Guillermo M Vasquez

US Patent:

7569686, Aug 4, 2009

Filed:

May 10, 2007

Appl. No.:

11/747042

Inventors:

Balkrishen Bhat - Carlsbad CA, US
Jie Xia - Carlsbad CA, US
Punit P. Seth - San Marcos CA, US
Guillermo Vasquez - Oceanside CA, US
Michael T. Migawa - Carlsbad CA, US
Charles Allerson - San Diego CA, US
Thazha P. Prakash - Carlsbad CA, US
Eric E. Swayze - Carlsbad CA, US

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

C07H 21/00

US Classification:

536 253, 536 181, 536 185, 536 186, 536 221

Abstract:

The present invention provides compounds and methods of using them for preparing bicyclic nucleosides. The bicyclic nucleosides are useful for preparing chemically modified oligomeric compounds. Oligomeric compounds comprising these bicyclic nucleosides have enhanced properties such as increased nuclease resistance.

US Patent:

20190209694, Jul 11, 2019

Filed:

Sep 7, 2018

Appl. No.:

16/125197

Inventors:

- Carlsbad CA, US
Jinghua Yu - San Marcos CA, US
W. Brad Wan - Fallbrook CA, US
Sayten P. Patel - Mundelein IL, US
Guillermo Vasquez - Oceanside CA, US
Garth A. Kinberger - San Diego CA, US
Thazha P. Prakash - Carlsbad CA, US
Punit P. Seth - Carlsbad CA, US
Eric E. Swayze - Encinitas CA, US

Assignee:

Ionis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 47/54
C07H 21/00
C07H 15/04
C07H 15/18

Abstract:

Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

US Patent:

20170043025, Feb 16, 2017

Filed:

May 1, 2015

Appl. No.:

15/307319

Inventors:

- Carlsbad CA, US
Jinghua Yu - San Marcos CA, US
W. Brad Wan - Fallbrook CA, US
Satyen P. Patel - Mundelein IL, US
Guillermo Vasquez - Oceanside CA, US
Garth A. Kinberger - San Diego CA, US
Thazha P. Prakash - Carlsbad CA, US
Punit P. Seth - Carlsbad CA, US
Eric E. Swayze - Encinitas CA, US

Assignee:

Ionis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 47/48
C07H 15/04
C07H 15/18

Abstract:

Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.