The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
Heterocyclic Ketone And Thioester Compounds And Uses
Gregory S. Hamilton - Catonsville MD Jia-He Li - Cockeysville MD
Assignee:
GPI Nil Holdings, Inc. - Wilmington DE
International Classification:
A61K 31426
US Classification:
514365, 548200, 548201, 548214, 548123, 514372
Abstract:
This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
N-Oxide Of Heterocyclic Ester, Amide, Thioester, Or Ketone Hair Growth Compositions And Uses
Joseph P. Steiner - Finksburg MD Gregory S. Hamilton - Catonsville MD
Assignee:
GPI NIL Holdings, Inc. - Wilmington DE
International Classification:
A61K 3144
US Classification:
514314, 514343, 514423, 514880
Abstract:
This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
Methods Of Using Inhibitors Of Cyclophilin Rotamase Activity To Affect Neurological Activity
Joseph P. Steiner - Finksburg MD Gregory S. Hamilton - Catonsville MD Solomon H. Snyder - Baltimore MD
Assignee:
Guilford Pharmaceuticals Inc. - Baltimore MD Johns Hopkins University School of Medicine - Baltimore MD
International Classification:
A61K 3803
US Classification:
514 11, 514 2, 514 12
Abstract:
This invention relates to the method of using neurotrophic cyclophilin inhibitor compounds having an affinity for cyclophilin-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
Gregory S. Hamilton - Catonsville MD David C. Limburg - Baltimore MD
Assignee:
GPI NIL Holdings, Inc. - Wilmington DE
International Classification:
A61K 31401
US Classification:
514423, 548533, 548537
Abstract:
This invention relates to low molecular weight, small molecule cyclic esters and amides having an affinity for FKBP-type immunophilins, pharmaceutical compositions comprising the same, and methods of using the same to effect a neuronal activity.
N-Oxides Of Heterocyclic Esters, Amides, Thioesters, And Ketones
This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
Joseph P. Steiner - Hampstead MD Solomon Snyder - Baltimore MD Gregory S. Hamilton - Catonsville MD Ted Dawson - Baltimore MD
Assignee:
GPI NIL Holdings, Inc. - Wilmington DE Johns Hopkins University School of Medicine - Baltimore MD
International Classification:
A31K 31445
US Classification:
514317
Abstract:
This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
Pyrrolidine Derivatives And Processes For Preparing Same
Gregory S. Hamilton - Catonsville MD Joseph P. Steiner - Hampstead MD
Assignee:
GPI NIL Holdings, Inc. - Wilmington DE
International Classification:
C07D20716
US Classification:
548533
Abstract:
This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
Name / Title
Company / Classification
Phones & Addresses
Mr. Gregory T. Hamilton President
Pacific Divers Equipment Supply Inc. Blue Fin Watersports Wholesalers & Distributors
99-1451 Koaha Place, Bay #2, Aiea, HI 96701 8084556555, 8084865117