Guizhi Li from 1153 Washington Valley Rd, Basking Ridge, NJ 07920, age 57

Us Patents

Self-Assembled Biodegradable Polymersomes
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US Patent:

20090214419, Aug 27, 2009
Filed:

Sep 28, 2006
Appl. No.:

12/088343
Inventors:

Michael J. Therien - Philadelphia PA, US
Daniel A. Hammer - Villanova PA, US
Paiman Peter Ghoroghchian - Downingtown PA, US
Guizhi Li - Rochester NY, US
Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:

A61K 51/12
C08G 63/08
A61K 38/02
A61K 31/70
A61K 33/00
A61K 31/00
A61K 49/18
A61K 49/04
B05D 3/00
US Classification:

424 121, 525450, 514 2, 514 23, 424600, 514 1, 424 93, 424 94, 427 214
Abstract:

The invention concerns a block copolymer of polyethylene oxide and polycaprolactone, the polyethylene oxide having a number average molecular weight from about 2.0 to about 3.8 kD, the block copolymer having a fraction of polyethylene oxide of from about 11.8 to 18.8 percent by weight. The invention also concerns polymersomes made from such copolymers and to methods of making the polymersomes.

Transdermal Delivery Of Optical, Spect, Multimodal, Drug Or Biological Cargo Laden Nanoparticle(S) In Small Animals Or Humans
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US Patent:

20090280064, Nov 12, 2009
Filed:

Sep 2, 2008
Appl. No.:

12/202681
Inventors:

Rao Papineni - Brandord CT, US
Douglas Lincoln Vizard - Durham CT, US
William E. McLaughlin - Guilford CT, US
John William Harder - Rochester NY, US
David L. Patton - Lebannon PA, US
Guizhi Li - Rochester NY, US
International Classification:

A61K 49/06
A61K 49/00
A61K 49/04
US Classification:

424 93, 424 91, 424 94, 424 96
Abstract:

A method and a device are disclosed for transdermal delivery to an animal or human of biological cargo-laden nanoparticles. The particles may include multimodal optical molecular imaging probes. The particles may be delivered by providing them in a form that can be absorbed through the skin and applying them to the skin of an animal or human. The application may be accomplished using biological cargo-laden nanoparticles in a device attachable to the skin. The device may be attached directly to the skin by a device containing a vasodilating agent or agents, or micro needles, or multi-layer time release material. The biological cargo-laden nanoparticles may comprise drugs, vaccines, bio-pharmaceuticals, imaging contrast agents, multimodal imaging contrast agents, biomolecules, or anti-infectives. The device may include a first plurality of different types of biological cargo-laden nanoparticles located in a corresponding second plurality of separate time release layers.

Transmucosal Delivery Of Optical, Spect, Multimodal,Drug Or Biological Cargo Laden Nanoparticle(S) In Small Animals Or Humans
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US Patent:

20090180964, Jul 16, 2009
Filed:

Dec 22, 2008
Appl. No.:

12/340993
Inventors:

Rao Papineni - Branford CT, US
Guizhi Li - Rochester NY, US
John William Harder - Rochester NY, US
Douglas Lincoln Vizard - Durham CT, US
William E. McLaughlin - Guilford CT, US
David L. Patton - Lebannon PA, US
International Classification:

A61K 49/04
A61K 49/00
A61K 49/06
US Classification:

424 93, 424 91, 424 94, 424 96
Abstract:

A method is taught that provides for transmucosal delivery of a biological cargo and optical molecular imaging probes to a subject animal or human. At least one biological cargo-laden nanoparticle imaging probe is provided in a form that will be absorbed via mucosal tissue. The biological cargo-laden nanoparticle imaging probe is delivered to the mucosal tissue of the animal or human. The method further may include steps of providing a support member adapted to receive the subject in an immobilized state; positioning the subject on the support member; and after the delivering of the imaging probe, imaging the immobilized subject using a multimodal imaging system.