Ha Minh Nguyen

US Patent:

20200208090, Jul 2, 2020

Filed:

Feb 28, 2020

Appl. No.:

16/804924

Inventors:

- Baltimore MD, US
Guoli Ming - Clarksville MD, US
Mingxi Max Song - Clarksville MD, US
Christopher Hadiono - Armonk NY, US
William Jeang - Houston TX, US
Ha Nam Nguyen - Baltimore MD, US
Xuyu Qian - Baltimore MD, US

International Classification:

C12M 1/32
B01F 7/18
B01F 13/10
C12M 1/34
C12M 1/06
B01F 15/00
B01F 7/00
C12M 1/36
C12M 3/00
C12M 1/12
C12M 3/04
C12N 5/0793
G01N 33/50

Abstract:

The present invention is based in part on the discovery of significant improvements to cell culture systems and methods of generating organoids. The system of the invention provides a novel spinning bioreactor platform for higher-throughput 3D culturing of stem cells (e.g., human induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)). The system can be widely used as a standard platform to generate stem cell-derived human organoids for any tissue and for high-throughput drug screenings, toxicity testing, and modeling normal human organ development and diseases.

US Patent:

20180334646, Nov 22, 2018

Filed:

Nov 11, 2016

Appl. No.:

15/775368

Inventors:

- Baltimore MD, US
Guoli Ming - Clarksville MD, US
Mingxi Max Song - Clarksville MD, US
Christopher Hadiono - Armonk NY, US
William Jeang - Houston TX, US
Ha Nam Nguyen - Baltimore MD, US
Xuyu Qian - Baltimore MD, US

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

C12M 1/32
C12M 3/04
C12M 1/12
G01N 33/50
C12M 3/00
C12N 5/0793

Abstract:

The present invention is based in part on the discovery of significant improvements to cell culture systems and methods of generating organoids. The system of the invention provides a novel spinning bioreactor platform for higher-throughput 3D culturing of stem cells (e.g. human induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)). The system can be widely used as a standard platform to generate stem cell-derived human organoids for any tissue and for high-throughput drug screenings, toxicity testing, and modeling normal human organ development and diseases.