Harriet Robinson

US Patent:

6841381, Jan 11, 2005

Filed:

Jan 27, 1994

Appl. No.:

08/187879

Inventors:

Harriet L. Robinson - Southboro MA, US
Ellen F. Fynan - Sterling MA, US
Robert G. Webster - Memphis TN, US
Shan Lu - Northboro MA, US

Assignee:

University of Massachusetts Medical Center - Worcester MA
St. Jude Children's Research Hospital - Memphis TN

International Classification:

C12N 1563
C12N 1500

US Classification:

4353201, 435 691, 435325, 435455

Abstract:

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune response can provide protection against infection by pathogenic agents, provide an anti-tumor response, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.

US Patent:

20060014714, Jan 19, 2006

Filed:

Jul 12, 2005

Appl. No.:

11/178588

Inventors:

Harriet Robinson - Southborough MA, US
Joel Haynes - Middleton WI, US

International Classification:

A61K 48/00
A61K 39/145

US Classification:

514044000, 424209100

Abstract:

An approach to genetic vaccine methodology is described. A genetic construction encoding antigenic determinants of a virus is transfected into cells of the vaccinated individuals using a particle acceleration protocol so as to express the viral antigens in healthy cells to produce an immune response to those antigens.

US Patent:

61659932, Dec 26, 2000

Filed:

Mar 2, 1998

Appl. No.:

9/233813

Inventors:

John E. Herrmann - Northborough MA
Harriet L. Robinson - Southborough MA
Ellen F. Fynan - Sterling MA

Assignee:

University of Massachusetts Medical Center - Worcester MA

International Classification:

A61K 317052
C12N 1563
C12N 1588

US Classification:

514 44

Abstract:

This invention relates to methods of eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate a DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e. g. , capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal viral antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.

US Patent:

56435789, Jul 1, 1997

Filed:

Jan 27, 1993

Appl. No.:

8/009833

Inventors:

Harriet L. Robinson - Southboro MA
Ellen F. Fynan - Sterling MA
Robert G. Webster - Memphis TN

Assignee:

University of Massachusetts Medical Center - Worcester MA
St. Jude Children's Research Hospital - Memphis TN

International Classification:

A61K 39145
A61K 3900
C07H 2104
C12N 1511

US Classification:

4242101

Abstract:

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune responses can provide protection against infection by pathogenic agents, provide an anti-tumor responses, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.

US Patent:

56208960, Apr 15, 1997

Filed:

Apr 20, 1995

Appl. No.:

8/426169

Inventors:

John E. Herrmann - Northborough MA
Harriet L. Robinson - Southborough MA
Ellen F. Fynan - Sterling MA

Assignee:

University of Massachusetts Medical Center - Worcester MA

International Classification:

C12N 1563
A61K 4800

US Classification:

4353201

Abstract:

This invention relates to methods of eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate a DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e. g. , capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal vital antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.