Gerard L Cote

US Patent:

7704704, Apr 27, 2010

Filed:

Sep 28, 2006

Appl. No.:

11/529280

Inventors:

Bennett L. Ibey - College Station TX, US
Vamsi K. Yadavalli - North Bethesda MD, US
Rebecca M. Rounds - College Station TX, US
Hope T. Beier - College Station TX, US
Gerard L. Cote - College Station TX, US
Michael V. Pishko - State College PA, US

Assignee:

The Texas A&M University System - College Station TX

International Classification:

C12Q 1/54

US Classification:

435 14, 4352871, 4352887

Abstract:

This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the analyte-dependent signal with a detector. A binding protein may reversibly bind an analyte and/or a ligand. A binding protein may have a higher binding affinity for an analyte than for a ligand. A binding protein and a ligand may each include a fluorophore, the absorption and/or emission properties of which may change in an analyte-dependent manner. A binding protein and/or a ligand may be bound to an active or inactive substrate. Some embodiments of systems, devices, and methods may be practiced in vitro, in situ, and/or in vivo. Systems and/or devices of the disclosure may be configured to be wearable.

US Patent:

8088595, Jan 3, 2012

Filed:

Mar 5, 2010

Appl. No.:

12/660884

Inventors:

Bennett L. Ibey - College Station TX, US
Vamsi K. Yadavalli - North Bethesda MD, US
Rebecca M. Rounds - College Station TX, US
Hope T. Beier - College Station TX, US
Gerard L. Cote - College Station TX, US
Michael V. Pishko - State College PA, US

Assignee:

The Texas A&M University System - College Station TX

International Classification:

C12Q 1/54

US Classification:

435 14

Abstract:

This disclosure relates to a method of measuring a glucose concentration metric or a glucose metric in a patient by contacting an implantable glucose-sensing device with a test sample, which may be in the patient, under conditions that permit a sugar-binding molecule and a functionalized polymer or nano-particle ligand present throughout the matrix of a hydrogel to interact in a glucose-dependent manner to produce an optical signal resulting from quenching of a first fluorophore linked to the ligand or sugar-binding molecule and having a fluorescent emission spectrum quenched upon binding or release of glucose. Next the first fluorophore may be excited with light of a certain wavelength. Then at least one wavelength of light in the glucose-dependent optical signal from the fluorophore may be detected with a detector to produce a detected light signal, which may be processed to produce a glucose metric, such as a glucose concentration metric.

US Patent:

20030225321, Dec 4, 2003

Filed:

May 27, 2003

Appl. No.:

10/445648

Inventors:

Gerard Cote - College Station TX, US
Justin Baba - College Station TX, US

International Classification:

A61B005/00

US Classification:

600/318000

Abstract:

There are many inventions described and illustrated herein. In one aspect, the present invention is a system and technique for non-invasively measuring, monitoring, inspecting, characterizing, determining and/or evaluating the blood glucose level in the aqueous humor of the eye of a patient (for example, a diabetic). In one embodiment, the present invention employs a plurality of wavelengths of light (for example, more than three) to measure, monitor, characterize, determine and/or evaluate the blood glucose level or concentration of a patient. The plurality of wavelengths of light may be directed into the aqueous humor of the eye and the reflected light (i.e., the light reflected by the eye) is detected and analyzed to provide information which is representative of the blood glucose level or concentration of the patient.

US Patent:

20090214392, Aug 27, 2009

Filed:

Feb 27, 2008

Appl. No.:

12/038700

Inventors:

Jun Kameoka - College Station TX, US
Gerard L. Cote - College Station TX, US
Hope T. Beier - College Station TX, US
I-Hsien Chou - Diamond Bar CA, US
Melodie Benford - College Station TX, US
Miao Wang - College Station TX, US
Nan Jing - College Station TX, US

Assignee:

THE TEXAS A&M UNIVERSITY SYSTEM - College Station TX

International Classification:

B01L 3/00
B29C 65/00

US Classification:

422102, 156 60

Abstract:

A nano-fluidic trapping device and method of fabrication are disclosed. In one embodiment, a nano-fluidic trapping device for assembling a SERS-active cluster includes a substrate. The nano-fluidic trapping device further includes a SERS-active cluster compartment. The SERS-active cluster is formed in the SERS-active cluster compartment. In addition, the nano-fluidic trapping device includes a reservoir. The reservoir allows introduction of target molecules into the nano-fluidic trapping device. Moreover, the nano-fluidic trapping device includes a microchannel. The microchannel allows the target molecules to be introduced to the SERS-active cluster compartment from the reservoir. The nano-fluidic trapping device also includes a nanochannel. The SERS-active cluster compartment, the reservoir, the microchannel, and the nanochannel are disposed within the substrate.

US Patent:

20180184979, Jul 5, 2018

Filed:

Jan 4, 2017

Appl. No.:

15/398406

Inventors:

- College Station TX, US
Daniel Alge - College Station TX, US
Akhilesh Gaharwar - College Station TX, US
Gerard L. Cote - College Station TX, US

International Classification:

A61B 5/00
A61B 5/021
A61B 5/024
A61B 5/1455

Abstract:

An adhesive interface device includes an interface material having a first surface and a second surface, wherein the first surface is configured to adhere to a tissue, the second surface is configured to adhere to a wearable optical sensor device, and the interface material has a refractive index similar to the tissue when illuminated.

US Patent:

20180021483, Jan 25, 2018

Filed:

Jan 27, 2016

Appl. No.:

15/545811

Inventors:

- College Station TX, US
Gerard L. Cote - College Station TX, US
Alexander A. Abraham - College Station TX, US
Ruochong Fei - College Station TX, US
Andrea K. Locke - College Station TX, US

Assignee:

The Texas A&M University System - College Station TX

International Classification:

A61L 31/04
A61B 5/1473
C08L 33/26
A61B 5/145
A61L 31/10
A61L 31/14

Abstract:

The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane; wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area; wherein the membrane temperature is maintained at substantially the same temperature as the target area; wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.