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A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics.
Sachdev Sidhu - San Francisco CA, US Gregory Weiss - Irvine CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C40B 30/06 C40B 40/08 C40B 40/10
US Classification:
435006000, 435007100
Abstract:
A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics.
Electronic Device For Monitoring Single Molecule Dynamics
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA, US Gregory A. Weiss - Irvine CA, US Yongki Choi - Irvine CA, US Issa S. Moody - San Diego CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
A single molecule sensing device includes a first electrode, a second electrode and a single-walled carbon nanotube (SWNT) connected to the first and second electrodes. At least one linker molecule having first and second functional groups is functionalized with a sidewall of the SWNT, the at least one linker molecule having the first functional group non-covalently functionalized with a sidewall of the single-walled carbon nanotube. A single sensitizing molecule having at least one functional group is functionalized with the second functional group of the at least one linker molecule.
- Oakland CA, US - Newport Beach CA, US Apurva BHASIN - Oakland CA, US Gregory A. WEISS - Irvine CA, US Phillip TAM - Newport Beach CA, US Jeffrey Scott BRIGGS - Newport Beach CA, US Aisha ATTAR - Irvine CA, US Shae Victoria PATTERSON - Newport Beach CA, US
International Classification:
G01N 27/414 C12N 7/00 G01N 27/327 G01N 27/02
Abstract:
Provided herein are, inter alia, biosensors and electrochemical cells comprising electronically conductive polymers and viral particles; diagnostic kits; and methods of detecting compounds in samples.
Like many researchers, Gregory Weiss, a member of the research team, has struggled to efficiently produce or recycle molecular proteins that have a wide range of applications but frequently mis-fold into structurally incorrect shapes when they are formed, rendering them useless.
A team of researchers including Gregory Weiss, UCIs professor of chemistry and molecular biology and biochemistry, began the experiment by cooking an egg at 195 degrees for 20 minutes. They then added a chemical that turned the solid back to a liquid. To complete the process, the researches used an
Date: Jan 29, 2015
Category: Sci/Tech
Source: Google
Want To Un-Boil An Egg? Science Has Figured Out How
as soon as they are formed and can't really be used in the lab at all. According to lead researcher Gregory Weiss,"The real problem is that there are lots of cases of gummy proteins that you spend way too much time scraping off your test tubes, and you want some means of recovering that material."
"We start with egg whites boiled for 20 minutes at 90 degrees Celsius and return a key protein in the egg to working order," chemistry professor Gregory Weiss explained. "It's not so much that we're interested in processing the eggs; that's just demonstrating how powerful this process is. The real p
Date: Jan 29, 2015
Category: Sci/Tech
Source: Google
Researchers Found A Technique To UNBOIL An Egg, And Say It Could ...
Yes, we have discovered how to unboil a hen egg, Dr. Gregory Weiss, a professor of chemistry at the University of California, Irvine and one of the researchers, said. In our study, we depict a device for pulling apart tangled proteins and permitting them to refold. We initiate with egg whites b
Date: Jan 28, 2015
Source: Google
Researchers figure out how to “unboil” egg whites, and it could make cancer ...
vice for pulling apart tangled proteins and allowing them to refold. We start with egg whites boiled for 20 minutes at 90 degrees Celsius and return a key protein in the egg to working order, Gregory Weiss, UCI professor of chemistry and molecular biology & biochemistry said in the release.
Date: Jan 28, 2015
Category: Sci/Tech
Source: Google
Scientists finally unboil an egg. What was the point?
, Irvine, scientists have successfully discovered a way to return a boiled egg to its unboiled state. Gregory Weiss, UCI professor of chemistry and molecular biology and biochemistry, said the process highlights the amazing ability to unfold tangled proteins and return them to their original shapes.
Date: Jan 28, 2015
Category: Sci/Tech
Source: Google
University of California Irvine, Australian chemists figure out how to unboil eggs ...
"The problem is when we tried to produce cancer-associated proteins... often times the proteins come out as a jumbled mess," Gregory Weiss, UC Irvine professor of chemistry, says. "It kind of looks like boiled eggs... When that happens, we sigh deeply."