Hector E Gonzalez

US Patent:

6403835, Jun 11, 2002

Filed:

Nov 2, 2000

Appl. No.:

09/705060

Inventors:

Mark E. Davis - Pasadena CA
Patricia Andy - Mandelieu, FR
Javier Garcia Martinez - Alicante, ES
Gary Lee - Albany CA
Hector Gonzalez - San Francisco CA
Christopher W. Jones - Smyrna GA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C07C 4529

US Classification:

568309, 568338, 568 38, 568 44, 544128, 544135, 544146

Abstract:

The invention relates to the shape selective acylation of an organic compound. In particular, the invention describes a process for such acylation wherein the process comprises reducing the number of surface acid sites without dealuminations on at least a portion of the surface of a zeolite and acylating the organic compound in the presence of the zeolite. The organic compounds used in the invention include, for example, olefins, aromatic hydrocarbons, aromatic heterocyclic compounds, and phenolic compounds wherein the organic group may be substituted or unsubstituted. The zeolite may be any natural or synthetic zeolite with a unidimensional or multidimensional network, for example a two-dimensional, or three-dimensional network, or any molecular sieve with structural features similar to these.

US Patent:

6509323, Jan 21, 2003

Filed:

Dec 2, 1998

Appl. No.:

09/203556

Inventors:

Mark E. Davis - Pasadena CA
Hector Gonzalez - San Francisco CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K 3170

US Classification:

514 58, 536103, 536105, 536106, 536124

Abstract:

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

US Patent:

6884789, Apr 26, 2005

Filed:

Mar 15, 2002

Appl. No.:

10/097326

Inventors:

Mark E. Davis - Pasadena CA, US
Hector Gonzalez - San Francisco CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K031/715
C08B037/16
C08B031/18

US Classification:

514 58, 536103, 536105, 536106, 536124

Abstract:

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

US Patent:

7018609, Mar 28, 2006

Filed:

Dec 19, 2001

Appl. No.:

10/021312

Inventors:

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie Bellocq - Altadena CA, US
Jianjun Cheng - San Gabriel CA, US

Assignee:

California Institute of Technology - Pasadena CA
Insert Therapeutics, Inc. - Pasadena CA

International Classification:

A61K 51/00

US Classification:

424 161, 424 169

Abstract:

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

US Patent:

7091192, Aug 15, 2006

Filed:

Jun 25, 1999

Appl. No.:

09/339818

Inventors:

Mark E. Davis - Pasadena CA, US
Hector Gonzalez - San Francisco CA, US
Suzie Sue Jean Hwang - Torrance CA, US

Assignee:

California Institute of Technology - Pasedena CA

International Classification:

A61K 31/715
C08B 37/16
C08B 31/00
C07H 1/00
C07H 3/00

US Classification:

514 58, 536103, 536105, 536106, 536124

Abstract:

Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

US Patent:

7166302, Jan 23, 2007

Filed:

Dec 19, 2001

Appl. No.:

10/021294

Inventors:

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie Bellocq - Altadena CA, US
Jianjun Cheng - San Gabriel CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K 9/14
A61K 31/74
C12P 19/30
C12N 15/63

US Classification:

424486, 4242801, 424489, 424467, 424499, 435 6, 435 691, 435 72, 435455, 435458, 514 44, 514 54

Abstract:

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.

US Patent:

7375096, May 20, 2008

Filed:

Dec 3, 1999

Appl. No.:

09/453707

Inventors:

Mark E. Davis - Pasadena CA, US
Hector Gonzalez - San Francisco CA, US

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K 31/724
A61K 8/11
C12N 15/63

US Classification:

514 58, 424486, 424488, 435455, 527300

Abstract:

A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a therapeutically effective amount of a supramolecular complex of the invention is also described. Such a supramolecular complex may be used as a delivery vehicle for various therapeutic agents.

US Patent:

7807198, Oct 5, 2010

Filed:

Dec 28, 2005

Appl. No.:

11/321441

Inventors:

Suzie Hwang Pun - Torrance CA, US
Hector Gonzalez - San Francisco CA, US
Mark E. Davis - Pasadena CA, US
Nathalie C. Bellocq - Altadena CA, US
Jianjun Cheng - Arcadia CA, US

Assignee:

California Institute of Technology - Pasadena CA
Calando Pharmaceuticals, Inc. - Pasadena CA

International Classification:

A61K 9/14
A61K 31/74

US Classification:

424486, 4242801, 424489, 424467, 424499

Abstract:

The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.