Guang X Chen

US Patent:

20030103945, Jun 5, 2003

Filed:

Feb 8, 2002

Appl. No.:

10/072830

Inventors:

Dong Chen - Newton MA, US
Xizhong Huang - Framingham MA, US
Guang Chen - Potomac MD, US
Husseini Manji - Rockville MD, US

International Classification:

A61K033/00
A61K038/18
C12N005/08

US Classification:

424/093700, 424/722000, 514/012000, 435/368000

Abstract:

Agents which modulate a bcl family member to control axonal growth and regeneration are described. These bcl modulating agents promote axonal growth and regeneration in the neural cells of a subject. Compositions for promoting axonal cell growth in a subject also are described. The compositions of the present invention include an effective amount of an agent which modulates a bcl family member and in a pharmaceutically acceptable carrier. Other described aspects include packaged drugs for treating a state characterized by diminished potential for axonal growth. The packaged compounds and agents also include instructions for using the agent to promote axonal growth in a subject. An exemplary agent is lithium or a salt thereof.

US Patent:

20210208169, Jul 8, 2021

Filed:

Mar 22, 2021

Appl. No.:

17/209082

Inventors:

- Cambridge MA, US
Guang Chen - Newton MA, US
Qiang Liu - Cambridge MA, US
Brian Wee - Somerville MA, US

International Classification:

G01N 35/00

Abstract:

Embodiments of automated assay processing systems and methods are disclosed. In an example, an assay automation system includes an assay processing tube, a magnet, and a controller. The assay processing tube has a right arm and a left arm, the right arm having an opening for receiving reagent transferred from a reagent tube being held in one of the tube-holding arms of the reagent tube holder, the assay processing tube being driven to rotate. The magnet is driven to move vertically. The controller is configured to control coordinated movements of the assay processing tube and the magnet to perform an assay processing sequence.

US Patent:

20200110101, Apr 9, 2020

Filed:

Oct 2, 2019

Appl. No.:

16/591545

Inventors:

- Cambridge MA, US
Guang Chen - Newton MA, US
Qiang Liu - Cambridge MA, US

International Classification:

G01N 35/00

Abstract:

Embodiments of systems and methods for automated sample handling are disclosed. In an example, a system for automated sample handling includes reaction wells, a magnet, a magnetic manipulator, and a punch. The reaction wells are configured to each hold a reagent and collectively move horizontally. A first reaction well holds magnetic beads, and a second reaction well is partitioned by a seal. The magnet is configured to move vertically and capture the magnetic beads on a bottom surface of the first reaction well when moving to an upper position beneath the first reaction well. The magnetic manipulator is configured to manipulate the magnetic beads and includes a magnetic rod configured to move vertically to be above or in the first reaction well and a sheath below the magnetic rod and configured to move vertically and receive the magnetic rod. The punch is configured to move vertically and break the seal of the second reaction well when moving to a lower position in the second reaction well.