Gregory P Simon

US Patent:

20130195904, Aug 1, 2013

Filed:

Jan 4, 2011

Appl. No.:

13/520388

Inventors:

J. Thomas August - Baltimore MD, US
Gregory George Simon - Owings Mills MD, US
Tin Wee Tan - Singapore, SG
Asif Mohammad Khan - Singapore, SG
Hu Yongli - Singapore, SG

Assignee:

NATIONAL UNIVERSITY OF SINGAPORE - Singapore
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61K 39/21

US Classification:

4241861, 530300, 536 2372, 4353201, 435325, 435 691, 435 5

Abstract:

We identified regions of the HIV-1 proteome with high conservation, and low variant incidence. Such highly conserved sequences have direct relevance to the development of new-generation vaccines and diagnostic applications. The immune relevance of these sequences was assessed by their correlation to previously reported human T-cell epitopes and to recently identified human HIV-1 T-cell epitopes (identified using HLA transgenic mice). We identified (a) sequences specific to HIV-1 with no shared identity to other viruses and organisms, and (b) sequences that are specific to primate lentivirus group, with multiclade HIV-1 conservation.