Gregory C Keyes

US Patent:

20220274940, Sep 1, 2022

Filed:

Apr 12, 2022

Appl. No.:

17/718965

Inventors:

- Bethesda MD, US
Gregory Keyes - Timonium MD, US

Assignee:

THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human - Bethesda MD

International Classification:

C07D 303/42
A61P 3/06
A61P 17/00
A61P 25/00
C07C 59/42
G01N 33/92

Abstract:

This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to:wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from:R, R, and Rare independently hydrogen or lower alkyl, Ris lower alkyl, hydroxyl, carboxyl, or amine, Ris hydrogen, lower alkyl, or halide, Ris hydroxyl or substituted thiol, and each Ris independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.

US Patent:

20210139440, May 13, 2021

Filed:

Jul 6, 2018

Appl. No.:

16/622697

Inventors:

- Bethesda MD, US
Gregory Keyes - Baltimore MD, US

Assignee:

THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human servic - Bethesda MD

International Classification:

C07D 303/42
G01N 33/92
C07C 59/42
A61P 25/00
A61P 17/00
A61P 3/06

Abstract:

This disclosure concerns fatty acid derivatives, pharmaceutical compositions comprising the fatty acid derivatives, and methods of using the fatty acid derivatives, for example, to treat inflammation, chronic itch, chronic pain, an autoimmune disorder, atherosclerosis, a skin disorder, arthritis, a neurodegenerative disorder, or a psychiatric disorder in a subject. In some embodiments, the fatty acid derivative is a compound, or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, having a structure according to:wherein X is from 1-16 carbons in length, Z is aliphatic from 1-16 carbons in length, or is not present, Y is selected from:R, R, and Rare independently hydrogen or lower alkyl, Ris lower alkyl, hydroxyl, carboxyl, or amine, Ris hydrogen, lower alkyl, or halide, Ris hydroxyl or substituted thiol, and each Ris independently hydrogen or fluoride or is not present and the adjacent carbons form alkyne.