Grace M Chen

US Patent:

6620986, Sep 16, 2003

Filed:

Nov 16, 2000

Appl. No.:

09/715677

Inventors:

Thomas A. McKeon - Richmond CA
Grace Q. Chen - El Sobrante CA

Assignee:

The United States of America as represented by the Secretary of Agriculture - Washington DC

International Classification:

C12N 1582

US Classification:

800294

Abstract:

The invention is a method of Agrobacterium-mediated transformation of castor. The flower bud of an intact castor plant is wounded and Agrobacterium comprises the transgene is infiltrated into the wound. The flower bud is allowed to get seed, and seed comprising the transgene is grown into a transformed castor plant.

US Patent:

7106432, Sep 12, 2006

Filed:

Dec 9, 2002

Appl. No.:

10/315713

Inventors:

Evan R. Mapoles - San Ramon CA, US
Grace H. Chen - San Jose CA, US
Christopher F. Bevis - Los Gatos CA, US
David W. Shortt - Milpitas CA, US

Assignee:

KLA-Tencor Technologies Corporation - Milpitas CA

International Classification:

G01N 21/00
G01N 21/88
G06K 9/00

US Classification:

3562372, 3562371, 3562374, 3562375, 25055945, 382149

Abstract:

A dark field surface inspection tool of the invention includes an illumination source for directing a light beam onto a work piece. The tool includes a scanning element for enabling selected inspection points on the work piece to be scanned by the light beam. During scanning, the light scattered by each inspection point generates light scattering patterns associated with the surface characteristics of the scanned inspection point. The tool includes a photo detector array having photosensitive elements arranged to receive light from the light scattering pattern, thereby capturing an image of the light scattering pattern for each inspection point. Comparison circuitry is included for comparing light scattering patterns with a reference image to enable the identification of defects at the inspection point. The invention also includes a dark field surface inspection method comprising illuminating an inspection surface with a light beam, capturing images of light scattered from the inspection surface and comparing those images with suitable reference images to detect defects in the inspection surface.

US Patent:

7317527, Jan 8, 2008

Filed:

Nov 29, 2004

Appl. No.:

10/999017

Inventors:

Dragos Maciuca - Castro Valley CA, US
Grace H. Chen - San Jose CA, US
Tao-Yi Fu - Fremont CA, US

Assignee:

KLA-Tencor Technologies Corporation - Milpitas CA

International Classification:

G01J 4/00

US Classification:

356364, 349104

Abstract:

A filter to selectively block light from passing through the filter and to selectively permit light to pass through the filter. The filter includes an array with a plurality of individually addressable filter elements. Each filter element is selectively settable to have a variable transmittance to the light of between substantially zero percent and substantially one hundred percent. In this manner, the filter according to the present invention provides areas that pass only a portion of the light, and thus can block the light using patterns other than just an abrupt on/off filtering. By so doing, the filter is able to dramatically reduce, and in some embodiments eliminate, the light ringing that typically accompanies such on/off filters.

US Patent:

7505619, Mar 17, 2009

Filed:

Dec 20, 2005

Appl. No.:

11/314779

Inventors:

Evan R. Mapoles - San Ramon CA, US
Grace H. Chen - San Jose CA, US
Christopher F. Bevis - Los Gatos CA, US
David W. Shortt - Milpitas CA, US

Assignee:

KLA-Tencor Technologies Corporation - Milpitas CA

International Classification:

G06K 9/00

US Classification:

382149, 25055907, 25055941, 25055945, 348126, 348128, 3562373, 3562398, 356600, 356603, 382144, 382147

Abstract:

A dark field surface inspection tool and system are disclosed herein. The tool includes an illumination source capable of scanning a light beam onto an inspection surface. Light scattered by each inspection point is captured as image data by a photo detector array arranged at a fourier plane. The images captured are adaptively filtered to remove a portion of the bright pixels from the images to generate filtered images. The filtered images are then analyzed to detect defects in the inspection surface. Methods of the invention include using die-to-die comparison to identify bright portions of scattering patterns and generate unique image filters associated with those patterns. The associated images are then filtered to generate filtered images which are then used to detect defects. Also, data models of light scattering behavior can be used to generate filters.

US Patent:

7723112, May 25, 2010

Filed:

Oct 31, 2006

Appl. No.:

11/591019

Inventors:

Michael F. Clarke - Palo Alto CA, US
Tim Hoey - Hillsborough CA, US
Xinhao Wang - Freemont CA, US
Scott Dylla - Mountain View CA, US
Austin Gurney - San Francisco CA, US
Piero Dalerba - Palo Alto CA, US
Mark Prince - Ann Arbor MI, US
Grace Chen - Howell MI, US

Assignee:

The Regents of the University of Michigan - Ann Arbor MI
OncoMed Pharmaceuticals, Inc. - Redwood City CA

International Classification:

G01N 33/53

US Classification:

435971, 435 71, 435325, 435968

Abstract:

The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.

US Patent:

20070049602, Mar 1, 2007

Filed:

May 25, 2006

Appl. No.:

11/420425

Inventors:

Paul Hergenrother - Champaign IL, US
Karson Putt - Urbana IL, US
Grace Chen - Walnut Creek CA, US
Jennifer Pearson - Bloomington IL, US

Assignee:

THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - Urbana IL

International Classification:

A61K 31/495
C07D 241/04

US Classification:

514252120, 544399000

Abstract:

Compounds and related methods for synthesis, and the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3, and particular embodiments are capable of direct activation of procaspase-3 and procaspase-7 to the effector forms of caspase-3 and caspase-7. Procaspase-3 levels can vary among cancer cell types; several types have relatively high levels and can have increased susceptibility to chemotherapy by compounds and methods herein. Therapeutic applications are relevant for a variety of cancer conditions and cell types, e.g. breast, lung, brain, colon, renal, adrenal, melanoma, and others.

US Patent:

20100169990, Jul 1, 2010

Filed:

Dec 31, 2009

Appl. No.:

12/650873

Inventors:

Michael F. Clarke - Menlo Park CA, US
Tim Hoey - Hillsborough CA, US
Xinhao Wang - Freemont CA, US
Scott Dylla - Mountain View CA, US
Austin Gurney - San Francisco CA, US
Piero Dalerba - Palo Alto CA, US
Grace Chen - Howell MI, US
Mark Prince - Ann Arbor MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI

International Classification:

A01K 67/00
C12N 5/00

US Classification:

800 10, 435325

Abstract:

The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid tumor stem cells.

US Patent:

20130054689, Feb 28, 2013

Filed:

Aug 29, 2011

Appl. No.:

13/220315

Inventors:

Jennifer Woldman - Foster Ciry CA, US
Cindy De Guzman - Foster City CA, US
Grace Chen - Foster City CA, US

International Classification:

G06F 15/16

US Classification:

709204

Abstract:

Information regarding a user may be indicative of membership in a group. Such information may be maintained for every user associated with a particular system or title. In instances, redeemable content may be offered exclusively to a group. Requests for such content may therefore be received and evaluated to determine whether the requesting user is a member of the particular group. The determination includes an evaluation of information associated with the requesting user. In some instances, the information associated with the requesting user is a user identifier that is indicative of the group membership, and the user identifier may be included in the request. If the user is indeed determined to be a member of the group, access to the redeemable content is granted. Alternatively, if the user is not determined to be a member of the group, access to the redeemable content is denied.