Gregory Slobodkin

US Patent:

8057821, Nov 15, 2011

Filed:

Nov 3, 2004

Appl. No.:

10/981135

Inventors:

Gregory Slobodkin - Huntsville AL, US
Majed Matar - Madison AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US

Assignee:

EGEN, Inc. - Huntsville AL

International Classification:

A61K 48/00

US Classification:

424486, 528310, 528332

Abstract:

A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

US Patent:

8445017, May 21, 2013

Filed:

Sep 20, 2011

Appl. No.:

13/237168

Inventors:

Gregory Slobodkin - Huntsville AL, US
Majed Matar - Madison AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US

Assignee:

Egen, Inc. - Huntsville AL

International Classification:

A61K 48/00

US Classification:

424486, 528310, 528332, 424 852

Abstract:

A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

US Patent:

8460696, Jun 11, 2013

Filed:

Mar 19, 2010

Appl. No.:

12/727987

Inventors:

Gregory Slobodkin - Huntsville AL, US
Richard Congo - Huntsville AL, US
Majed Matar - Madison AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US
Brian Jeffery Sparks - Huntsville AL, US

Assignee:

Egen, Inc. - Huntsville AL

International Classification:

A61F 2/00

US Classification:

424426, 554 58, 544 44, 544258

Abstract:

Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.

US Patent:

20100004313, Jan 7, 2010

Filed:

Feb 27, 2009

Appl. No.:

12/395240

Inventors:

Gregory Slobodkin - Huntsville AL, US
Majed Matar - Madison AL, US
Brian Jeffery Sparks - Huntsville AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US

International Classification:

A61K 48/00
C08G 65/00

US Classification:

514 44 A, 525409, 514 44 R

Abstract:

Nucleotide delivery polymers, compositions, and associated methods for the enhancement of gene delivery and expression in solid tissues are provided. In one aspect, for example, a nucleotide delivery polymer may include a poloxamer backbone having a metal chelator covalently coupled to at least one terminal end of the poloxamer backbone. In another aspect, the nucleotide expression polymer has a metal chelator coupled to at least two terminal ends of the poloxamer backbone.

US Patent:

20100004315, Jan 7, 2010

Filed:

Mar 16, 2009

Appl. No.:

12/404989

Inventors:

Gregory Slobodkin - Huntsville AL, US
Majed Matar - Madison AL, US
Brian Jeffery Sparks - Huntsville AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US

International Classification:

C08G 73/04
A61K 31/7105
A61K 31/7052

US Classification:

514 44 A, 525417, 525 541, 514 44 R, 514 43

Abstract:

Disclosed is a cross-linked branched poly(alkylenimine) and compositions thereof and nucleotide molecules. Also disclosed are methods for preparing the cross-linked branched poly(alkylenimine).

US Patent:

20130251809, Sep 26, 2013

Filed:

Mar 8, 2013

Appl. No.:

13/791102

Inventors:

Gregory Slobodkin - Huntsville AL, US
Richard Congo - Huntsville AL, US
Majed Matar - Madison AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US
Brian Jeffery Sparks - Huntsville AL, US

Assignee:

Egen, Inc. - Huntsville AL

International Classification:

A61K 47/48
A61K 47/16

US Classification:

424490, 564159, 514788, 564153, 544258, 536 245, 536 231, 514 44 R, 514 44 A, 514249, 424400, 435375

Abstract:

Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.

US Patent:

20140050775, Feb 20, 2014

Filed:

Mar 8, 2013

Appl. No.:

13/790980

Inventors:

Gregory Slobodkin - Huntsville AL, US
Richard Congo - Huntsville AL, US
Majed Matar - Madison AL, US
Jason Fewell - Madison AL, US
Khursheed Anwer - Madison AL, US
Brian Jeffery Sparks - Huntsville AL, US

Assignee:

Egen, Inc. - Huntsville AL

International Classification:

C07C 233/38
C07H 15/10
A61K 9/127
C07K 7/64
A61K 31/713
C07D 475/04
C07K 7/23

US Classification:

424450, 554 58, 544258, 554 57, 536 179, 530313, 530328, 514 44 A, 514 44 R, 514616, 514249, 514 25, 514 101, 514 211, 424400

Abstract:

Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.

US Patent:

6804907, Oct 19, 2004

Filed:

Aug 26, 2002

Appl. No.:

10/226741

Inventors:

Gregory Slobodkin - Burlington MA 01803

International Classification:

F41C 2300

US Classification:

42 7102, 42 94, 42 7101, 42 85, 42 90, 42 72, 42 74

Abstract:

An anatomical hand grip for a firearm is disclosed providing a trigger finger support protrusion for the positioning of the mid-portion of the distal phalanx of the index trigger finger directly on the trigger.