Gregory A Hughes

US Patent:

20110165632, Jul 7, 2011

Filed:

May 18, 2009

Appl. No.:

12/993341

Inventors:

Louis-Charles Campeau - VAudreuil-Dorian, CA
John Y. Chung - Edison NJ, US
Danny Gauvreau - Saint-Lazare, CA
Melina Girardin-Rondeau - Jonquiere, CA
Gregory Hughes - Scotch Plains NJ, US
Kevin M. Maloney - Piscataway NJ, US
Christophe Mellon - Saint-Redempteur, CA
Jeffrey C. Moore - Westfield NJ, US
Paul O'Shea - Westmount, CA
Stephane Quellet - Saint Lazare, CA

International Classification:

C12P 17/16
C07D 401/14

US Classification:

435118, 544333

Abstract:

The present invention is directed to processes for preparing a pyridyl piperidine compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved.

US Patent:

20120190085, Jul 26, 2012

Filed:

Jun 21, 2010

Appl. No.:

13/378963

Inventors:

Gregory Hughes - Rahway NJ, US
Paul N. Devine - Rahway NJ, US
Fred J. Fleitz - Rahway NJ, US
Brendan T. Grau - Rahway NJ, US
John Limanto - Rahway NJ, US
Christopher Savile - Redwood City CA, US
Emily Mundorff - Poughkeepsie NY, US

Assignee:

CODEXIS, INC. - Redwood City CA

International Classification:

C12P 13/00
C12P 17/10
C12P 17/12

US Classification:

435122, 435128, 435121

Abstract:

The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

US Patent:

20130149751, Jun 13, 2013

Filed:

Aug 8, 2011

Appl. No.:

13/817274

Inventors:

John Limanto - Rahway NJ, US
Gregory L. Beutner - Green Brook NJ, US
Jingjun Yin - Green Brook NJ, US
Artis Klapars - Edison NJ, US
Eric R. Ashley - Fanwood NJ, US
Hallena R. Strotman - Somerset NJ, US
Matthew D. Truppo - Bradley Beach NJ, US
Cheol K. Chung - Westfield NJ, US
Gregory Hughes - Scotch Plains NJ, US
Zhijian Liu - Kendall Park NJ, US
Brendan Grau - Warrington NJ, US
Jacob Janey - New York NY, US

International Classification:

C12P 17/10

US Classification:

435121, 564443

Abstract:

The present invention relates to a process for preparing aminocyclohexyl ether compounds of Formula I: or the pharmaceutically acceptable salts and esters thereof. In particular, the instant invention is directed towards a process for preparing (1R,2R)-2-[(3R)-Hydroxypyrrolidinyl]-1-(3,4-dimethoxyphenethoxy)-cyclohexane as well as various intermediates.

US Patent:

20130164794, Jun 27, 2013

Filed:

Aug 8, 2011

Appl. No.:

13/817295

Inventors:

John Limanto - Metuchen NJ, US
Gregory Beutner - Green Brook NJ, US
Brendan Grau - Warrington PA, US
Jacob Janey - New York NY, US
Artis Klapars - Edison NJ, US
Eric Ashley - Fanwood NJ, US
Hallena R. Strotman - Monmouth Junction NJ, US
Matthew D. Truppo - Ocean Township NJ, US
Gregory Hughes - Scotch Plains NJ, US
Fabien L. Cabirol - Dusseldorf, DE
Anupam Gohel - Singapore, SG
Steven J. Collier - Singapore, SG
Jack Liang - San Mateo CA, US
Marissa Mock - Moorpark CA, US
Emily Mundorff - Poughkeepsie NY, US
Scott Novick - Palo Alto CA, US
Derek Smith - Singapore, SG

Assignee:

CODEXIS, INC. - Redwood City CA

International Classification:

C12N 9/10

US Classification:

435128, 536 232, 435193, 4353201, 4352523, 43525233, 43525235, 43525411, 4352542, 43525421, 43525423, 435348, 435325, 435358, 435365, 435352, 435366, 435419

Abstract:

The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.

US Patent:

45846995, Apr 22, 1986

Filed:

Jan 6, 1984

Appl. No.:

6/568777

Inventors:

Carlo LaFiandra - New Canaan CT
Gregory P. Hughes - Norwalk CT

Assignee:

The Perkin-Elmer Corporation - Norwalk CT

International Classification:

H01J 3510
H01J 3526

US Classification:

378130

Abstract:

The present invention is directed to a rotating anode x-ray source assembly which is particularly adapted for effecting high x-ray emission from a conventional x-ray source for use in replicating VLSI circuits, and comprises a rotatable anode target ring, cooling water flow channels dispose adjacent the target ring for cooling the target ring during operation, an E-beam directed to a spot on the target ring towards the periphery thereof, the cooling water flow channel being constructed and arranged so that on a transverse plane with respect to the axis of rotation all diametrically opposed points on any diameter have the same cooling water density, thereby dynamically balancing the anode under all thermal conditions.