George Daniel Field

US Patent:

52567990, Oct 26, 1993

Filed:

Jul 14, 1992

Appl. No.:

7/913084

Inventors:

George F. Field - Danville CA
Peter R. Hammond - Livermore CA

Assignee:

The United States of Americas as represented by the United States
Department of Energy - Washington DC

International Classification:

C07D21520

US Classification:

548469

Abstract:

A novel method for the synthesis of 6-hydroxyindolines and new fluorescent dyes produced therefrom, which dyes are ring-constrained indoline-based rhodamine class dyes. These dyes have absorption and emission spectra which make them particularly useful in certain dye laser applications.

US Patent:

52833364, Feb 1, 1994

Filed:

Sep 8, 1992

Appl. No.:

7/941813

Inventors:

George Field - Danville CA
Peter R. Hammond - Livermore CA

Assignee:

The United States of America as represented by the United States
Department of Energy - Washington DC

International Classification:

C07D21520

US Classification:

546179

Abstract:

Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

US Patent:

50011405, Mar 19, 1991

Filed:

Jun 13, 1989

Appl. No.:

7/366097

Inventors:

George F. Field - Danville CA
John R. Vermeulen - Wanaque NJ
William J. Zally - Cresskill NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07D27730
A61K 31425

US Classification:

514365

Abstract:

The invention relates to compounds of the formula: ##STR1## wherein R is hydrogen or lower alkyl, R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4, independently, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl or phenyl unsubstituted or substituted by up to 3 substituents independently selected from lower alkyl, lower alkoxy or halogen, or R. sub. 1 and R. sub. 2 taken together with the carbon atom are alkylene of 2 to 5 carbon atoms unsubstituted or substituted by lower alkyl, and n is an integer of from 0 to 3, and, when R. sub. 1 is different from R. sub. 2 and/or when R. sub. 3 is different from R. sub. 4, enantiomers, diastereomers and racemates thereof and, when R is hydrogen, salts thereof with pharmaceutically acceptable bases. The compounds of formula I and, when R is hydrogen, pharmaceutically exceptable salts thereof are useful as bronchopulmonary agents, for example, in the relief of asthma and allergic reactions.