Hao Chen

US Patent:

8415385, Apr 9, 2013

Filed:

Jul 12, 2011

Appl. No.:

13/180996

Inventors:

Hao Chen - Columbia MD, US
Ming Liu - Rockville MD, US
Qi Su - Columbia MD, US
Manish Raisinghani - Jamesburg NJ, US

International Classification:

A61K 31/4245
C07D 271/04

US Classification:

514364, 548125

Abstract:

Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

US Patent:

20020187514, Dec 12, 2002

Filed:

Mar 26, 2002

Appl. No.:

10/105407

Inventors:

Hao Chen - Columbia MD, US
David Manyak - Ellicott City MD, US

International Classification:

G01N033/53
G01N033/542
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/007100, 435/007900, 702/019000

Abstract:

The invention provides methods determining a set of one or more molecular targets for developing a treatment for abuse of, or addiction to, a substance. The methods involve determining a biological activity profile by determining a set of molecular targets whose activity is effected by the abused or addictive substance. The biological activity profile may then be used in other methods of the invention to identify at least one chemical compound to treat abuse or addiction. The chemical compounds interact with the molecular targets in a manner substantially the same as the abused or addictive substance. The invention also provides methods for treating substance abuse wherein chemical compounds identified by the methods of the invention are administered in effective amounts to patients in need thereof. A computer system for implementing the methods of the invention is also provided.

US Patent:

20040117125, Jun 17, 2004

Filed:

Sep 25, 2003

Appl. No.:

10/669705

Inventors:

Hao Chen - Columbia MD, US
David Manyak - Ellicott City MD, US
Peter Carlson - Chevy Chase MD, US
Fong Wang - Potomac MD, US
Ming Liu - Rockville MD, US

International Classification:

G06F019/00
G01N033/48
G01N033/50
G01N031/00

US Classification:

702/019000, 702/022000

Abstract:

Methods and systems for drug discovery and development are disclosed. Methods and system consistent with the present invention discover drugs. One or more databases comprising chemical and biological interaction data and one or more computer-based data analysis programs may be used to identify compounds that have desired activity at two or more molecular targets that are associated with a disease state for which the drug discovery and development are directed. In addition, one or more databases comprising chemical and biological interaction data and one or more computer-based data analysis programs may be used to identify compounds that (a) have desired activity at one or more molecular targets that are associated with a disease state for which the drug discovery and development are directed and (b) do not have activity or have substantially reduced activity that is undesired at one or more molecular targets that are associated with possible side effects, toxicity, adverse ADME properties, or other properties not intended to be manifested by compounds being developed to treat the disease state associated with the drug discovery.

US Patent:

20080114080, May 15, 2008

Filed:

Jun 1, 2007

Appl. No.:

11/757292

Inventors:

Hao Chen - Columbia MD, US

International Classification:

C12Q 1/68
A61K 47/00

US Classification:

514789000, 435006000

Abstract:

A screening assay to identify agents which act synergistically to compensate for defective chloride ion transport in cells harboring a mutation in the CFTR in provided.

US Patent:

20080319030, Dec 25, 2008

Filed:

Mar 14, 2008

Appl. No.:

12/048334

Inventors:

Hao Chen - Columbia MD, US
Ming Liu - Rockville MD, US
Qi Su - Columbia MD, US
Manish Raisinghani - Jamesburg NJ, US

International Classification:

A61K 31/4245
C07D 271/04
A61P 25/16
A61P 25/18
A61P 25/24

US Classification:

514364, 548125

Abstract:

Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

US Patent:

20090215839, Aug 27, 2009

Filed:

Apr 24, 2009

Appl. No.:

12/429644

Inventors:

Hao Chen - Columbia MD, US
Ming Liu - Rockville MD, US
Qi Su - Columbia MD, US
Manish Raisinghani - Jamesburg NJ, US

International Classification:

A61K 31/4245

US Classification:

514364

Abstract:

Derivatives of Sydnonimine and its analogues, which bind selectively to dopamine transporter (DAT) proteins are useful for treating and delaying the progression of disorders and illnesses that are alleviated by inhibiting dopamine reuptake.

US Patent:

20110020466, Jan 27, 2011

Filed:

Jan 9, 2009

Appl. No.:

12/812355

Inventors:

Jerald Bain - Toronto, CA
Hao Chen - Columbia MD, US
Joel Sadavoy - Toronto, CA
David Arthur Weissman - Baltimore MD, US

Assignee:

United Paragon Associates Inc. - Guelph

International Classification:

A61K 35/54
A61P 25/24
A61P 25/22

US Classification:

424581, 424582

Abstract:

Fertilized egg isolate, methods for preparing the fertilized egg isolate and uses thereof for treating mental health disorders and disease or conditions mediated by or associated with one or more glutamate receptors or by the neurokinin 2 (NK2) receptor.

US Patent:

20120190743, Jul 26, 2012

Filed:

Sep 7, 2010

Appl. No.:

13/394067

Inventors:

Jerald Bain - Toronto, CA
Joel Sadavoy - Toronto, CA
Hao Chen - Columbia MD, US
Xiaoyu Shen - Columbia MD, US

Assignee:

UNITED PARAGON ASSOCIATES INC. - Guelph ON

International Classification:

A61K 31/23
C07C 69/30
A61P 25/24
A61P 25/22
A61P 1/00
A61P 29/00
A61P 11/00
A61P 13/10
A61P 15/00
A61P 25/00
A61P 25/30
A61P 5/00
A61P 3/00
C12N 5/071
C07C 69/33

US Classification:

514552, 554227, 435375

Abstract:

Compounds, pharmaceutical compositions and methods of treating a disorder or disease associated with neurokinin 2 (NK) receptor activity.