Gregory C Hamilton

US Patent:

6417189, Jul 9, 2002

Filed:

Apr 17, 2000

Appl. No.:

09/551618

Inventors:

Wei Huang - Wildwood MD
Gregory S. Hamilton - Catonsville MD

Assignee:

GPI NIL Holdings, Inc. - Wilmington DE

International Classification:

A61K 31495

US Classification:

51425201, 51425202, 51425203, 51425204, 51425205, 51425206, 514218, 514406, 514407, 540553, 544238, 5483561, 5483641, 5483642, 5483643, 5483644, 5483645, 5483646, 5483647

Abstract:

The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.

US Patent:

6417209, Jul 9, 2002

Filed:

Dec 11, 2000

Appl. No.:

09/733037

Inventors:

Gregory S. Hamilton - Catonsville MD
Jia-He Li - Cockeysville MD

Assignee:

GPI Nil Holdings, Inc. - Wilmington DE

International Classification:

A61K 31426

US Classification:

514365, 548200, 548201, 548214, 548123, 514372

Abstract:

This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.

US Patent:

6462072, Oct 8, 2002

Filed:

Sep 21, 1998

Appl. No.:

09/157566

Inventors:

Gregory S. Hamilton - Catonsville MD
David C. Limburg - Baltimore MD

Assignee:

GPI NIL Holdings, Inc. - Wilmington DE

International Classification:

A61K 31401

US Classification:

514423, 548533, 548537

Abstract:

This invention relates to low molecular weight, small molecule cyclic esters and amides having an affinity for FKBP-type immunophilins, pharmaceutical compositions comprising the same, and methods of using the same to effect a neuronal activity.

US Patent:

6486151, Nov 26, 2002

Filed:

Apr 26, 2001

Appl. No.:

09/842174

Inventors:

Gregory S. Hamilton - Catonsville MD
Joseph P. Steiner - Hampstead MD
Eric S. Burak - Forest Hill MD

Assignee:

GPI NIL Holdings Inc. - Wilmington DE

International Classification:

C07D20310

US Classification:

514212, 514311, 514314, 514315, 514316, 514318, 514423, 540529, 546245, 548530

Abstract:

This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

US Patent:

6500959, Dec 31, 2002

Filed:

Jun 28, 2000

Appl. No.:

09/605475

Inventors:

Gregory S. Hamilton - Catonsville MD
Joseph P. Steiner - Hampstead MD

Assignee:

GPI NIL Holdings, Inc. - Wilmington DE

International Classification:

C07D20716

US Classification:

548533

Abstract:

This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

US Patent:

6509477, Jan 21, 2003

Filed:

Jul 21, 1999

Appl. No.:

09/359351

Inventors:

Gregory S. Hamilton - Catonsville MD
Joseph P. Steiner - Hampstead MD

Assignee:

Guilford Pharmaceuticals Inc. - Baltimore MD

International Classification:

C07D20716

US Classification:

548535, 548537

Abstract:

This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.

US Patent:

6593362, Jul 15, 2003

Filed:

May 21, 2001

Appl. No.:

09/860756

Inventors:

Joseph P. Steiner - Mt. Airy MD
Gregory S. Hamilton - Catonsville MD

Assignee:

Guilford Pharmaceuticals Inc. - Baltimore MD

International Classification:

A61K 3127

US Classification:

514477, 514478, 514479, 514482, 514491, 514589, 514590, 514596

Abstract:

This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promoting hair growth, in treating infections with filarial and helmintic parasites, and in treating and preventing infections with the human immunodeficiency virus.

US Patent:

6677376, Jan 13, 2004

Filed:

Sep 7, 2000

Appl. No.:

09/656898

Inventors:

Gregory S. Hamilton - Catonsville MD
Joseph P. Steiner - Mt. Airy MD
Mark J. Vaal - Baltimore MD
Chi Choi - Towson MD
Ling Wei - Lutherville MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61K 3118

US Classification:

514603, 514 9, 514 11, 514 19, 514604, 514605, 514616, 514619, 514621, 514622, 514626, 514629, 514688, 514689, 514718, 514731, 530317, 564 86

Abstract:

The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.