Gerald Robert O'Neill

US Patent:

39898458, Nov 2, 1976

Filed:

Dec 26, 1974

Appl. No.:

5/536589

Inventors:

Charles Alden Billings - Concord MA
Gerald Joseph O'Neill - Arlington MA
Charles William Simons - Bedford MA
Robert S. Holdsworth - Arlington MA

Assignee:

W. R. Grace & Co. - Cambridge MA

International Classification:

H61K 31025

US Classification:

424352

Abstract:

The following chlorocyclopropanes have been found to possess utility as general inhalation anesthetics: 1,1-dichloro-2-methyl-2,3,3-trifluorocyclopropane, 1,2-dichloro-1-fluoro-2-methylcyclopropane, 1,1,2-trichloro-2,3,3-trifluorocyclopropane, 1,1-dichloro-2-trifluoromethyl-2,3,3-trifluorocyclopropane, 1,2-dichloro-1,2,3,3-tetrafluorocyclopropane, 1,1,2,2-tetrachloro-3,3-difluorocyclopropane and 1,1-dichloro-2,3,3-trifluorocyclopropane. THE PRIOR ART In the continuing search for general inhalation anesthetics, there has been recently discovered a few halocyclopropanes and methylhalocyclopropanes and some methyl halocycloproyl ethers. These compounds are disclosed in U. S. Pat. Nos. 3,865,950, 3,839,589 and 3,769,429 as well as in pending applications Ser. No. 499,761 (filed Aug.

US Patent:

39313441, Jan 6, 1976

Filed:

Dec 26, 1974

Appl. No.:

5/536573

Inventors:

Charles Alden Billings - Concord MA
Gerald Joseph O'Neill - Arlington MA
Charles William Simons - Bedford MA
Robert S. Holdsworth - Arlington MA

Assignee:

W. R. Grace & Co. - Cambridge MA

International Classification:

C07C 2304

US Classification:

260648F

Abstract:

The following newly synthesized bromofluoromethylcyclopropanes have been found to possess utility as general inhalation anesthetics: 1-bromo-1,2-difluoro-2-methylcyclopropane and 1-bromo-1-fluoro-2-methylcyclopropane.

US Patent:

53248643, Jun 28, 1994

Filed:

Dec 18, 1992

Appl. No.:

7/993150

Inventors:

Felix B. Popper - Nashua NH
Gerald J. O'Neill - Arlington MA
Robert J. Bulka - Merrimack NH

Assignee:

Hampshire Chemical Corp. - Lexington MA

International Classification:

C07C 4101

US Classification:

568683

Abstract:

A novel process for synthesizing difluoromethyl methyl ether for use as regrigerants and blowing agents, etc. is hereby disclosed. This process involves (1) feeding chlorodifluoromethane at a rate from about 0. 5 to 5 grams of feed gas per gram of solution per minute through a sodium methoxide in methanol or basic ion exchange slurry in methanol; (2) removing the gaseous product and the unreacted chlorodifluoromethane continuously; and (3) separating difluoromethyl ether from the unreacted chlorodifluoromethane.

US Patent:

39950620, Nov 30, 1976

Filed:

Jul 11, 1975

Appl. No.:

5/595285

Inventors:

Charles A. Billings - Concord MA
Gerald J. O'Neill - Arlington MA
Charles W. Simons - Bedford MA
Robert S. Holdsworth - Arlington MA

Assignee:

W. R. Grace & Co. - Cambridge MA

International Classification:

A61K 31075

US Classification:

424339

Abstract:

The following halocyclopropyl halomethyl ethers have been synthesized and found to possess utility as general inhalation anesthetics: 1-chloro-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-chloro-2-difluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-bromo-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane and 1-bromo-2-difluoromethoxy-1,2,3,3-tetrafluorocyclopropane.

US Patent:

39325296, Jan 13, 1976

Filed:

Dec 26, 1974

Appl. No.:

5/536411

Inventors:

Charles A. Billings - Concord MA
Gerald J. O'Neill - Arlington MA
Charles W. Simons - Bedford MA
Robert S. Holdsworth - Arlington MA

Assignee:

W. R. Grace & Co. - Cambridge MA

International Classification:

C07C 4302

US Classification:

260611R

Abstract:

The following halocyclopropyl halomethyl ethers have been synthesized and found to possess utility as general inhalation anesthetics: 1-chloro-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-chloro-2-difluoromethoxy-1,2,3,3-tetrafluorocyclopropane, 1-bromo-2-chlorofluoromethoxy-1,2,3,3-tetrafluorocyclopropane and 1-bromo-2-difluoromethoxy-1, 2,3,3-tetrafluorocyclopropane.