Gregory Weiss

US Patent:

8513001, Aug 20, 2013

Filed:

Mar 9, 2007

Appl. No.:

12/282143

Inventors:

Gregory A. Weiss - Irvine CA, US
Reginald M. Penner - Newport Beach CA, US
Phillip Y. Tam - El Monte CA, US
Li-Mei Yang - Fountain Valley CA, US
Tyler Brigham - Irvine CA, US

Assignee:

The Regents of The University of California - Oakland CA

International Classification:

C12M 1/34

US Classification:

4352871, 4352831, 4352872, 435 5, 422 50, 422 98, 436501

Abstract:

A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate.

US Patent:

8525237, Sep 3, 2013

Filed:

Oct 3, 2011

Appl. No.:

13/251923

Inventors:

Gregory A. Weiss - Irvine CA, US
Reginald M. Penner - Newport Beach CA, US
Jessica A. Arter - Laguna Beach CA, US
David K. Taggart - Mission Viejo CA, US
Keith C. Donavan - Irvine CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01R 27/08

US Classification:

257253, 257E214, 257E29242, 422 8202, 438 49, 977762

Abstract:

Grafting M13 bacteriophage into an array of poly(3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition (LPNE). The resultant arrays of rgps-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.

US Patent:

20120165226, Jun 28, 2012

Filed:

Jul 28, 2008

Appl. No.:

12/181222

Inventors:

Sachdev S. SIDHU - Toronto, CA
Gregory A. Weiss - Irvine CA, US
James A. Wells - Burlingame CA, US

International Classification:

C40B 40/02
C12N 5/10
C07K 19/00
C12N 15/63
C40B 30/04
C40B 50/00
C12N 7/01
C12N 1/21

US Classification:

506 14, 4352351, 435325, 435419, 4352523, 43525231, 43525233, 43525234, 4353201, 506 9, 506 23, 530350

Abstract:

The transformation yield of electroporation is increased by using higher DNA concentrations and DNA affinity purification. Fusion proteins of a viral coat protein variant and a heterologous polypeptide are useful in phage display systems.

US Patent:

20120183478, Jul 19, 2012

Filed:

May 19, 2010

Appl. No.:

13/321011

Inventors:

Gregory A. Weiss - Irvine CA, US
Jessica Arter - Irvine CA, US
Juan E. Diaz - San Francisco CA, US

International Classification:

A61K 49/14
C07K 7/08
C07K 4/00
G01N 33/566
A61K 49/00
A61K 49/22
A61K 49/04
C07K 7/06
C12N 9/96

US Classification:

424 934, 530328, 530327, 530300, 435188, 424 91, 424 95, 424 94, 435 71, 436501

Abstract:

PSMA ligands, compositions, and methods therefore are disclosed where the ligand is a peptide having the sequence XXCVEVXQNSCXXwhere X-Xare independently a natural or non-natural amino acid or a peptide having the sequence CALCEFLG [SEQ ID NO: 1]. Especially preferred aspects include diagnostic reagents for detection and/or quantification of PSMA in a sample, therapeutic reagents, and diagnostic imaging reagents.

US Patent:

20180051316, Feb 22, 2018

Filed:

Dec 17, 2015

Appl. No.:

15/537072

Inventors:

- Oakland CA, US
Gregory A. Weiss - Irvine CA, US
Yongki Choi - Irvine CA, US
Tivoli Olsen - Irvine CA, US

International Classification:

C12Q 1/48
G01N 27/414

Abstract:

The invention provides methods and compositions for detecting a change in a nucleic acid polymerase conformation involving contacting a nucleic acid polymerase non-covalently attached to a single walled carbon nanotube (SWNT) with a first nucleotide or first nucleotide analog and a template and detecting the conformationally changed nucleic acid polymerase by measuring a first electrical conductance change in the SWNT between the nucleic acid polymerase and the conformationally changed nucleic acid polymerase. The method is useful for sequencing of polynucleotides.