Harriet L Robinson

US Patent:

6841381, Jan 11, 2005

Filed:

Jan 27, 1994

Appl. No.:

08/187879

Inventors:

Harriet L. Robinson - Southboro MA, US
Ellen F. Fynan - Sterling MA, US
Robert G. Webster - Memphis TN, US
Shan Lu - Northboro MA, US

Assignee:

University of Massachusetts Medical Center - Worcester MA
St. Jude Children's Research Hospital - Memphis TN

International Classification:

C12N 1563
C12N 1500

US Classification:

4353201, 435 691, 435325, 435455

Abstract:

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune response can provide protection against infection by pathogenic agents, provide an anti-tumor response, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.

US Patent:

7795017, Sep 14, 2010

Filed:

Dec 9, 2004

Appl. No.:

11/009063

Inventors:

Harriet L. Robinson - Atlanta GA, US
Rama R. Amara - Atlanta GA, US
Ted M. Ross - Aspinall PA, US
Rick A. Bright - Atlanta GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

C07H 21/04
C12N 15/63

US Classification:

4353201, 536 231

Abstract:

The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector.

US Patent:

7850956, Dec 14, 2010

Filed:

Jan 22, 2004

Appl. No.:

10/763049

Inventors:

Harriet L. Robinson - Atlanta GA, US
Ellen F. Fynan - Sterling MA, US
Robert G. Webster - Memphis TN, US
Shan Lu - Franklin MA, US

Assignee:

University of Massachusetts Medical Center - Worcester MA
St. Jude Children's Research Hospital - Memphis TN

International Classification:

A61K 48/00
A61K 39/12

US Classification:

424 932, 514 44, 4241861

Abstract:

This invention relates to a method of immunizing a vertebrate, comprising introducing into the vertebrate a DNA transcription unit which comprises DNA encoding a desired antigen or antigens. The uptake of the DNA transcription unit by a host vertebrate results in the expression of the desired antigen or antigens, thereby eliciting humoral or cell-mediated immune responses or both humoral and cell-mediated responses. The elicited humoral and cell-mediated immune response can provide protection against infection by pathogenic agents, provide an anti-tumor response, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.

US Patent:

7867982, Jan 11, 2011

Filed:

Jan 22, 2008

Appl. No.:

12/018150

Inventors:

Bernard Moss - Bethesda MD, US
Linda Wyatt - Rockville MD, US
Patricia Earl - Chevy Chase MD, US
Harriet L. Robinson - Atlanta GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

A61K 35/12
A61P 43/00

US Classification:

514 44, 530350

Abstract:

The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.

US Patent:

8623379, Jan 7, 2014

Filed:

Jan 3, 2003

Appl. No.:

10/336566

Inventors:

Harriet L. Robinson - Atlanta GA, US
James Smith - Decatur GA, US
Jian Hua - Dunwoody GA, US

Assignee:

Emory University - Atlanta GA

International Classification:

C12Q 1/70
C12N 15/63
C12N 15/33
C12N 15/48
C12N 15/49
A61K 39/21

US Classification:

4241991, 4242041, 4242081, 4242321, 4353201

Abstract:

We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained from one clade or from two or more different clades, and the antigens selected and/or the manner in which the vectors are formulated (e. g. , mixed) can be manipulated to generate a protective immune response against a variety of clades (e. g. , the clades to which a patient is most likely to be exposed; with the proportions of the components of the vaccine tailored to the extent of the patient's risk to a particular clade or clades).

US Patent:

20020106798, Aug 8, 2002

Filed:

Mar 2, 2001

Appl. No.:

09/798675

Inventors:

Harriet Robinson - Atlanta GA, US
James Smith - Tucker GA, US
Ted Ross - Winterville NC, US
Rick Bright - Atlanta GA, US
Jian Hua - Decatur GA, US
Dennis Ellenberger - Norcross GA, US
Donald Hildebrand - Athens GA, US

International Classification:

C12N015/86
C12N007/00

US Classification:

435/456000, 435/320100, 435/235100

Abstract:

The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.

US Patent:

20040105871, Jun 3, 2004

Filed:

Mar 8, 2002

Appl. No.:

10/093953

Inventors:

Harriet Robinson - Atlanta GA, US
James Smith - Decatur GA, US
Jian Hua - Dunwoody GA, US

International Classification:

A61K039/12
C12N007/00
C12N015/863

US Classification:

424/199100, 435/235100, 435/456000

Abstract:

The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention, however, is particularly useful for inducing in a patient an immune response against pathogenic viruses such as HIV, measles or influenza. Immunodeficiency virus vaccine inserts of the present invention express non-infectious HIV virus-like particles (VLP) bearing multiple viral epitopes. VLPs allow presentation of the epitopes to multiple histocompatability types, thereby reducing the possibility of the targeted virus escaping the immune response. Also described are methods for immunizing a patient by delivery of a novel plasmid of the present invention to the patient for expression of the vaccine insert therein. Optionally, the immunization protocol may include a booster vaccination that may be a live vector vaccine such as a recombinant pox virus or modified vaccinia Arbora vector. The booster live vaccine vector includes a transcription cassette expressing the same vaccine insert as the primary immunizing vector.

US Patent:

20040146528, Jul 29, 2004

Filed:

Aug 22, 2003

Appl. No.:

10/646628

Inventors:

Bernard Moss - Bethesda MD, US
Linda Wyatt - Rockville MD, US
Patricia Earl - Chevy Chase MD, US
Harriet Robinson - Atlanta GA, US

International Classification:

A61K039/12
C12N007/00

US Classification:

424/199100, 435/235100

Abstract:

The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.