Heather Webb

US Patent:

20020156023, Oct 24, 2002

Filed:

Dec 5, 2001

Appl. No.:

10/010740

Inventors:

Jacqueline Walling - Bristol, GB
Heather Webb - San Francisco CA, US
Alan Calvert - Newcastle, GB
David Newell - Northumbria, GB

Assignee:

Tularik Inc. - South San Francisco CA

International Classification:

A61K031/7048
A61K031/704
A61K038/21
A61K031/66
A61K031/525
A61K031/517

US Classification:

514/027000, 424/085500, 514/034000, 514/266400, 514/110000, 514/414000, 514/251000, 514/449000, 424/649000, 514/492000, 514/521000

Abstract:

The present invention provides compositions and methods for treating proliferative disorders using combination therapies of lometrexol and other therapeutically active agents. The methods include administration of lometrexol with one or more therapeutically active agents where lometrexol and the therapeutically active agent(s) are delivered in a single composition, where they are administered in separate compositions in a simultaneous manner, where lometrexol is administered first, followed by the therapeutically active agent(s), as well as where the therapeutically active agent(s) is delivered first, followed by lometrexol. In preferred embodiments, the therapeutically active agent(s) has antiproliferative properties.

US Patent:

20080200467, Aug 21, 2008

Filed:

Nov 2, 2007

Appl. No.:

11/934698

Inventors:

Dinesh Patel - Fremont CA, US
Richard D. Gless - Oakland CA, US
Heather K. Webb Hsu - San Francisco CA, US
Sampath Kumar Anandan - Fremont CA, US
Bhaskar R. Aavula - Pleasanton CA, US

International Classification:

A61K 31/5375
C07C 237/00
A61K 31/164
C07D 233/54
A61P 9/00
A61P 3/10
A61P 11/00
A61K 31/4164
A61K 31/445
C07D 295/00

US Classification:

5142378, 564169, 514621, 544162, 564188, 514623, 546233, 514331, 5483381, 514399

Abstract:

Disclosed are alpha keto amide and alpha hydroxy amide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases.

US Patent:

20080221104, Sep 11, 2008

Filed:

Nov 2, 2007

Appl. No.:

11/934642

Inventors:

Heather Kay Webb Hsu - San Francisco CA, US

International Classification:

A61K 31/4468
A61K 31/5375
A61P 29/00

US Classification:

5142375, 514329

Abstract:

Methods for reducing autoimmune induced inflammation, including rheumatoid arthritis in a subject in need of such therapy are disclosed.

US Patent:

20080221105, Sep 11, 2008

Filed:

Jan 28, 2008

Appl. No.:

12/021247

Inventors:

Heather Kay Webb Hsu - San Francisco CA, US

International Classification:

A61K 31/4468
A61P 3/00
A61K 31/5375

US Classification:

5142375, 514329

Abstract:

Compounds, compositions, and methods for inhibiting the onset of metabolic syndrome and treating related disorders in a subject in need of such therapy are disclosed.

US Patent:

20090247521, Oct 1, 2009

Filed:

Dec 23, 2008

Appl. No.:

12/343358

Inventors:

Bhasker R. Aavula - Pleasanton CA, US
Dinesh Patel - Fremont CA, US
Gabor Rubanyi - San Diego CA, US
Yi-Xin Wang - Lafayette CA, US
Heather K. Webb Hsu - Seattle WA, US

International Classification:

A61K 31/445
A61K 31/17
A61K 31/215
A61K 31/19
A61K 31/5377
A61K 31/4545
A61K 31/454
A61K 31/4709
A61P 9/00

US Classification:

5142355, 514588, 514511, 514557, 514329, 514318, 514326, 514314

Abstract:

The present invention generally relates to methods useful for a therapy using a class of urea or amide compounds and related compositions, wherein the compound is a soluble epoxide hydrolase inhibitor, for treating and ameliorating the symptoms of diseases related to endothelial dysfunction.

US Patent:

20130143902, Jun 6, 2013

Filed:

Nov 30, 2012

Appl. No.:

13/691524

Inventors:

Gilead Calistoga LLC - Foster City CA, US
Heather Webb - Seattle WA, US
Brian Lannutti - Seattle WA, US

Assignee:

GILEAD CALISTOGA LLC - Foster City CA

International Classification:

C07D 473/34
A61K 45/00
A61K 31/522

US Classification:

51426321, 544277

Abstract:

Provided are methods that relate to a novel therapeutic strategy for the treatment of cancers. In particular, the method comprises administration of Compound A,or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such compound admixed with at least one pharmaceutically acceptable excipient.