Guofu M Li

US Patent:

7939327, May 10, 2011

Filed:

Feb 28, 2008

Appl. No.:

12/072871

Inventors:

Jeffrey Miller - Richmond CA, US
Guofu Li - Johnston IA, US
Carl Pabo - Mill Valley CA, US
Trevor Collingwood - Novato CA, US

Assignee:

Sangamo Biosciences, Inc. - Richmond CA

International Classification:

C12N 15/82
C12N 5/14

US Classification:

435468, 435419

Abstract:

Disclosed herein are compositions and methods that regulate expression of two or more endogenous genes.

US Patent:

7947873, May 24, 2011

Filed:

Apr 17, 2003

Appl. No.:

10/418552

Inventors:

Guofu Li - Johnston IA, US
Qiang Liu - Foster City CA, US
Andrew Jamieson - San Francisco CA, US
Edward Rebar - El Cerrito CA, US
Mylavarapu Venkatramesh - Ballwin MO, US

Assignee:

Sangamo Biosciences, Inc. - Richmond CA

International Classification:

A01H 1/00
C12N 15/82
C12N 15/87

US Classification:

800288, 800278, 435 697, 4353201, 435 691, 530300

Abstract:

Disclosed herein are zinc finger proteins that bind to target sites in a plant gamma-tocopherol methyl transferase (GMT) gene; compositions comprising these GMT-targeted zinc finger proteins and methods of making and using such zinc finger proteins. Also disclosed are methods for modulating the alpha-tocopherol content in various plant organs, particularly seeds, in transgenic plants.

US Patent:

7262054, Aug 28, 2007

Filed:

Jan 22, 2002

Appl. No.:

10/470180

Inventors:

Andrew Jamieson - San Francisco CA, US
Guofu Li - Johnston IA, US

Assignee:

Sangamo Biosciences, Inc. - Richmond VA

International Classification:

C12N 5/04

US Classification:

435410, 435419

Abstract:

Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring plant zinc finger proteins, have a binding specificity that is determined by tandem arrays of modular zinc finger binding units.

US Patent:

7361635, Apr 22, 2008

Filed:

Aug 29, 2003

Appl. No.:

10/651761

Inventors:

Jeffrey Miller - Richmond CA, US
Guofu Li - Johnston IA, US
Carl Pabo - Mill Valley CA, US
Trevor Collingwood - Novato CA, US

Assignee:

Sangamo Biosciences, Inc. - Richmond CA

International Classification:

A61K 38/00
C12P 21/06
C07K 14/00
C07H 21/04
G01N 33/53

US Classification:

514 2, 435 691, 435 71, 530350, 536 231

Abstract:

Disclosed herein are compositions and methods that regulate expression of two or more endogenous genes.

US Patent:

20040091990, May 13, 2004

Filed:

Aug 27, 2003

Appl. No.:

10/650454

Inventors:

Guofu Li - Johnston IA, US
Qiang Liu - Foster City CA, US
Andrew Jamieson - San Francisco CA, US
Edward Rebar - El Cerrito CA, US

International Classification:

C07H021/04
C12N009/10
C12N015/82

US Classification:

435/193000, 435/468000, 536/023200

Abstract:

Disclosed herein are zinc finger proteins that bind to target sites in a plant gamma-tocopherol methyl transferase (GMT) gene; compositions comprising these GMT-targeted zinc finger proteins and methods of making and using such zinc finger proteins.

US Patent:

20100169998, Jul 1, 2010

Filed:

Dec 28, 2009

Appl. No.:

12/647572

Inventors:

Guofu Li - Johnston IA, US
Junli Ji - Des Moines IA, US

Assignee:

PIONEER HI-BRED INTERNATIONAL INC. - Johnston IA

International Classification:

A01H 1/00

US Classification:

800275

Abstract:

The invention provides a rapid and efficient method and assay for monitoring yield enhancement in a plant using a measure of silk number. The plant is transformed with a prospective gene associated with yield enhancement. The transformed plant is grown along with non-transformed control plants until silk growth is apparent. The change in the number of silks in the transformed plant correlated to the change in yield for the plant. Therefore, changes in yield enhancement can be estimated in the transformed plant prior to harvest of mature plant tissues.

US Patent:

20100269228, Oct 21, 2010

Filed:

Apr 1, 2010

Appl. No.:

12/752212

Inventors:

Guofu Li - Johnston IA, US

Assignee:

PIONEER HI-BRED INTERNATIONAL, INC. - Johnston IA

International Classification:

A01H 5/00
C12N 15/82
C07H 21/00
C12N 15/74

US Classification:

800290, 800298, 8003201, 8003202, 8003203, 800320, 800278, 536 231, 4353201

Abstract:

Compositions and methods for modulating plant development and for increasing yield in a plant are provided. The compositions include a PC4 sequence. Compositions of the invention comprise amino acid sequences and nucleotide sequences selected from SEQ ID NOS: 1 and 2 as well as variants and fragments thereof. Nucleotide sequences encoding the PC4 molecule are provided in DNA constructs for expression in a plant of interest are provided for modulating the level of a PC4 sequence in a plant or a plant part are provided. The methods comprise introducing into a plant or plant part a heterologous polynucleotide comprising a PC4 sequence of the invention. The level of the PC4 polypeptide can be increased or decreased. Such method can be used to increase the yield in plants; in one embodiment, the method is used to increase grain yield in cereals.

US Patent:

20110047650, Feb 24, 2011

Filed:

Aug 19, 2010

Appl. No.:

12/859310

Inventors:

Guofu Li - Johnston IA, US

Assignee:

PIONEER HI-BRED INTERNATIONAL, INC. - Johnston IA

International Classification:

A01H 5/00
C12N 15/82
C12N 15/54
C12N 15/63
C12N 9/12

US Classification:

800290, 800298, 8003201, 8003203, 800320, 8003202, 800278, 536 232, 4353201, 435194

Abstract:

Compositions and methods for modulating plant development and for increasing yield in a plant are provided. The compositions include a ZMPKL1 sequence. Compositions of the invention comprise amino acid sequences and nucleotide sequences selected from SEQ ID NOS: 2 and 43 as well as variants and fragments thereof. Nucleotide sequences encoding the ZMPKL1 molecule are provided in DNA constructs for expression in a plant of interest are provided for modulating the level of a ZMPKL1 sequence in a plant or a plant part are provided. The methods comprise introducing into a plant or plant part a heterologous polynucleotide comprising a ZMPKL1 sequence of the invention. The level of the ZMPKL1 polypeptide can be increased or decreased. Such method can be used to increase the yield in plants; in one embodiment, the method is used to increase grain yield in cereals.