George C Nelson

US Patent:

20100297660, Nov 25, 2010

Filed:

Jan 30, 2009

Appl. No.:

12/864218

Inventors:

Cheryl Winkler - Gaithersburg MD, US
George Nelson - Thurmont MD, US
Jeffrey B. Kopp - Bethesda MD, US
Michael W. Smith - Jefferson MD, US
Randall Johnson - Frederick MD, US

International Classification:

C12Q 1/68
C40B 40/06

US Classification:

435 6, 506 16

Abstract:

Methods for determining the genetic predisposition of a human subject to developing renal disease, such as focal segmental glomerulosclerosis (FSGS) or end-stage kidney disease are provided herein. These methods include methods for detecting renal disease, or determining the risk of developing renal disease in a human subject, such as a subject of African ancestry. The methods utilize the detection of one or more haplotype blocks comprising at least two tag single nucleotide polymorphisms (SNPs) in a non-coding region of a MYH9 gene or detecting the presence of at least one tag SNP in a non-coding region of a MYH9 gene. An array for detecting a genetic predisposition to renal disease using probes complementary to the tag SNPs in the non-coding region of the MYH9 gene are also disclosed.

US Patent:

46688285, May 26, 1987

Filed:

May 6, 1983

Appl. No.:

6/492087

Inventors:

George L. Nelson - Narberth PA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C07C 4570

US Classification:

568353

Abstract:

A method for oligomerization of a group of prostaglandin analogs such as Ethyl Analog 3-(trans-3-keto-1-pentenyl)-2-ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate soluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution with exposure to atmospheric oxygen at moderate conditions of temperature, time and concentration.

US Patent:

43384668, Jul 6, 1982

Filed:

Apr 2, 1981

Appl. No.:

6/250366

Inventors:

George L. Nelson - Narberth PA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C07C 49597
C07C 4545

US Classification:

568343

Abstract:

Prostaglandin analogs and process for the preparation thereof as precursors or the synthesis of oligomeric mixtures exhibiting biological activity for protection of oxidative phosphorylation of degraded mitochondria. The analogs have the general formula: ##STR1## synthesized by O-alkylating a 2-alkylcyclopentane-1,3-dione to form an enol ether, reacting the ether with CH. sub. 2. dbd. CHMgBr to form a vinyl, oxidizing the vinyl with OsO. sub. 4 and NaIO. sub. 4 to form an aldehyde, and reacting the aldehyde with a sodium salt of dimethyl (2-oxoalkyl)phosphonate.

US Patent:

44706472, Sep 11, 1984

Filed:

Jun 1, 1982

Appl. No.:

6/383702

Inventors:

Mark L. Bishoff - Columbia MD
George Nelson - New York NY
Daniel J. Lewis - Ridgewood NJ

International Classification:

A47B 8700

US Classification:

312111

Abstract:

A set of identical connectors are secured to a plurality of rectangular panels to form a tubular or box-like storage unit with the connectors forming parallel longitudinal edges thereof. The connectors each have a longitudinal T-shaped rib and a T-shaped, longitudinal recess, capable of slideably receiving the rib of an adjacent storage unit, so that a plurality of units may be arranged and stacked to form a self sustaining structure from which one or more storage units may be slideably removed without disturbance to the remaining structure and units. In one embodiment a connector and a panel are formed integrally as a one-piece unit.

US Patent:

46634860, May 5, 1987

Filed:

May 6, 1983

Appl. No.:

6/492088

Inventors:

George L. Nelson - Narberth PA

Assignee:

The United States of America as represented by the Secretary of the Navy - Washington DC

International Classification:

C07C 4570

US Classification:

568353

Abstract:

A method for oligomerization of a group of prostaglandin analogs such as Ethyl Analog 3-(trans-3-keto-1-pentenyl)-2-ethyl-2-cyclopentenone into a biologically active exhibiting protection of oxidative phosphorylation of degenerated mitochondria and sodium bicarbonate insoluble oligomeric mixtures is described. The Ethyl Analog is treated with ethanolic potassium hydroxide solution in an oxygen-free atomsphere at moderate conditions of temperature, time and concentration.