Ian M. Bell - Harleysville PA, US Mark E. Fraley - North Wales PA, US Steven N. Gallicchio - Horsham PA, US Anthony Ginnetti - Perkasie PA, US Helen J. Mitchell - Richboro PA, US Daniel V. Paone - West Point PA, US Donnette D. Staas - Holland PA, US Cheng Wang - Fort Washington PA, US Blair C. Zartman - Hatfield PA, US Heather E. Stevenson - Ardmore PA, US
International Classification:
C07D 471/04 C07D 487/04
US Classification:
5142651, 546 15, 514278, 544230
Abstract:
The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
John A. McCauley - Maple Glen PA, US Hemaka A. Rajapakse - Wyncote PA, US Thomas J. Greshock - Collegeville PA, US John Sanders - Philadelphia PA, US Boyoung Kim - Lansdale PA, US Vanessa L. Rada - Hatfield PA, US Jonathan T. Kern - Souderton PA, US Heather H. Stevenson - Ardmore PA, US Mark T. Bilodeau - Lansdale PA, US
International Classification:
C07D 495/04 C07D 495/10
US Classification:
5142338, 546114, 514301, 546 18, 514278, 544127
Abstract:
Disclosed are compounds of Formula (I): and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO—, —O— or NR—, wherein Rac is H, or Calkyl and Rthrough Rare defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.
John A. McCauley - Maple Glen PA, US Thomas J. Greshock - Collegeville PA, US John Sanders - Collegeville PA, US Heather H. Stevenson - Conshohocken PA, US Jonathan T. Kern - Souderton PA, US Ronald K. Chang - Oreland PA, US
Disclosed are compounds of Formula I: and the pharmaceutically acceptable salts thereof, wherein “A” is S—; —SO—, —SO—, —O— or NR, and R, and Rthrough Rare defined herein. Also disclosed are pharmaceutical formulations comprising a compound of Formula I and methods of treating, managing, or ameliorating diseases amenable to treatment, management, or amelioration by inhibition of LRRK2 kinase activity, for example, Parkinson's disease.
Ian M. Bell - Harleysville PA, US Mark E. Fraley - North Wales PA, US Steven N. Gallicchio - Horsham PA, US Anthony Ginnetti - Perkasie PA, US Helen J. Mitchell - Richboro PA, US Daniel V. Paone - Lansdale PA, US Donnette D. Staas - Holland PA, US Heather E. Stevenson - Philadelphia PA, US Cheng Wang - Fort Washington PA, US C. Blair Zartman - Hatfield PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/439 A61K 31/527 A61P 25/06 C07D 471/20
US Classification:
5142651, 546 15, 514278, 544230
Abstract:
The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
- Rahway NJ, US Mark E. Fraley - North Wales PA, US Steven N. Gallicchio - Horsham PA, US Anthony Ginnetti - Perkasie PA, US Helen J. Mitchell - Richboro PA, US Daniel V. Paone - Lansdale PA, US Donnette D. Staas - Harleysville PA, US Cheng Wang - Fort Washington PA, US C. Blair Zartman - Hatfield PA, US Heather E. Stevenson - Conshohocken PA, US
International Classification:
C07D 471/04
US Classification:
514278, 546 15
Abstract:
The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Teva Pharmaceuticals - Horsham, PA since Aug 2011
Regulatory Specialist
Merck - West Point, PA Jul 2007 - Aug 2011
Medicinal Chemist
Pfizer May 2005 - Aug 2005
Intern - Dept of Neuroscience
Pfizer May 2004 - Aug 2004
Intern - Dept of Global Manufacturing
Education:
Villanova University 2008 - 2010
M.S., Chemistry
The College of William and Mary 2003 - 2007
B.S., Chemistry
Career Manager At Lake Cumberland Area Development District
Aug 2011 to Present Regulatory Affairs AssociateMerck & Co., Inc West Point, PA Jul 2007 to Aug 2011 Chemist / Medicinal ChemistryPfizer Global Research and Development Groton, CT May 2005 to Aug 2005 Chemist / Dept of NeurosciencePfizer Global Research and Development Groton, CT May 2004 to Aug 2004 Chemist / Dept of Global Manufacturing
Education:
Villanova University Villanova, PA Mar 2011 Certificate in Project ManagementVillanova University Villanova, PA May 2010 Master of Science in ChemistryTemple University Philadelphia, PA 2010 Drug Development courseThe College of William and Mary Williamsburg, VA May 2007 Bachelor of Science in Chemistry
Skills:
Chemical synthesis and characterization (NMR, LCMS, TLC, HPLC) Microsoft Office (Outlook, Word, Excel, Powerpoint) Regulatory Submissions (eCTD, ANDA, hybrid) Electronic Document Management Systems (FirstDoc, KnowledgeTree, Master Control) Adobe Acrobat Scientific Databases (SciFinder, Bielstein) Chemical Drawing Programs
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