Graham R Moran

US Patent:

20100227936, Sep 9, 2010

Filed:

Mar 9, 2010

Appl. No.:

12/720381

Inventors:

Graham R. Moran - Whitefish Bay WI, US
Panqing He - Oak Creek WI, US

International Classification:

A61K 31/122
A61P 31/04
A61P 31/10

US Classification:

514676

Abstract:

Methods of inhibiting phagolysosomal fusion in patients infected with a microorganism involve the administration of a 4-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting compound, such as 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) to the patient. A HPPD-inhibiting compound administered in an amount effective to enhance phagolysosomal fusion in the macrophages or neutrophils of the patient reduces or treats the infection. Methods for treating bacterial infections by administering a HPPD-inhibiting compound and reducing the production of pyomelanin or melanin in microorganisms are disclosed.