Megumi Kawai - Libertyville IL Jack Henkin - Highland Park IL George S. Sheppard - Wilmette IL Richard A. Craig - Racine WI
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07K 6500
US Classification:
562405, 514 19, 562553, 562562
Abstract:
Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
Antiangiogenic Drug To Treat Cancer, Arthritis And Retinopathy
Megumi Kawai - Libertyville IL, US Jack Henkin - Highland Park IL, US George S. Sheppard - Wilmette IL, US Richard A. Craig - Racine WI, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07C 6976
US Classification:
560102, 560 41, 562492, 564169
Abstract:
Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.
Richard A. Craig - Racine WI, US Megumi Kawai - Libertyville IL, US Linda M. Lynch - Pleasant Prairie WI, US Jyoti R. Patel - Libertyville IL, US George S. Sheppard - Wilmette IL, US Jieyi Wang - Lake bluff IL, US Fan Yang - Highwood IL, US Nwe Ba-Maung - Niles IL, US Xenia Beebe Searle - Grayslake IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
A61K031/33 A61K031/16 A61K031/20
US Classification:
514183, 514614, 514615, 514558
Abstract:
Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.
3-Amino-2-Hydroxyalkanoic Acids And Their Prodrugs
Nwe Y. BaMaung - Niles IL, US Richard A. Craig - Racine WI, US Jack Henkin - Highland Park IL, US Megumi Kawai - Libertyville IL, US Xenia B. Searle - Grayslake IL, US George S. Sheppard - Wilmette IL, US Jieyi Wang - Lake Bluff IL, US
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07C 331/00
US Classification:
560 19, 560155, 562433, 562553
Abstract:
Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
Sulfonamides Having Antiangiogenic And Anticancer Activity
Kenneth M. Comess - Winnetka IL, US Scott A. Erickson - Zion IL, US Jack Henkin - Highland Park IL, US Douglas M. Kalvin - Buffalo Grove IL, US Megumi Kawai - Libertyville IL, US Ki H. Kim - Vista CA, US Nwe Y. BaMaung - Niles IL, US Chang Hoon Park - Libertyville IL, US George S. Sheppard - Wilmette IL, US Anil Vasudevan - Gurnee IL, US Jieyi Wang - Lake Bluff IL, US David M. Barnes - Lake Villa IL, US Steve D. Fidanze - Grayslake IL, US Lawrence Kolaczkowski - Gurnee IL, US Robert A. Mantei - Franklin WI, US David C. Park - Urbana IL, US William J. Sanders - Fox Lake IL, US Jason S. Tedrow - Evanston IL, US Gary T. Wang - Libertyville IL, US
Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.
Substituted Pyrazolo[3,4-D]Pyrimidines As Protein Kinase Inhibitors
George S. Sheppard - Wilmette IL, US Gary T. Wang - Libertyville IL, US Fabio Palazzo - Libertyville IL, US Randy L Bell - Lindenhurst IL, US Robert A. Mantei - Franklin WI, US Jieyi Wang - Lake Bluff IL, US Robert D. Hubbard - Lindenhurst IL, US Megumi Kawai - Libertyville IL, US Scott A. Erickson - Zion IL, US Nwe BaMaung - Niles IL, US Steve D. Fidanze - Grayslake IL, US
Compounds of formula (25) that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Nwe Y. Ba-Maung - Niles IL, US Randy L. Bell - Lindenhurst IL, US Richard F. Clark - Gurnee IL, US Scott A. Erickson - Zion IL, US Steve D. Fidanze - Grayslake IL, US Robert D. Hubbard - Lindenhurst IL, US Robert A. Mantei - Franklin WI, US George S. Sheppard - Wilmette IL, US Bryan K. Sorensen - Antioch IL, US Gary T. Wang - Libertyville IL, US Jieyi Wang - Lake Bluff IL, US
Richard F. Clark - Gurnee IL, US Randy L. Bell - Lindenhurst IL, US Nwe Y. Ba-maung - Niles IL, US Scott A. Erickson - Zion IL, US Steve D. Fidanze - Grayslake IL, US Robert A. Mantei - Franklin WI, US George S. Sheppard - Wilmette IL, US Bryan K. Sorensen - Antioch IL, US Gary T. Wang - Libertyville IL, US Jieyi Wang - Lake Bluff IL, US
Assignee:
Abbott Laboratories Inc. - Abbott Park IL
International Classification:
C07D 403/14 C07D 413/14 A61K 31/5377 A61K 31/506
US Classification:
514275, 514248, 544235, 544333
Abstract:
The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof,.
Abbvie
Senior Principal Research Scientist at Abbvie
Abbvie Jan 2013 - Jun 2016
Principal Research Scientist
Abbott Jun 1990 - Dec 2012
Assoc Research Fellow
Harvard University Jul 1988 - May 1990
Nih Postdoctoral Fellow
Education:
University of California, Berkeley 1984 - 1988
Doctorates, Doctor of Philosophy, Chemistry
Oberlin College 1980 - 1984
Bachelors, Bachelor of Arts, Economics, Chemistry
Harvard University
Skills:
Medicinal Chemistry Organic Synthesis Drug Discovery Drug Design Organic Chemistry Lc Ms Lead Change Life Sciences Nmr Chemistry Hplc Pharmaceutical Industry Chromatography Drug Development
Interests:
Kids Cooking Collecting Antiques Investing Outdoors Sweepstakes Electronics Home Improvement Shooting Reading Sports The Arts Collecting Home Decoration
m.Sheppard bring indie-pop vibes to the Hot 100 stage straight from their native Brisbane, with frontman George Sheppard telling the crowd it took 30 hours of travel to make it to New York. Theres no sign of jet-lag here: The band, of which three members are siblings, rip through Hometown, Kee
Echoing that familial support theme were Brisbane-based Sheppard, who won for best group off the strength of second album Bombs Away and the smash hit Geronimo. Lead vocalist George Sheppard said of his lawyer father, I dont think he ever wanted us to follow in his footsteps. I had one conversat