Granger Martin Sutton

US Patent:

20020182200, Dec 5, 2002

Filed:

May 10, 2002

Appl. No.:

10/141965

Inventors:

Haodong Li - Gaithersburg MD, US
Steven Ruben - Olney MD, US
Granger Sutton - Columbia MD, US

Assignee:

Human Genome Sciences, Inc.

International Classification:

A61K038/43
C07H021/04
C12N009/00
C12P021/02
C12N005/06

US Classification:

424/094100, 435/183000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023200

Abstract:

A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

US Patent:

20030044898, Mar 6, 2003

Filed:

Dec 21, 2001

Appl. No.:

10/024494

Inventors:

Yi Li - Gaithersburg MD, US
Liang Cao - Monmouth Terrace, HK
Jian Ni - Gaithersburg MD, US
Reiner Gentz - Silver Spring MD, US
Carol Bult - Laurel MD, US
Granger Sutton - Columbia MD, US
Craig Rosen - Laytonsville MD, US

Assignee:

Human Genome Sciences, Inc.

International Classification:

C12P021/02
C12N005/06
C07K014/705
C07H021/04

US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

US Patent:

20050118680, Jun 2, 2005

Filed:

Jan 18, 2005

Appl. No.:

11/035998

Inventors:

Haodong Li - Gaithersburg MD, US
Steven Ruben - Brookeville MD, US
Granger Sutton - Columbia MD, US

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K038/19
C07K014/705
C07H021/04

US Classification:

435069100, 435320100, 435325000, 530350000, 536023500, 514012000

Abstract:

A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

US Patent:

58663738, Feb 2, 1999

Filed:

Jun 7, 1995

Appl. No.:

8/479126

Inventors:

Haodong Li - Gaithersburg MD
Steven M. Ruben - Olney MD
Granger G. Sutton - Columbia MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 14475
C07K 1452
C12N 1519
C12N 1563

US Classification:

435 695

Abstract:

A human chemotactic protein polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating for stem cell mobilization, myeloprotection and neuronal protection, to treat tumors, to promote wound healing, to combat parasitic infection and to regulate hematopoiesis. Also disclosed are antagonists against such polypeptides which may be employed to treat rheumatoid arthritis, lung inflammation, allergy, infectious diseases and to prevent inflammation and atherosclerosis. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

US Patent:

61003891, Aug 8, 2000

Filed:

Mar 20, 1998

Appl. No.:

9/044855

Inventors:

Haodong Li - Gaithersburg MD
Steven M. Ruben - Olney MD
Granger Sutton - Columbia MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 120
C12N 510
C12N 1512
C12N 1519

US Classification:

536 235

Abstract:

A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

US Patent:

56187173, Apr 8, 1997

Filed:

Jun 5, 1995

Appl. No.:

8/463975

Inventors:

Ying-Fei Wei - Darnestown MD
Granger G. Sutton - Columbia MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 500
C12N 1500
C12P 2106
C07H 1700

US Classification:

435325

Abstract:

A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.

US Patent:

60905751, Jul 18, 2000

Filed:

Jun 6, 1995

Appl. No.:

8/467947

Inventors:

Yi Li - Gaithersburg MD
Liang Cao - Hong Kong, HK
Jian Ni - Gaithersburg MD
Reiner Gentz - Silver Spring MD
Carol J. Bult - Laurel MD
Granger G. Sutton - Columbia MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 510
C12N 1512
C12N 1562

US Classification:

435 691

Abstract:

Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

US Patent:

59292253, Jul 27, 1999

Filed:

Feb 13, 1998

Appl. No.:

9/023327

Inventors:

Ying-Fei Wei - Darnestown MD
Granger G. Sutton - Columbia MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 1512
C12N 1562
C12N 1570
C12N 1585

US Classification:

536 235

Abstract:

A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.