US Patent:

20060160742, Jul 20, 2006

Filed:

Jan 10, 2006

Appl. No.:

11/328743

Inventors:

Waleed Danho - Wayne NJ, US
George Ehrlich - New York NY, US
David Fry - Langhorne PA, US
Wajiha Khan - East Hanover NJ, US
Joseph Swistok - Nutley NJ, US

International Classification:

A61K 38/10
C07K 7/08

US Classification:

514014000, 530327000, 530326000

Abstract:

Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R—R—X—R—R—R—R—R—R—R—R—R—R—R—R—NH  (I), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

US Patent:

20130324531, Dec 5, 2013

Filed:

May 29, 2013

Appl. No.:

13/904153

Inventors:

Xin-Jie Chu - Shanghai, CN
George Kenneth Ehrlich - Bronx NY, US
Jin-Jun Liu - Warren Township NJ, US
Hanspeter Michel - Bloomfield NJ, US
Binh Thanh Vu - North Caldwell NJ, US
Chunlin Zhao - Shanghai, CN

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D 207/16
C07H 17/02
C07D 401/12
C07F 9/572
C07D 405/12

US Classification:

5142355, 548537, 548413, 548517, 546208, 544372, 546117, 544141, 514423, 514326, 514300, 514422, 514 91, 51425401, 536 174, 514 25

Abstract:

There are provided compounds of the formulawherein X, Y, Z, R, Rand Rare as described hereinand enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.