William Abraham - Miami FL, US Mario Scuri - Miami FL, US Rosanna Forteza - Miami FL, US Jing-Wen Kuo - Wakefield MA, US Paul Mihalko - Fremont CA, US Gregory Conner - Miami FL, US Matthias Salathe - Coral Gables FL, US
International Classification:
A61K031/737 A61K031/728 A61K031/727 A61L009/04
US Classification:
514/054000, 514/056000, 424/045000
Abstract:
A method is disclosed for treating and/or preventing bronchoconstriction induced by neutrophil elastase and tissue kallikrein activity. The method includes administration of aerosolized hyaluronic acid in an amount sufficient to bind to RHAMM (CD168) receptors along the apical surface of the airway epithelium, wherein the hyaluronic acid binds and retains secreted tissue kallikrein, thereby treating and/or preventing bronchoconstriction due to kallikrein activity.