Henry W Querfurth

US Patent:

20040230124, Nov 18, 2004

Filed:

May 12, 2003

Appl. No.:

10/436548

Inventors:

Henry Querfurth - Wellesley MA, US

International Classification:

A61B005/02

US Classification:

600/485000

Abstract:

A non-invasive method and system for assessing intraocular pressure (ICP) is disclosed. The method comprises the steps of measuring venous outflow pressure (VOP) using a venous ophthalmodynamometer device (vODM); measuring ophthalmic r central retinal arterial blood flow using color Doppler imaging device; and then estimating ICP using venous outflow data from the vODM and pulsatility and/or resistivity relationships derived from the Doppler imaging data. Further disclosed is a novel vODM for measuring VOP in low flow veins.

US Patent:

20110165598, Jul 7, 2011

Filed:

Jun 10, 2009

Appl. No.:

12/997154

Inventors:

Henry W. Querfurth - Wellesley MA, US

International Classification:

G01N 33/53

US Classification:

435 792, 435 71

Abstract:

Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by Aβ oligomers.

US Patent:

20220347136, Nov 3, 2022

Filed:

Apr 8, 2022

Appl. No.:

17/716156

Inventors:

- Waltham MA, US
Henry W. Querfurth - Wellesley MA, US

International Classification:

A61K 31/192
A61K 31/405
A61P 25/28

Abstract:

Provided are compositions and methods useful for sensitizing a neuron to insulin or insulin-like growth factor 1 (IGF-1), wherein the neuron is resistant to either insulin or IGF-1. Also provided are compositions and method useful for inhibiting intracellular beta amyloid peptide Aβ42-mediated decrease in neuronal viability. Also provided are compositions and methods useful for improving synaptic plasticity. Also provided are compositions and methods useful for improving learning and memory. In certain embodiments, the composition comprises (Z)-5-(4-chlorophenyl)-3-phenylpent-2-enoic acid (PS48). In certain embodiments, the method comprises contacting a neuron with PS48. In certain embodiments, the method comprises administering an effective amount of PS48 to a subject in need thereof.

US Patent:

20150247857, Sep 3, 2015

Filed:

Jan 30, 2015

Appl. No.:

14/609845

Inventors:

- Waltham MA, US
HENRY W. QUERFURTH - Wellesley MA, US

Assignee:

Eleanore Bennett Charitable Trust #2 - Waltham MA

International Classification:

G01N 33/573

Abstract:

Aspects of the invention relate to methods and compositions for treating Alzheimer's disease (AD). In some embodiments, the invention provides methods for screening and identifying compounds that selectively inhibit the targeting of the insulin-Akt signaling pathway by Aβ oligomers.