Gerald P O'Neill

US Patent:

49613219, Oct 9, 1990

Filed:

Feb 28, 1989

Appl. No.:

7/316627

Inventors:

Gerald J. O'Neill - Arlington MA
Robert S. Holdsworth - Arlington MA

Assignee:

W. R. Grace & Co.-Conn. - New York NY

International Classification:

C09K 502

US Classification:

62114

Abstract:

A chlorine-free refrigerant comprised of bis (difluoromethyl)ether; CHF. sub. 2 OCHF. sub. 2. The refrigerant may be used alone or in combination with other refrigerants. The bis (difluoromethyl) ether refrigerant is environmentally safe, non toxic, non flammable and has the desired physical, chemical and thermodynamic properties necessary for a refrigerant.

US Patent:

39326691, Jan 13, 1976

Filed:

Jan 10, 1975

Appl. No.:

5/539958

Inventors:

Robert S. Holdsworth - Arlington MA
Gerald J. O'Neill - Arlington MA
Paul Tarrant - Gainesville FL

Assignee:

W. R. Grace & Co. - Cambridge MA

International Classification:

A61K 31025

US Classification:

424352

Abstract:

The compound 1-chloro-2,2-dimethyl-1,4,4-trifluorocyclobutane has been found to possess useful properties as a general inhalation anesthetic.

US Patent:

58115846, Sep 22, 1998

Filed:

Jul 29, 1997

Appl. No.:

8/902460

Inventors:

Gerald J. O'Neill - Arlington MA
Albert H. Levesque - Nashua NH
Robert J. Bulka - Merrimack NH

Assignee:

Hampshire Chemical Corp. - Lexington MA

International Classification:

C07C20900

US Classification:

564494

Abstract:

Process for the production of TMEDA in high yield by reducing 2,3-dimethyl-2,3-dinitrobutane with hydrogen in the presence of a chromium promoted Raney cobalt catalyst. A solution of 2,3-dimethyl-2,3-dinitrobutane in a suitable solvent is fed to a reactor while avoiding the accumulation of 2,3-dimethyl-2,3-dinitrobutane in the reaction medium, such as by feeding it at a rate no greater than its rate of reaction with hydrogen. In a preferred embodiment, the resulting TMEDA is recovered by converting it to an amine salt by sparging carbon dioxide through the solution.

US Patent:

56167725, Apr 1, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/466095

Inventors:

Gerald J. O'Neill - Arlington MA
Albert H. Levesque - Nashua NH

Assignee:

Hampshire Chemical Corp. - Lexington MA

International Classification:

C07C40900

US Classification:

558304

Abstract:

A method of stabilizing nitriles, and in particular iminodiacetonitrile (IDAN), ethylendiamine-triacetonitrile (EDTN), and especially nitrilotriacetonitrile (NTAN). The present invention also encompasses the resulting stabilized nitrile. The method of the present invention comprises contacting the nitrile with a mixture of silica and alumina, zeolites or glass.

US Patent:

50970720, Mar 17, 1992

Filed:

Mar 21, 1991

Appl. No.:

7/674860

Inventors:

Gerald J. O'Neill - Arlington MA
Albert H. Levesque - Nashua NH

Assignee:

W.R. Grace & Co.-Conn. - New York NY

International Classification:

C07C 4544

US Classification:

564491

Abstract:

Polyamines are prepared via the batchwise hydrogenation of polynitriles by the gradual addition of the polynitrile into a fed-batch reactor which contains chromium promoted Raney. RTM. cobalt catalyst. The hydrogenation optionally is conducted in the presence of anhydrous ammonia. The polyamine product having amino groups which corresponds to the nitrile of the polynitrile is economically obtained in high selectivity and yield as the dominant product.

US Patent:

54462118, Aug 29, 1995

Filed:

Apr 1, 1994

Appl. No.:

8/221498

Inventors:

Gerald J. O'Neill - Arlington MA
Robert J. Bulka - Merrimack NH

Assignee:

Hampshire Chemical Corp. - Lexington MA

International Classification:

C07C 4100
C07C 4300

US Classification:

568684

Abstract:

The synthesis of fluorinated dimethyl ethers of the formula CF. sub. 2 HOCCl. sub. x F. sub. y H. sub. 3-(x+y) wherein x is 0, 1 or 2; y is 1, 2 or 3; and wherein (x+y) is 1, 2 or 3. The process involves chlorination of methyl difluoromethyl ether in the presence of a solvent to form a chlorinated reaction product of the formula CF. sub. 2 HOCH. sub. 3-z Cl. sub. z wherein z is 1, 2 or 3. The process may also be carried out in the presence of oxygen in order to inhibit the formation of CF. sub. 2 HOCCl. sub. 3. The resulting compound(s) is then fluorinated with HF before or after separation, to give a fluorinated reaction product including the aforementioned fluorinated dimethyl ethers.

US Patent:

39548937, May 4, 1976

Filed:

Jan 10, 1975

Appl. No.:

5/539957

Inventors:

Gerald J. O'Neill - Arlington MA
Robert S. Holdsworth - Arlington MA
Charles W. Simons - Bedford MA

Assignee:

W. R. Grace & Co. - Cambridge MA

International Classification:

C07C 2306

US Classification:

260648F

Abstract:

Certain new halogenated cyclobutanes have been synthesized and found to possess utility as inhalation anesthetics. They are: 1,4-dichloro-1,2,2-trifluorocyclobutane, 1-chloro-1,2,2,4-tetrafluorocyclobutane, 1,4-dichloro-1,2,2,4-tetrafluorocyclobutane, 1-chloro-1,2,2,3,3-pentafluorocyclobutane, 1,2,2-trifluorocyclobutane, 1-chloro-2,3,3-trifluorocyclobutane, 1-chloro-2,4 4-trifluorocyclobutane, 1-bromo-1,2,2-trifluorocyclobutane, 1-bromo-2-methyl-1,4,4-trifluorocyclobutane and 1-bromo-2-chloro-1,4,4-trifluorocyclobutane.

US Patent:

52783421, Jan 11, 1994

Filed:

Mar 15, 1993

Appl. No.:

8/025009

Inventors:

Gerald J. O'Neill - Arlington MA
Robert J. Bulka - Merrimack NH

Assignee:

Hampshire Chemical Corp. - Lexington MA

International Classification:

C07C 4122

US Classification:

568684

Abstract:

The synthesis of fluorinated dimethyl ethers of the formula CF. sub. 2 HOCCl. sub. x F. sub. y H. sub. 3-(x+y) wherein x is 0, 1 or 2; y is 1, 2 or 3; and wherein (x+y) is 1, 2 or 3. The process involves chlorination of methyl difluoromethyl ether in the presence of oxygen to form a chlorinated reaction product of the formula CF. sub. 2 HOCH. sub. 3-z Cl. sub. z wherein z is 1 or 2, and wherein the formation of CF. sub. 2 HOCCl. sub. 3 is inhibited. The resulting compound(s) is then fluorinated with HF before or after separation, to give a fluorinated reaction product including the aforementioned fluorinated dimethyl ethers.