Heather A Webb

US Patent:

6646149, Nov 11, 2003

Filed:

May 31, 2000

Appl. No.:

09/584175

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA 98072
Christine L. ODay - Mountlake Terrace WA 98043
Heather K. Webb - Seattle WA 98107
Mark R. Burns - Shoreline WA 98177
Donald E. Bergstrom - West Lafayette IN 47906

International Classification:

C07C27112

US Classification:

560 25, 549 65, 549560, 564 83, 564 84, 564215, 514269, 514270, 514290, 514299, 514354, 514361, 514378, 514445, 514468, 514478, 514520, 514561, 514602, 514616, 514629, 514673, 514674, 544300, 546101, 546152, 548127, 548248, 548537, 558411

Abstract:

Novel âbispolyamineâ inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. These compounds display desirable activities both for diagnostic and research assays and therapy.

US Patent:

7160923, Jan 9, 2007

Filed:

Nov 14, 2000

Appl. No.:

09/713512

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA, US
Christine L. O'Day - Mountlake Terrace WA, US
Heather K. Webb - Seattle WA, US
Mark R. Burns - Shoreline WA, US
Donald E. Bergstrom - West Lafayette IN, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA

International Classification:

A61K 31/27
A61K 31/18
A61K 31/165
A61K 31/17
A61K 31/34

US Classification:

514626, 514311, 514365, 514378, 514423, 514445, 514471, 514481, 514596, 514602, 514603, 514616, 514617, 514625, 544144, 548200, 548243, 5483251, 548536, 549479, 560157, 564 48, 564 80, 564 83, 564 84, 564 86, 564161, 564180, 564197

Abstract:

Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinatiorial polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

US Patent:

7208528, Apr 24, 2007

Filed:

Sep 15, 1999

Appl. No.:

09/396523

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA, US
Christine L. O'Day - Mountlake Terrace WA, US
Heather K. Webb - Seattle WA, US
Mark R. Burns - Shoreline WA, US
Donald E. Bergstrom - West Lafayette IN, US

Assignee:

MediQuest Therapeutics, Inc. - Bothell WA

International Classification:

A61K 31/47
A61K 31/425
A61K 31/42
A61K 31/17
A61K 31/16

US Classification:

514626, 514311, 514365, 514378, 514423, 514445, 514471, 514481, 514596, 514602, 514603, 514616, 514617, 514625, 544144, 548200, 548248, 5483751, 548536, 549479, 560157, 564197, 564 48, 564 80, 564 83, 564 84, 564 86, 564161, 564180

Abstract:

Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinational polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.

US Patent:

61722618, Jan 9, 2001

Filed:

Sep 3, 1999

Appl. No.:

9/341400

Inventors:

Nicolaas M. J. Vermeulin - Woodinville WA
Christine L. O'Day - Mountlake Terrace WA
Heather K. Webb - Seattle WA
Mark R. Burns - Shoreline WA
Donald E. Bergstrom - West Lafayette IN

Assignee:

Oridigm Corporation - Seattle WA

International Classification:

C07C30300

US Classification:

564 84

Abstract:

Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. Novel chemical synthetic methods to obtain polyamine analogues are disclosed, including the production of a combinational polyamine library. These approaches yield analogues with desirable activities both for diagnostic and research assays and therapy. The assays of the invention are useful for high throughput screening of targets in the discovery of drugs that interact with the polyamine system.