Gerald M Carlson

US Patent:

20110008461, Jan 13, 2011

Filed:

Jul 12, 2010

Appl. No.:

12/834609

Inventors:

Gerald Carlson - Kansas City MO, US
Todd Holyoak - Lenexa KS, US
Sarah Sullivan - Lenexa KS, US
Rose Mary Stiffin - Opa Locka FL, US

International Classification:

A61K 31/194
C07C 59/347
C07D 319/12
C07D 213/79
C07D 491/052
A61K 31/357
A61K 31/44
A61K 31/436
C07D 265/06
A61K 31/535
C07D 239/38
A61K 31/505
C07C 55/06
C07C 55/08
C07C 55/10
A61K 31/205
C07C 229/24
A61K 31/675
A61K 31/661
C07F 9/145
C07F 9/38
A61K 31/665
C07C 309/05
A61K 31/185
A61K 31/663
A61K 33/42
A61P 3/10
C01B 25/12

US Classification:

424605, 562578, 549379, 546298, 546116, 514574, 514452, 514350, 514302, 544 97, 5142288, 544298, 514269, 562597, 562590, 514556, 562571, 514 86, 514 89, 514 90, 514132, 558193, 558210, 514143, 549217, 514 99, 562101, 514553, 562 21, 562 20, 514108, 423304

Abstract:

A PEPCK inhibitor can include identifying a molecule that has a size capable of fitting into and interacting with the PEPCK binding site and at least one of the following: (a) a first terminal substituent having co-planar atoms acting as metal ligands to the active site metal ion PEPCK; (b) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent includes a neutral carbon center or include an oxygen, sulfur, selenium, or other atom with similar physiochemical properties; (c) at least one of an atom or substituent at positions 2 or 3 from the first terminal substituent is devoid of an electropositive atom or substituents; or (d) a second terminal substituent opposite of the first terminal substituent, said second terminal substituent having an atom that is a hydrogen boding acceptor and/or is negatively charged.