Herbert W Evans

US Patent:

59488875, Sep 7, 1999

Filed:

Sep 19, 1997

Appl. No.:

8/933402

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07K 706
C07K 308
A61K 3702
A61K 3804

US Classification:

530333

Abstract:

Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.

US Patent:

61471895, Nov 14, 2000

Filed:

Sep 19, 1997

Appl. No.:

8/934223

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07K 706
C07K 308
A61K 3702
A61K 3804

US Classification:

530333

Abstract:

Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.

US Patent:

60840668, Jul 4, 2000

Filed:

Jan 15, 1999

Appl. No.:

9/231797

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, IN

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07K 706
C07K 308
A61K 3702
A61K 3804

US Classification:

530333

Abstract:

Homologs and analogs of naturally-occurring stem cell factor polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.

US Patent:

61000442, Aug 8, 2000

Filed:

Sep 19, 1997

Appl. No.:

8/934224

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Redmond VA

International Classification:

G01N 3353
G01N 33566
A61K 3800

US Classification:

435 71

Abstract:

Homologs and analogs of naturally occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are identified by the presence of flanking conformation-constraining moieties, such as proline or cysteine.

US Patent:

61110698, Aug 29, 2000

Filed:

Sep 19, 1997

Appl. No.:

8/933843

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07K 706
C07K 308
A61K 3702
A61K 3804

US Classification:

530333

Abstract:

Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.

US Patent:

59524650, Sep 14, 1999

Filed:

Dec 9, 1998

Appl. No.:

9/207621

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C07K 706
C07K 308
A61K 3702
A61K 3804

US Classification:

530333

Abstract:

The present invention relates to method of producing a conformationally-constrained polypeptide that mimics the activity of an immunomodulator peptide, wherein the method comprises: producing the conformationally-constrained polypeptide, wherein the conformationally-constrained polypeptide contains a protein--protein interaction site of said immunomodulator peptide adjacently flanked on both termini by proline residues in a manner distinct from the manner found in the naturally occurring immunomodulator peptide.

US Patent:

59656980, Oct 12, 1999

Filed:

May 3, 1996

Appl. No.:

8/532818

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3804
A61K 3810
A61K 3816
A61K 3836

US Classification:

530326

Abstract:

Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.

US Patent:

59288965, Jul 27, 1999

Filed:

Sep 19, 1997

Appl. No.:

8/934222

Inventors:

Herbert J. Evans - Richmond VA
R. Manjunatha Kini - Singapore, SG

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

C12P 2106
C12P 1934
A61K 3804

US Classification:

435 691

Abstract:

Homologs and analogs of naturally-occurring polypeptides contain one or more interaction sites of the natural counterpart. The interaction sites are flanked by conformation-constraining moieties, such as proline or cysteine.