Henry R Wolfe

US Patent:

6548048, Apr 15, 2003

Filed:

Oct 25, 2000

Appl. No.:

09/695273

Inventors:

Alan Cuthbertson - Oslo, NO
Magne Solbakken - Oslo, NO
Henry Raphael Wolfe - Glenmoore PA

Assignee:

Amersham Health AS - Oslo

International Classification:

A61B 800

US Classification:

424 952, 424 951, 424450, 424489, 424499

Abstract:

Novel membrane-forming amphiphilic lipopeptides comprising one or more peptide moieties containing 2-50 aminoacyl residues and one or more hydrocarbon chains containing 5-50 carbon atoms. Such lipopeptides may be used in the formation of stabilized gas microbubble dispersions suitable for use as diagnostic and/or therapeutic agents, for example as ultrasound contrast agents.

US Patent:

8206704, Jun 26, 2012

Filed:

Feb 10, 2004

Appl. No.:

10/775481

Inventors:

Scott A. Waldman - Ardmore PA, US
Giovanni Mario Pitari - Philadelphia PA, US
Jason Park - Philadelphia PA, US
Stephanie Schulz - West Chester PA, US
Henry R. Wolfe - Glenmoore PA, US
Wilhelm Lubbe - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 38/00
A61K 39/395
A61K 39/00
A61P 43/00
A61P 35/00
A61P 35/04

US Classification:

4241301, 4241381, 4241421, 4241431, 4241781, 4241811, 514 11, 514 189, 514 192, 514 198

Abstract:

Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.

US Patent:

20020076378, Jun 20, 2002

Filed:

Jan 29, 2002

Appl. No.:

10/057943

Inventors:

Henry Wolfe - Wayne PA, US
Kenneth Kellar - Wayne PA, US

Assignee:

NYCOMED IMAGING AS

International Classification:

A61K049/04

US Classification:

424/009400

Abstract:

The invention provides compounds comprising a linear, branched or dendrimeric polymer backbone with linked thereto at least one reporter moiety, said polymer backbone comprising a plurality of amine-containing acids. Such compounds may be linked to one or more targeting agents and are useful as therapeutic and diagnostic agents, in particular in medical imaging techniques.

US Patent:

20080058300, Mar 6, 2008

Filed:

Apr 23, 2007

Appl. No.:

11/790083

Inventors:

Michael McLane - Plymouth Meeting PA, US
Kristen Lantz - Plymouth Meeting PA, US
Susan Emeigh Hart - Plymouth Meeting PA, US
Andrew Albright - Plymouth Meeting PA, US
Hsiao-Ling Hung - Plymouth Meeting PA, US
Henry Wolfe - Plymouth Meeting PA, US

International Classification:

A61K 31/575
A61P 3/00

US Classification:

514182000

Abstract:

The present invention is directed to the use of compound 1436 for the induction of weight loss in an obese mammal.

US Patent:

20100324004, Dec 23, 2010

Filed:

Sep 8, 2008

Appl. No.:

12/676701

Inventors:

Michael McLane - Southampton PA, US
Inez Ruiz-White - Southampton PA, US
Henry Wolfe - Glenmoore PA, US

International Classification:

A61K 31/585
A61K 31/58
A61K 31/56
C07J 43/00
C07J 17/00
C07J 41/00
A61P 3/10

US Classification:

514175, 514176, 514182, 540107, 540115, 552521

Abstract:

This application is directed to the use of steroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.

US Patent:

20120308583, Dec 6, 2012

Filed:

Jun 19, 2012

Appl. No.:

13/526771

Inventors:

Scott A. Waldman - Ardmore PA, US
Giovanni Mario Pitari - Philadelphia PA, US
Jason Park - Philadelphia PA, US
Stephanie Schulz - West Chester PA, US
Henry Wolfe - Glenmoore PA, US
Wilhelm Lubbe - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 38/02
A61P 35/00
A61K 39/395

US Classification:

4241781, 514 193

Abstract:

Proliferation of colorectal, gastric and esophageal cancer cells is inhibited by administering ST receptor ligand. The number of ST receptor molecules on the surface of a colorectal cell or metastasized colorectal cancer cell are increased by administering an ST receptor ligand such that ligand comes into contact with an ST receptor on the surface of the colorectal cell. Pharmaceutical compositions comprise sterile, pyrogen free ST receptor ligand and a pharmaceutically acceptable carrier or diluent. Metastasized colorectal cancer is treated or imaged by increasing the number of ST receptor molecules on the surface of a metastasized colorectal cancer cell and then administering a pharmaceutical composition containing components that target the ST receptor for delivery of a therapeutic agent or imaging agent. Methods of detecting metastasized colorectal cancer are disclosed. Methods of delivering active compounds to a colorectal cell in an individual are disclosed.

US Patent:

20140038881, Feb 6, 2014

Filed:

Jun 8, 2011

Appl. No.:

13/984523

Inventors:

Henry Wolfe - Glenmoore PA, US
Reinhard Ebner - Gaithersburg MD, US

Assignee:

COMBIMAB, INC - Chevy Chase MD

International Classification:

C07K 4/00
A61K 45/06
A61K 38/03

US Classification:

514 17, 530300, 514 215, 514 214, 514 183, 514 193, 514 18

Abstract:

Therapeutic peptides having guanylyl cyclase C agonist activity are disclosed. The therapeutic peptides are analogues of the STa peptide with non-natural amino acid, isosteric or D-amino acid substituents. The therapeutic peptides are useful in the treatment of chronic ideopathic constipation, inflammatory bowel disease, and other diseases. Pharmaceutical compositions comprising comprising the therapeutic peptides are also disclosed.

US Patent:

47756292, Oct 4, 1988

Filed:

May 5, 1987

Appl. No.:

7/045628

Inventors:

Ernest B. Kuhl - Pennsville NJ
George R. Long - Newark DE
Juleen A. Mitchell - Wilmington DE
Richard S. Jenkins - Kennett Square PA
Henry R. Wolfe - Newark DE
Gerard F. Malone - Marlton NJ

Assignee:

E. I. Du Pont de Nemours and Company - Wilmington DE

International Classification:

C12M 116

US Classification:

435299

Abstract:

A cartridge is formed of two parts which form an outlet valve at the lower end. The valve is opened or closed by relative rotation of the parts.